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What are the types of CNS drugs?
Able to produce full range of CNS depression
Sedatives: relax or sedate a patient (calm/soothe)
Hypnotics: induce sleep
Sedative-hypnotic: doses (low = calm, or high = sleep) determine effects
May cause physical (body) & psychological (mind) dependence
What drugs are benzodiazepines?
insomnia: temazepam & triazolam
sedation: diazepam & midazolam
What is the action of benzodiazepines?
Binds to gamma-aminobutyric acid (GABA) receptors
-> Intensifies effect of GABA (chief neuroinhibitor)
What are the uses of benzodiazepines?
Sedation
Short-term treatment of insomnia
-> ↑ total sleep time (quantity); may reduce stage IV & REM sleep (quality) = still feeling tired
when waking
What are the adverse effects of benzodiazepines?
CNS depression: dizziness & drowsiness
"Hangover" effect (i.e. daytime sleepiness)
What is a contraindication of benzodiazepines?
,Patients with narrow-angle glaucoma
-> IOP changes from altered neurotransmitter activity
What are nursing considerations for benzodiazepines?
Monitor for overdose
-> Administer flumazenil (a benzodiazepine receptor antagonist) if present
What is important to teach about benzodiazepines?
Avoid driving or other activities requiring mental alertness / physical coordination
Avoid alcohol & other CNS depressants
Do not stop drug abruptly
-> Withdrawal symptoms may occur = rebound insomnia
What drugs are barbiturates?
phenobarbital
secobarbital
What is the action of barbiturates?
Binds to gamma-aminobutyric acid (GABA) receptors
-> Intensifies effect of GABA
**Older version of benzodiazepines with more adverse effects
What are the uses of barbiturates?
Anesthesia & sedation
Rarely prescribed because of significant adverse effects & more effective drugs available
What are the adverse effects of barbiturates?
Agitation from deprived REM sleep
High risk for physical & psychological dependence
Severe withdrawal syndrome that may be fatal
Overdose: hypotension, respiratory depression, & shock
-> Maintain adequate (patent) airway, assist with ventilation, & administer oxygen
, What are contraindications of barbiturates?
Pregnancy (teratogenic effects)
Patients with significant respiratory difficulties
Patients with severe kidney/liver disease (impaired excretion and metabolism = drug buildup =
toxicity)
What are drug interactions with barbiturates?
Additive CNS depression (sedation) with alcohol, antihistamines, & opioids
↓ effectiveness of anticoagulants & oral contraceptives
-> Patients develop blood clots and get pregnant
What drugs are miscellaneous CNS depressants?
eszopiclone
ramelteon
zolpidem
What are the uses of eszopiclone, ramelteon, and zolpidem?
eszopiclone: long-term treatment of insomnia
-> Maintain sleep & ↓ early morning awakening
ramelteon: treat chronic insomnia in people who have problems falling asleep
zolpidem: long-term treatment of insomnia
-> Rapid onset in less than 30 minutes; taken immediately before bedtime (no other activities)
What are the adverse effects of eszopiclone, ramelteon, and zolpidem?
zolpidem: n/d, dizziness, & drowsiness; rebound insomnia may occur when discontinued
What are the contraindications of eszopiclone, ramelteon, and zolpidem?
ramelteon: patients with severe liver dysfunction (drug metabolism)
zolpidem: patients with impaired kidney/liver function (excretion/metabolism); cautious use in
older adults (CNS depression + already have decreased mobility = fall and injury risk)
What drugs are centrally-acting skeletal muscle relaxants?