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WGU D118 Exam Practice 2 (2026) – 250+ Q&A | Primary Care, Pharmacology, HTN, Diabetes & Diagnostics

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This document provides a comprehensive and high-yield collection of over 250 exam-style questions with verified answers for WGU D118 Exam Practice 2, focusing on primary care medicine and clinical decision-making. It covers essential topics such as hypertension management (first-line therapies like thiazides and ACE inhibitors), diabetes care (metformin use and contraindications), and acute/emergency conditions (stroke, pulmonary embolism, septic arthritis). As shown on page 1 of , the material is structured in a clear Q&A format, combining concise explanations with clinically relevant reasoning for effective exam preparation. The content is aligned with major clinical references such as Bates’ Guide to Physical Examination and History Taking, Current Medical Diagnosis & Treatment, and standard primary care and pharmacology guidelines (ADA, ACC/AHA). It provides in-depth coverage of diagnostic strategies (D-dimer → CT for PE, ferritin for iron deficiency anemia, TSH for thyroid disorders), first-line treatments (NSAIDs for gout, SSRIs for depression, PPIs for GERD), and red flag symptoms requiring urgent intervention (e.g., peak flow 50% in asthma, rebound tenderness in abdominal pain, neurologic deficits in headache). High-yield sections also include chronic disease management (COPD, CKD, heart failure), preventive care (cancer screening, osteoporosis DEXA), and medication safety (ACE inhibitor monitoring, DOAC contraindications). This document is ideal for: Students enrolled in WGU D118 or primary care/clinical courses Nurse practitioner (FNP) and medical students NCLEX-RN, USMLE, and board exam candidates Healthcare students focusing on diagnostics and pharmacology Clinicians reviewing evidence-based guidelines and red flag recognition It serves as a complete study guide, rapid review resource, and high-yield Q&A bank. The structured format enhances clinical reasoning, reinforces guideline-based care, and prepares learners for both exams and real-world patient management. Keywords: primary care medicine, hypertension treatment ACE inhibitor thiazide, diabetes metformin A1c, pulmonary embolism D dimer CT angiography, stroke management tPA CT head, COPD spirometry FEV1 FVC, asthma inhaled corticosteroids, gout NSAIDs urate crystals, iron deficiency anemia ferritin, GERD PPI treatment, depression SSRI PHQ9, DVT ultrasound DOAC, heart failure BNP echocardiogram, CKD eGFR ACE inhibitor, osteoporosis DEXA bisphosphonates

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WGU D118 High Yield EXAM
PRACTICE 2 2026 Expert
Verified | Ace the Test



First-line medication for uncomplicated hypertension - 🧠 ANSWER

✔✔Thiazide diuretic or ACE inhibitor - Thiazides and ACE-Is are first-line;

ACE-I preferred in diabetes for renal protection

Next step for ACE inhibitor-induced angioedema - 🧠 ANSWER

✔✔Discontinue ACE inhibitor immediately - Angioedema is life-threatening

and ACE-Is are permanently contraindicated

,Labs to check before starting an ACE inhibitor - 🧠 ANSWER ✔✔Serum

creatinine and potassium - Risk of renal dysfunction and hyperkalemia


Low back pain red flag requiring imaging - 🧠 ANSWER ✔✔New urinary

retention - Suggests cauda equina syndrome


Next step for acute monoarticular arthritis with fever - 🧠 ANSWER ✔✔Joint

aspiration - Must rule out septic arthritis before treating gout


First-line treatment for acute gout flare - 🧠 ANSWER ✔✔NSAIDs - First-line

unless contraindicated


Diagnostic confirmation of gout - 🧠 ANSWER ✔✔Monosodium urate

crystals on synovial fluid - Serum uric acid is not diagnostic


Initial test for suspected PE in low-risk patient - 🧠 ANSWER ✔✔D-dimer -

Negative result rules out PE


Next step after positive D-dimer - 🧠 ANSWER ✔✔CT pulmonary

angiography - Required to confirm PE


First-line treatment for mild persistent asthma - 🧠 ANSWER ✔✔Low-dose

inhaled corticosteroid - Cornerstone therapy

, Asthma hospitalization red flag - 🧠 ANSWER ✔✔Peak flow <50% predicted

- Indicates severe exacerbation


Preferred colon cancer screening at age 45 - 🧠 ANSWER ✔✔Colonoscopy

- Gold standard and diagnostic


COPD patient with frequent exacerbations next step - 🧠 ANSWER ✔✔Add

inhaled corticosteroid - Reduces exacerbation frequency


Diagnostic test confirming COPD - 🧠 ANSWER ✔✔Spirometry showing

FEV1/FVC <0.70 - Confirms airflow obstruction


First-line medication for type 2 diabetes - 🧠 ANSWER ✔✔Metformin -

Improves insulin sensitivity with CV benefit


Metformin contraindication - 🧠 ANSWER ✔✔eGFR <30 - Risk of lactic

acidosis


Lab monitoring long-term glucose control - 🧠 ANSWER ✔✔Hemoglobin A1c

- Reflects 3-month average


First-line hypothyroidism treatment - 🧠 ANSWER ✔✔Levothyroxine -

Synthetic T4 replacement




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