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NMTCB PET EXAM STUDY GUIDE– NUCLEAR MEDICINE TECHNOLOGY CERTIFICATION BOARD - REAL EXAM QUESTIONS & VERIFIED ANSWERS – PASS FIRST ATTEMPT GUARANTEED – NEWEST UPDATE 2026

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NMTCB PET EXAM STUDY GUIDE – Comprehensive preparation resource for the Nuclear Medicine Technology Certification Board (NMTCB) exam, featuring a collection of real exam questions with verified answers. This study guide is designed to help you confidently pass the exam on your first attempt and includes the newest updates, ensuring you have the most current and relevant information available, prepared for the 2026 exam cycle.

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NMTCB
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NMTCB

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Malignant Pulmonary Nodules on CT are characterized by: - ANSWER Mixed Attentuation



Hodkin's Lymphoma is separated from other Lymphomas by the presence of: - ANSWER
Reed-Sternberg Cells



Two types of Alzheimer's mediciation: - ANSWER Acetylecholinestrearse Inhibitors

N-methyl-D-aspartate receptor antagonists



Lymphatic Drainage for most of the body is via: - ANSWER Left Subclavian Vein



Hormone made in kidney's that signals the bone marrow to make more RBCs: - ANSWER
Erythropoietin



Affects woman >65

Renal Cell carcinomas mostly

Wilm's Tumor (pediatric)

covered under guidlines - ANSWER Renal Cancer



Most begins in ducts

Spreads to peritoneum, liver, lungs

Imaging neck to pelvis

Covered under CMS NCD - ANSWER Pancreatic Cancer



The Liver primarily receives blood from: - ANSWER Portal Vein and Hepatic Artery

1

,Men >65

Cardia, fundus, corpus, antrum, pylorus

Imaging Neck to Lower Pelvis

Five layers; mucosa, submucosa, muscularis, subserosa, serosa - ANSWER Gastric Cancer



Pacemaker of GI Tract - ANSWER Cells of Cajal



Breast Cancer CMS coverage - ANSWER Staging, Restaging, Monitoring response to
theraphy



Lung Cancer CMS coverage - ANSWER Initial or Subsequent treatment strategy



Two major types of Lung Cancer: - ANSWER Non-Small Cell

-More Common

-Spreads slowly

-Bone, Liver, Brain, Adrenal Glands

Small Cell

-Rapid Growth



Affects men more than women

>65 years

Squamous cell and mucinoid

Neck to pelvis imaging - ANSWER Esophageal Cancer



Initial Treatment, restaging, response to therapy, recurrance - ANSWER Esophageal Can-
cer coverage



2

,Brain structure described as "sensory relay" - ANSWER Thalamus



Physiochemical property of a PET tracer that decides it's ability to enter the brain and label
the target receptor or enzyme: - ANSWER Lipophilicity



Binds to mitochondrial complex 1

Used for myocardial perfusion imaging

Nucleophillic Substitution and Purification

Performed similar to Tc-99m Rest/Stress - ANSWER F-18 Flurpiridaz



Beta particles are electrons that contain _____________ and ____________. - ANSWER
Negatrons and Positrons



Proton rich nuclei decay either by _____________ or ______________ . - ANSWER Elec-
tron Capture or Positron decay



Mean energy of an ejected positron is about ___________ of the max energy. - ANSWER
1/3



ex: F-18 Max = 635 KeV Mean = 210 KeV



Longer range of travel for a positron before annihilation will ___________ resolution. - AN-
SWER Decrease Resolution



Annihilation Reaction - ANSWER Positron emitted from atom w/ high kin. energy

Slows, combines w/ electron

Forms postironium briefly, spin

Mass is converted to energy, release two 511 KeV photons



3

, Non-colinearity results in blurring effect on clinical PET scanners of approximately _____ mm
and angle of _____ deviation from 180. - ANSWER 2 mm

0.25 degree deviation



Ionization chamber is a ____________ detector w/ a ______________ and ______________
. - ANSWER Gas-Filled

Anode and Cathode

Operates at Low Voltage



Ionization chamber is calibrated annually using a _____________

source so that exposure rate a given distance is known. - ANSWER National Institute of
Standards and Technology ( NIST)



Gas-Filled (noble gases)

High Voltage

Secondary Ionization ---> Townsend Avalanche = high sensitivity - ANSWER Geiger-Muller



A 2D projection space representation of a transaxial image - ANSWER Sinogram



Represents shift on LOR from the center of the gantry - ANSWER X-axis sinogram



Represents projection angle of LOR - ANSWER Y-axis sinogram



CT artifact caused by a faulty detector

Produces ring or concentric circles on CT image - ANSWER Ring Artifact



Electrons are emitted from matter




4

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