, 2024/2025 TEST BANK; PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE PRESCRIBERS, 5TH EDITION WOO
ROBINSON.COVERING CHAPTERS 1-55 QUESTIONS AND
ANSWERS WITH RATIONALES
4. Are most common in collagen tissues
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the
prescription. This is considered a loading dose. A loading dose:
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target tissues
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is
the:
1. Minimum adverse effect level
2. Peak of action
3. Onset of action
4. Therapeutic range
9. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1. When the drug has a wide therapeutic range
2. When the drug will be administered for a short time only
3. When there is a high correlation between the dose and saturation of receptor sites
4. To determine if a drug is in the therapeutic range
10. A laboratory result indicates that the peak level for a drug is above the minimum toxic
concentration. This means that the:
1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long
10. Drugs that are receptor agonists may demonstrate what property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and drug action
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
dr.j
, 2024/2025 TEST BANK; PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE PRESCRIBERS, 5TH EDITION WOO
ROBINSON.COVERING CHAPTERS 1-55 QUESTIONS AND
ANSWERS WITH RATIONALES
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs 4. An exaggerated response to competitive drug
agonists
12. Factors that affect gastric drug absorption include:
1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug 4. Ability to chew and swallow
13. Drugs administered via IV:
1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed
14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual
15. Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or
sustained-release mechanisms.
2. All brands of a drug have the same bioavailability.
3. Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4. Combining an active drug with an inert substance does not affect bioavailability.
16. Which of the following statements about the major distribution barriers (blood-brain or fetal-placental) is
true?
1. Water soluble and ionized drugs cross these barriers rapidly.
2. The blood-brain barrier slows the entry of many drugs into and from brain cells.
3. The fetal-placental barrier protects the fetus from drugs taken by the mother.
4. Lipid-soluble drugs do not pass these barriers and are safe for pregnant women.
17. Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of these
types of reactions is to:
1. Inactivate prodrugs before they can be activated by target tissues
2. Change the drugs so they can cross plasma membranes
3. Change drug molecules to a form that an excretory organ can excrete
dr.j
, 2024/2025 TEST BANK; PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE PRESCRIBERS, 5TH EDITION WOO
ROBINSON.COVERING CHAPTERS 1-55 QUESTIONS AND
ANSWERS WITH RATIONALES
4. Make these drugs more ionized and polar to facilitate excretion
18. Once they have been metabolized by the liver, the metabolites may be:
1. More active than the parent drug
2. Less active than the parent drug
3. Totally “deactivated” so they are excreted without any effect
4. All of the above
19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to excrete
drugs via the renal system would be increased by:
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease
3. Competition for a transport site by another drug 4. Unbinding a nonvolatile drug from plasma
proteins
20. Steady state is:
1. The point on the drug concentration curve when absorption exceeds excretion
2. When the amount of drug in the body remains constant
3. When the amount of drug in the body stays below the minimum toxic concentration
4. All of the above
21. Two different pain medications are given together for pain relief. The drug—drug interaction is:
1. Synergistic
2. Antagonistic
3. Potentiative
4. Additive
22. Actions taken to reduce drug—drug interaction problems include all of the following EXCEPT:
1. Reducing the dosage of one of the drugs
2. Scheduling their administration at different times
3. Prescribing a third drug to counteract the adverse reaction of the combination
4. Reducing the dosage of both drugs
23. Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements.
Which of the following would reduce or inhibit this process?
1. Protein malnutrition
2. Iron-deficiency anemia
3. Both 1 and 2
4. Neither 1 nor 2
24. The time required for the amount of drug in the body to decrease by 50% is called: 1. Steady state
2. Half-life
dr.j
ADVANCED PRACTICE NURSE PRESCRIBERS, 5TH EDITION WOO
ROBINSON.COVERING CHAPTERS 1-55 QUESTIONS AND
ANSWERS WITH RATIONALES
4. Are most common in collagen tissues
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
1. Propensity to go to the target receptor
2. Biological half-life
3. Pharmacodynamics
4. Safety and side effects
6. Azithromycin dosing requires that the first day’s dosage be twice those of the other 4 days of the
prescription. This is considered a loading dose. A loading dose:
1. Rapidly achieves drug levels in the therapeutic range
2. Requires four- to five-half-lives to attain
3. Is influenced by renal function
4. Is directly related to the drug circulating to the target tissues
7. The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is
the:
1. Minimum adverse effect level
2. Peak of action
3. Onset of action
4. Therapeutic range
9. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
1. When the drug has a wide therapeutic range
2. When the drug will be administered for a short time only
3. When there is a high correlation between the dose and saturation of receptor sites
4. To determine if a drug is in the therapeutic range
10. A laboratory result indicates that the peak level for a drug is above the minimum toxic
concentration. This means that the:
