Latest Assessment -Solved
1. Which lipid fraction is most strongly associated with atherosclerotic cardiovascular
disease (ASCVD)?
A. HDL
• B. LDL
C. Triglycerides
D. VLDL
Rationale: Elevated LDL cholesterol is the primary driver of plaque formation and
ASCVD risk.
2. First-line pharmacologic therapy for hyperlipidemia in CAD prevention?
A. Niacin
• B. Statins
C. Fibrates
D. Fish oil
Rationale: Statins reduce LDL and ASCVD events; cornerstone of therapy.
3. Which lifestyle modification most effectively lowers LDL?
A. Increased physical activity
• B. Reduced saturated fat intake
C. Omega-3 supplementation
D. Smoking cessation
Rationale: Diet low in saturated/trans fats directly lowers LDL.
4. Which lipid abnormality is most common in metabolic syndrome?
A. High HDL
B. Low LDL
• C. Elevated triglycerides
D. Low total cholesterol
Rationale: Metabolic syndrome often presents with high TG and low HDL.
5. Which statin is considered high-intensity?
A. Pravastatin 40 mg
B. Simvastatin 20 mg
• C. Atorvastatin 80 mg
D. Lovastatin 40 mg
Rationale: High-intensity statins lower LDL ≥50%.
6. Which patient group benefits most from statin therapy?
A. Adults with LDL <70 mg/dL
, • B. Adults with clinical ASCVD
C. Children under 12
D. Adults with HDL >60 mg/dL
Rationale: Secondary prevention in ASCVD patients is strongest indication.
7. Which lab should be monitored with statin therapy?
A. CBC
• B. Liver function tests (LFTs)
C. Thyroid panel
D. Vitamin D
Rationale: Statins may cause hepatotoxicity; baseline and follow-up LFTs required.
8. Which lipid-lowering drug is contraindicated in pregnancy?
A. Omega-3 fatty acids
B. Bile acid sequestrants
• C. Statins
D. Niacin
Rationale: Statins are teratogenic; contraindicated in pregnancy.
9. Which lipid abnormality is most strongly linked to pancreatitis?
A. High LDL
B. Low HDL
• C. Triglycerides >500 mg/dL
D. Elevated total cholesterol
Rationale: Severe hypertriglyceridemia increases pancreatitis risk.
10. Which non-statin agent lowers LDL by inhibiting cholesterol absorption?
A. Fibrate
B. Niacin
• C. Ezetimibe
D. Fish oil
Rationale: Ezetimibe blocks intestinal cholesterol absorption.
11. Which lipoprotein is considered “protective” against CAD?
A. LDL
B. VLDL
• C. HDL
D. IDL
Rationale: HDL facilitates reverse cholesterol transport, lowering ASCVD risk.
12. Which patient should be started on statin therapy regardless of LDL level?
A. 25-year-old with LDL 120 mg/dL
• B. 55-year-old with diabetes
C. 40-year-old with HDL 65 mg/dL
D. 30-year-old with triglycerides 200 mg/dL