NURS 8024 Pharm Exam 3 (antimicrobial part 2) with Complete Questions and Answers

NURS 8024 Pharm Exam 3
(antimicrobial part 2) with Complete
Questions and Answers
Bacterial protein synthesis inhibitors - ANSWER - Clindamycin


Clindamycin - ANSWER - Time dependent killing
Inhibits protein synthesis
Bacteriostatic
90% bioavailability


Clindamycin mechanism of resistance - ANSWER - Altered target sites
Active efflux (pushes drug out of the cell)


Clindamycin ADE - ANSWER - GI upset
Skin rash
Neutropenia
Superinfections such a c diff pseudomembranous
- don't use if patient has history of c diff


Clindamycin indications - ANSWER - Gram positive
Prophylaxis of endocarditis in valve patients with PCN allergy


Oxazolidinones - ANSWER - New class of bacterial protein synthesis inhibitors


Time dependent killing
Prevents formation of ribosome complex
Bacteriostatic & Bactericidal against strep

, TMP-SMX - ANSWER - Time dependent killing
Gram positive & negative organisms
UTI & resp infections, otitis media, bacterial sinusitis, pneumocystis jiroveci
pneumonia, toxoplasmosis, nocardiosis


TMP-SMX Mechanism of Resistance - ANSWER - Plasmid mediated
Reduced cell permeability so the drug can't penetrate
Reduced drug binding


TMP-SMX ADE - ANSWER - Rash
Steven Johnson syndrome
Photosensitivity
NVD
Fever, bone marrow suppression, hyperkalemia
Crystalluria & hematuria


Linezolid - ANSWER - Protein synthesis inhibitor
100% bioavailability orally
30% CSF penetration


Linezolid ADE - ANSWER - Hematologic
Increased thrombocytopenia risk
Anemia, neutropenia, neuropathy
Optic & peripheral neuropathy
Serotonin syndrome with SSRIs


Linezolid Indications - ANSWER - Gram positive resistant
VRE, HCAP, CAP