MMSC 433 EXAM 3 QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTION.
a "dry tap" bone marrow aspiration may be seen with what chronic myeloid
proliferative disease?
A: essential thrombocythemia
B: polycythemia vera
C: primary myelofibrosis
D: Chronic myeloid leukemia Answer - Primary myelofibrosis
what clinical feature is more often associated with essential thrombocythemia
than with the other chronic myeloproliferative disorders?
A: bleeding and thrombosis
B: infections
C: splenomegaly
D: fatigue Answer - bleeding and thromboses
what is the most common chromosomal abnormality in polycythemia vera
(PV)?
A: BCR-ABL
B: PML-RARA
,C: TET-2
D: JAK2V617F Answer - JAK2V617F
which of the following is an expected finding in polycythemia vera?
A: normal white cell count
B: anemia
C: increased RBC mass
D: low leukocyte alkaline phosphatase Answer - increased RBC mass
a patient has a normal white cell count, a moderately high platelet count, and
mild anemia. The differential shows immature granulocytes, nucleated red
cells, and teardrop-shaped red cells. Which of the following is most likely?
A: chronic myelogenous leukoemia
B: primary myelofibrosis
C: polycythemia vera
D: essential thrombocythemia Answer - primary myelofibrosis
a patient has a platelet count of 1200*10⁹/L. Many platelets are giant and have
abnormal shapes. A mild anemia is present. The bone marrow has increased
megakaryocytes in clusters; iron stores are present. Which of the following is
most likely?
A: chronic myelogenous leukemia
B: polycythemia vera
C: thrombosis secondary to blood loss
D: essential thrombocythemia Answer - essential thrombocythemia
, which one of the following chromosome abnormalities is associated with CML?
A: t(8;14)
B: trisomy 18
C: t(15;17)
D: t(9;22) Answer - t(9;22)
all of the following are minor criteria for overt PMF, except:
A: WBC count < 10*10⁹/L
B: palpable splenomegaly
C: leukoerythroblastosis
D: leukocytosis ≥ 11*10⁹/L Answer - WBC count < 10*10⁹/L
what is the treatment for Polycythemia Vera (PV)?
A: therapeutic phlebotomy
B: ruxolitinib (inhibitor of JAK2)
C: hydroxyurea
D: all answers are correct Answer - all answers are correct
hematopoietic stem cell transplantation is accepted as a cure for MDS
A: true
B: false Answer - true
COMPLETE SOLUTION.
a "dry tap" bone marrow aspiration may be seen with what chronic myeloid
proliferative disease?
A: essential thrombocythemia
B: polycythemia vera
C: primary myelofibrosis
D: Chronic myeloid leukemia Answer - Primary myelofibrosis
what clinical feature is more often associated with essential thrombocythemia
than with the other chronic myeloproliferative disorders?
A: bleeding and thrombosis
B: infections
C: splenomegaly
D: fatigue Answer - bleeding and thromboses
what is the most common chromosomal abnormality in polycythemia vera
(PV)?
A: BCR-ABL
B: PML-RARA
,C: TET-2
D: JAK2V617F Answer - JAK2V617F
which of the following is an expected finding in polycythemia vera?
A: normal white cell count
B: anemia
C: increased RBC mass
D: low leukocyte alkaline phosphatase Answer - increased RBC mass
a patient has a normal white cell count, a moderately high platelet count, and
mild anemia. The differential shows immature granulocytes, nucleated red
cells, and teardrop-shaped red cells. Which of the following is most likely?
A: chronic myelogenous leukoemia
B: primary myelofibrosis
C: polycythemia vera
D: essential thrombocythemia Answer - primary myelofibrosis
a patient has a platelet count of 1200*10⁹/L. Many platelets are giant and have
abnormal shapes. A mild anemia is present. The bone marrow has increased
megakaryocytes in clusters; iron stores are present. Which of the following is
most likely?
A: chronic myelogenous leukemia
B: polycythemia vera
C: thrombosis secondary to blood loss
D: essential thrombocythemia Answer - essential thrombocythemia
, which one of the following chromosome abnormalities is associated with CML?
A: t(8;14)
B: trisomy 18
C: t(15;17)
D: t(9;22) Answer - t(9;22)
all of the following are minor criteria for overt PMF, except:
A: WBC count < 10*10⁹/L
B: palpable splenomegaly
C: leukoerythroblastosis
D: leukocytosis ≥ 11*10⁹/L Answer - WBC count < 10*10⁹/L
what is the treatment for Polycythemia Vera (PV)?
A: therapeutic phlebotomy
B: ruxolitinib (inhibitor of JAK2)
C: hydroxyurea
D: all answers are correct Answer - all answers are correct
hematopoietic stem cell transplantation is accepted as a cure for MDS
A: true
B: false Answer - true
