Pharmacology Test #1: Lehne
(2026) comprehensive Questions
With Correct Verified And Well
Analyzed Answers Graded A+
Pharmacokinetics
the movement of drugs and their metabolites through the body from
absorption to excretion--what the body does to the drug
4 pharmacokinetic processes
drug absorption, drug distribution, drug metabolism, drug excretion
drug absorption
entrance of a drug into the bloodstream from its site of administration
drug distribution
passage of a drug from the blood to the tissues and cells of the body
drug metabolism
also known as bioremediation. the enzymatic alteration of drug
structure.
drug excretion
The process by which a drug and/or its waste products are eliminated
from the body. drugs can be excreted via urine, sweat, saliva, expired
air, breast milk
Overall action of pharmacokinetics
, the processes act in concert to determine the concentration of a drug
at its sites of action (receptor sites)
movement of drugs throughout the body
1. passing through channels and/or pores
2. passing through the cell membrane with aid of cell membrane
transport system
*3. penetrating the membrane directly *most common
Pharmacodynamics
what drugs do to the body and how they do it
dose-response relationship
the relationship between the size of an administered dose and the
intensity of the response produced--the higher the dose the stronger
the response
therapeutic index
the ratio of the drug's LD50 (avg lethal dose) and its ED50 (avg
effective dose) as determined by drug trials. is a measure of drug
safety.
*the wider the index the safer the drug*
receptor
any functional macromolecule in a cell which a drug binds to produce
its effects, usually reversible
cell membrane embedded enzymes
Receptors that span the cell membrane; domain is located on the cell
surface with the enzyme's catalytic site inside; response occurs in
seconds. i.e. insulin
ligand gated ion channels
Transmembrane protein that opens to allow the passage of a specific
charged ion across the membrane when a specific signal molecule
binds to the extracellular side of the protein. action occurs in
milliseconds. i.e. GABA, acetylcholine
G protein-coupled receptor systems
(2026) comprehensive Questions
With Correct Verified And Well
Analyzed Answers Graded A+
Pharmacokinetics
the movement of drugs and their metabolites through the body from
absorption to excretion--what the body does to the drug
4 pharmacokinetic processes
drug absorption, drug distribution, drug metabolism, drug excretion
drug absorption
entrance of a drug into the bloodstream from its site of administration
drug distribution
passage of a drug from the blood to the tissues and cells of the body
drug metabolism
also known as bioremediation. the enzymatic alteration of drug
structure.
drug excretion
The process by which a drug and/or its waste products are eliminated
from the body. drugs can be excreted via urine, sweat, saliva, expired
air, breast milk
Overall action of pharmacokinetics
, the processes act in concert to determine the concentration of a drug
at its sites of action (receptor sites)
movement of drugs throughout the body
1. passing through channels and/or pores
2. passing through the cell membrane with aid of cell membrane
transport system
*3. penetrating the membrane directly *most common
Pharmacodynamics
what drugs do to the body and how they do it
dose-response relationship
the relationship between the size of an administered dose and the
intensity of the response produced--the higher the dose the stronger
the response
therapeutic index
the ratio of the drug's LD50 (avg lethal dose) and its ED50 (avg
effective dose) as determined by drug trials. is a measure of drug
safety.
*the wider the index the safer the drug*
receptor
any functional macromolecule in a cell which a drug binds to produce
its effects, usually reversible
cell membrane embedded enzymes
Receptors that span the cell membrane; domain is located on the cell
surface with the enzyme's catalytic site inside; response occurs in
seconds. i.e. insulin
ligand gated ion channels
Transmembrane protein that opens to allow the passage of a specific
charged ion across the membrane when a specific signal molecule
binds to the extracellular side of the protein. action occurs in
milliseconds. i.e. GABA, acetylcholine
G protein-coupled receptor systems
