UTA NURS 5334 PHARMACOLOGY FINAL EXAM
2026|300Qs&As VERIFIED FOR A+GRADE
A patient receiving chemotherapy for cancer experiences hair loss and nausea.
What is the main reason for these side effects?
Chemotherapy drugs are toxic to all rapidly dividing cells
How do most antineoplastic drugs achieve their effect in treating cancer?
By inhibiting DNA synthesis or function in rapidly dividing cells
How do alkylating agents primarily exert their antineoplastic effects?
By alkylating DNA, leading to cross-linking and inhibition of
replication
Which effect results from DNA cross-linking caused by alkylating agents in
cancer cells?
Inhibition of DNA replication
,What is the main mechanism of action for antimetabolite chemotherapy drugs?
Mimicking normal metabolites to inhibit DNA and RNA synthesis
In the context of antimetabolite chemotherapy, what is the primary consequence
of DNA synthesis inhibition in cancer cells?
Blocked cell division and tumor growth
Which clinical use best illustrates the action of folate analogs in cancer therapy?
Inhibiting production of tetrahydrofolate required for DNA
replication
Which of the following best describes a basic approach in the mechanism of action
of antineoplastic drugs?
Directly targeting and damaging cellular components essential for
cancer cell survival
What is the main principle of the cell kill hypothesis in cancer chemotherapy?
Each dose of chemotherapy kills a constant fraction of tumor cells.
,In cancer treatment, why is cytotoxicity a key consideration when selecting an
antineoplastic drug?
It reflects the drug’s ability to kill or damage cancer cells.
Plant alkaloids, such as vincristine and paclitaxel, primarily act by:
Disrupting microtubule dynamics during mitosis
How do vinca alkaloids primarily act to treat cancer?
Preventing microtubule polymerization
Which of the following best describes a key principle in the use of antineoplastic
drugs for cancer therapy?
Using combination therapy to target different stages of cell growth
When selecting a chemotherapy drug regimen, which factor is most important to
consider?
The type and stage of the cancer
, When selecting an antineoplastic drug regimen, why is it important to consider
the toxicity profile of each drug?
To minimize overlapping toxicities and improve patient safety.
How do targeted therapies differ from traditional chemotherapy in cancer
treatment?
Targeted therapies specifically block molecules involved in tumor
growth
Immune checkpoint inhibitors are used in cancer therapy to?
Release the brakes on the immune system to target cancer cells
Which of the following best describes the primary mechanism by which
monoclonal antibodies are used in cancer therapy?
They block specific antigens on cancer cell surfaces
2026|300Qs&As VERIFIED FOR A+GRADE
A patient receiving chemotherapy for cancer experiences hair loss and nausea.
What is the main reason for these side effects?
Chemotherapy drugs are toxic to all rapidly dividing cells
How do most antineoplastic drugs achieve their effect in treating cancer?
By inhibiting DNA synthesis or function in rapidly dividing cells
How do alkylating agents primarily exert their antineoplastic effects?
By alkylating DNA, leading to cross-linking and inhibition of
replication
Which effect results from DNA cross-linking caused by alkylating agents in
cancer cells?
Inhibition of DNA replication
,What is the main mechanism of action for antimetabolite chemotherapy drugs?
Mimicking normal metabolites to inhibit DNA and RNA synthesis
In the context of antimetabolite chemotherapy, what is the primary consequence
of DNA synthesis inhibition in cancer cells?
Blocked cell division and tumor growth
Which clinical use best illustrates the action of folate analogs in cancer therapy?
Inhibiting production of tetrahydrofolate required for DNA
replication
Which of the following best describes a basic approach in the mechanism of action
of antineoplastic drugs?
Directly targeting and damaging cellular components essential for
cancer cell survival
What is the main principle of the cell kill hypothesis in cancer chemotherapy?
Each dose of chemotherapy kills a constant fraction of tumor cells.
,In cancer treatment, why is cytotoxicity a key consideration when selecting an
antineoplastic drug?
It reflects the drug’s ability to kill or damage cancer cells.
Plant alkaloids, such as vincristine and paclitaxel, primarily act by:
Disrupting microtubule dynamics during mitosis
How do vinca alkaloids primarily act to treat cancer?
Preventing microtubule polymerization
Which of the following best describes a key principle in the use of antineoplastic
drugs for cancer therapy?
Using combination therapy to target different stages of cell growth
When selecting a chemotherapy drug regimen, which factor is most important to
consider?
The type and stage of the cancer
, When selecting an antineoplastic drug regimen, why is it important to consider
the toxicity profile of each drug?
To minimize overlapping toxicities and improve patient safety.
How do targeted therapies differ from traditional chemotherapy in cancer
treatment?
Targeted therapies specifically block molecules involved in tumor
growth
Immune checkpoint inhibitors are used in cancer therapy to?
Release the brakes on the immune system to target cancer cells
Which of the following best describes the primary mechanism by which
monoclonal antibodies are used in cancer therapy?
They block specific antigens on cancer cell surfaces
