HESI Admission Assessment A2 Exam 2026/2027
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Section 1: Reading Comprehension
Passage 1: The Role of Sleep in Healing
Sleep is a vital, often neglected, component of every person's overall health and well-being.
Sleep is important because it enables the body to repair and be fit and ready for another day.
Getting adequate rest may also help prevent excess weight gain, heart disease, and increased
illness duration. During sleep, the body produces cytokines, proteins that target infection and
inflammation, effectively creating an immune response. Therefore, when sleep is deprived, the
production of these protective cytokines decreases, as does the production of infection-fighting
antibodies and cells. Individuals who do not get quality sleep or enough sleep are more likely to
get sick after being exposed to a virus, such as the common cold. Furthermore, the recovery time
from illness is often prolonged in those who do not get adequate rest.
Q1: What is the main idea of the passage?
A. Cytokines are proteins that target infection.
B. Sleep deprivation leads to weight gain.
C. Adequate sleep is essential for immune function and overall health. [CORRECT]
D. Viruses like the common cold are prevented by sleep.
Correct Answer: C
Rationale: The passage discusses the various ways sleep contributes to health, specifically
focusing on the immune system, healing, and disease prevention. Option A is a detail. Option B
is mentioned but not the main focus. Option D is too specific.
Q2: According to the passage, what is the function of cytokines?
A. They help individuals gain weight.
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B. They create an immune response to infection and inflammation. [CORRECT]
C. They prevent the common cold entirely.
D. They reduce the need for sleep.
Correct Answer: B
Rationale: The text explicitly states that cytokines are proteins that "target infection and
inflammation, effectively creating an immune response."
Q3: Based on the passage, what can be inferred about a patient recovering from surgery who is
not sleeping well?
A. They will likely lose weight rapidly.
B. Their recovery time may be longer than a patient who sleeps adequately. [CORRECT]
C. They will produce too many antibodies.
D. They do not need cytokines to heal.
Correct Answer: B
Rationale: The passage states that "recovery time from illness is often prolonged in those who do
not get adequate rest." This logic can be extended to post-surgical healing.
Q4: Which of the following is a logical conclusion supported by the text?
A. People who sleep 8 hours a day never get sick.
B. Sleep is more important than diet for weight management.
C. Lack of sleep negatively impacts the body’s ability to fight infection. [CORRECT]
D. Cytokines are only produced during the day.
Correct Answer: C
Rationale: The passage states that when sleep is deprived, protective cytokines and antibodies
decrease, leading to higher susceptibility to illness.
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Q5: The word "prolonged" in the final sentence most nearly means:
A. Shortened
B. Extended [CORRECT]
C. Prevented
D. Stabilized
Correct Answer: B
Rationale: In this context, "prolonged" means to make longer in duration. Shortened is the
antonym.
Passage 2: Hypertension Management
Hypertension, or high blood pressure, is a common condition in which the long-term force of the
blood against your artery walls is high enough that it may eventually cause health problems, such
as heart disease. Blood pressure is determined both by the amount of blood your heart pumps and
the amount of resistance to blood flow in your arteries. The more blood your heart pumps and the
narrower your arteries, the higher your blood pressure. You can have high blood pressure for
years without any symptoms. Even without symptoms, damage to blood vessels and your heart
continues and can be detected. Uncontrolled high blood pressure increases your risk of serious
health problems, including heart attack and stroke. Lifestyle changes like diet and exercise are
often the first line of defense.
Q6: What is the relationship between artery width and blood pressure according to the passage?
A. Wider arteries result in higher blood pressure.
B. Narrower arteries result in lower blood pressure.
C. Narrower arteries result in higher blood pressure. [CORRECT]
D. There is no relationship between artery width and blood pressure.
Correct Answer: C
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Rationale: The passage states, "The more blood your heart pumps and the narrower your arteries,
the higher your blood pressure."
Q7: Which statement is NOT supported by the passage?
A. Hypertension can exist without noticeable symptoms.
B. Lifestyle changes can help manage blood pressure.
C. Hypertension only affects older adults. [CORRECT]
D. Uncontrolled hypertension can lead to stroke.
Correct Answer: C
Rationale: The passage does not mention age; it discusses the mechanism and risks. Options A,
B, and D are explicitly supported by the text.
Q8: The passage suggests that hypertension is dangerous primarily because:
A. It always causes severe headaches.
B. It creates resistance that damages vessels and organs over time. [CORRECT]
C. It is impossible to treat.
D. It prevents the heart from pumping blood.
Correct Answer: B
Rationale: The text mentions the "force... is high enough that it may eventually cause health
problems" and "damage to blood vessels... continues."
Q9: What does the word "uncontrolled" imply in the context of the last sentence?
A. The patient is unaware they have the condition.
B. The condition is managed effectively by medication.
C. The condition is not being managed or treated effectively. [CORRECT]
D. The blood pressure varies minute by minute.