1. Concentration will produce therapeutic effects
2. Concentration will produce an adverse response
3. Time between doses must be shortened
4. Duration of action of the drug is too long
10. Drugs that are receptor agonists may demonstrate what property?
1. Irreversible binding to the drug receptor site
2. Upregulation with chronic use
3. Desensitization or downregulation with continuous use
4. Inverse relationship between drug concentration and drug action
11. Drugs that are receptor antagonists, such as beta blockers, may cause:
dr.j
, 2024/2025 TEST BANK; PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE PRESCRIBERS, 5TH EDITION WOO
ROBINSON.COVERING CHAPTERS 1-55 QUESTIONS AND
ANSWERS WITH RATIONALES
1. Downregulation of the drug receptor
2. An exaggerated response if abruptly discontinued
3. Partial blockade of the effects of agonist drugs 4. An exaggerated response to competitive drug
agonists
12. Factors that affect gastric drug absorption include:
1. Liver enzyme activity
2. Protein-binding properties of the drug molecule
3. Lipid solubility of the drug 4. Ability to chew and swallow
13. Drugs administered via IV:
1. Need to be lipid soluble in order to be easily absorbed
2. Begin distribution into the body immediately
3. Are easily absorbed if they are nonionized
4. May use pinocytosis to be absorbed
14. When a medication is added to a regimen for a synergistic effect, the combined effect of the drugs is:
1. The sum of the effects of each drug individually
2. Greater than the sum of the effects of each drug individually
3. Less than the effect of each drug individually
4. Not predictable, as it varies with each individual
15. Which of the following statements about bioavailability is true?
1. Bioavailability issues are especially important for drugs with narrow therapeutic ranges or
sustained-release mechanisms.
2. All brands of a drug have the same bioavailability.
3. Drugs that are administered more than once a day have greater bioavailability than
drugs given once daily.
4. Combining an active drug with an inert substance does not affect bioavailability.
16. Which of the following statements about the major distribution barriers (blood-brain or fetal-placental) is
true?
1. Water soluble and ionized drugs cross these barriers rapidly.
2. The blood-brain barrier slows the entry of many drugs into and from brain cells.
3. The fetal-placental barrier protects the fetus from drugs taken by the mother.
4. Lipid-soluble drugs do not pass these barriers and are safe for pregnant women.
17. Drugs are metabolized mainly by the liver via phase I or phase II reactions. The purpose of both of these
types of reactions is to:
1. Inactivate prodrugs before they can be activated by target tissues
2. Change the drugs so they can cross plasma membranes
3. Change drug molecules to a form that an excretory organ can excrete
dr.j
, 2024/2025 TEST BANK; PHARMACOTHERAPEUTICS FOR
ADVANCED PRACTICE NURSE PRESCRIBERS, 5TH EDITION WOO
ROBINSON.COVERING CHAPTERS 1-55 QUESTIONS AND
ANSWERS WITH RATIONALES
4. Make these drugs more ionized and polar to facilitate excretion
18. Once they have been metabolized by the liver, the metabolites may be:
1. More active than the parent drug
2. Less active than the parent drug
3. Totally “deactivated” so they are excreted without any effect
4. All of the above
19. All drugs continue to act in the body until they are changed or excreted. The ability of the body to excrete
drugs via the renal system would be increased by:
1. Reduced circulation and perfusion of the kidney
2. Chronic renal disease
3. Competition for a transport site by another drug 4. Unbinding a nonvolatile drug from plasma
proteins
20. Steady state is:
1. The point on the drug concentration curve when absorption exceeds excretion
2. When the amount of drug in the body remains constant
3. When the amount of drug in the body stays below the minimum toxic concentration
4. All of the above
21. Two different pain medications are given together for pain relief. The drug—drug interaction is:
1. Synergistic
2. Antagonistic
3. Potentiative
4. Additive
22. Actions taken to reduce drug—drug interaction problems include all of the following EXCEPT:
1. Reducing the dosage of one of the drugs
2. Scheduling their administration at different times
3. Prescribing a third drug to counteract the adverse reaction of the combination
4. Reducing the dosage of both drugs
23. Phase I oxidative-reductive processes of drug metabolism require certain nutritional elements.
Which of the following would reduce or inhibit this process?
1. Protein malnutrition
2. Iron-deficiency anemia
3. Both 1 and 2
4. Neither 1 nor 2
24. The time required for the amount of drug in the body to decrease by 50% is called: 1. Steady state
2. Half-life
dr.j
