FGE 3de Bach Les 4 Translationeel onderzoek 052023.pdf

Methodologie van het klinisch wetenschappelijk
onderzoek

Les 4: Translationeel onderzoek




Prof. Dr. Guy Brusselle




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,Methodologie van klinisch wetenschappelijk onderzoek
1) Les 1: Real life effectiveness / patient-centered
research
2) Les 2: Interventionele studies (RCTs)
3) Les 3: Benefit risk ratio / farmacogenetica

4) Les 4: Translationeel onderzoek
5) Les 5: Ethiek; wetenschappelijke integriteit
6) Les 6: Practicum; COVID-19.




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, Translational research




Oregon Clinical and Translational Science Institute (OCTRI)
Translating Research Into Practice and Policy (TRIPP)
Mularski RA, The Center for Health Research, Northwest Kaiser Permanente.

Bench = labo
Bedside = zieke pt


Clinical trials zijn fase 1,2,3 studies




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, Translational research: 3 translations

1. Translation to Patients (T1):
 From bench to bedside (Bidirectional)
2. Translation to Populations (T2):
 From individual patients to efficacy RCTs and/
or large population-based cohorts (Bidirectional)
3. Translation to Practice (T3):
 From efficacy RCTs to clinical practice
Guidelines (effectiveness and implementation)




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