NEUROBIOLOGY 5357 EXAM 1 (SUMMER 2026) | ACTUAL
QUESTIONS AND ANSWERS | WITH COMPLETE SOLUTION
What are the three major hypotheses of psychosis and their neurotransmitter
networks? Answer - Dopamine theory - hyperactive dopamine at D2 receptors
in the mesolimbic pathway
Glutamate theory - NMDA receptor hypofunction
Serotonin theory - 5HT2A receptor hyperfunction in the cortex
(Stahl Ch 4, p. 79)
Briefly explain the dopamine hypothesis of the positive and negative symptoms
of schizophrenia. Answer - The dopamine hypothesis of schizophrenia consists
of:
There is too much dopamine activity in the mesolimbic dopamine pathway,
which leads to positive symptoms (such as hallucinations and delusions).
There is also too little dopamine activity in the mesocortical dopamine
pathway, which leads to negative symptoms (such as blunting of affect, poverty
of speech, anhedonia, and so on).
What pathway is responsible for regulating dopamine in the hypothalamus and
affects the release of prolactin?
a Mesolimbic pathway
b Substantia nigra
c Mesocortical pathway
d Tuberoinfundibular pathway Answer - Tuberoinfundibular pathway
, Drug-induced Parkinson's is caused by a decrease of dopamine in what
pathway?
a Substantia nigra
b Mesolimbic pathway
c Mesocortical pathway
d Nigrostriatal pathway Answer - Nigrostriatal pathway
Brodmann's areas are differentiated by the:
a Predominant neurotransmitter
b Afferent connections
c Cellular architecture
d Cortical morphology Answer - Cellular architecture
All of the following are true about the hippocampus except that it:
a Is disrupted by frontal lobotomy
b Is involved with memory
c Contains undifferentiated stem cells
d Is smaller in some psychiatric disorders Answer - Is disrupted by frontal
lobotomy
Which of the following statements is true about the cerebellum:
Has been implicated with autism
Is similar to the motor cortex
Solely functions to support movement
Is relatively small in humans Answer - Has been implicated with autism
QUESTIONS AND ANSWERS | WITH COMPLETE SOLUTION
What are the three major hypotheses of psychosis and their neurotransmitter
networks? Answer - Dopamine theory - hyperactive dopamine at D2 receptors
in the mesolimbic pathway
Glutamate theory - NMDA receptor hypofunction
Serotonin theory - 5HT2A receptor hyperfunction in the cortex
(Stahl Ch 4, p. 79)
Briefly explain the dopamine hypothesis of the positive and negative symptoms
of schizophrenia. Answer - The dopamine hypothesis of schizophrenia consists
of:
There is too much dopamine activity in the mesolimbic dopamine pathway,
which leads to positive symptoms (such as hallucinations and delusions).
There is also too little dopamine activity in the mesocortical dopamine
pathway, which leads to negative symptoms (such as blunting of affect, poverty
of speech, anhedonia, and so on).
What pathway is responsible for regulating dopamine in the hypothalamus and
affects the release of prolactin?
a Mesolimbic pathway
b Substantia nigra
c Mesocortical pathway
d Tuberoinfundibular pathway Answer - Tuberoinfundibular pathway
, Drug-induced Parkinson's is caused by a decrease of dopamine in what
pathway?
a Substantia nigra
b Mesolimbic pathway
c Mesocortical pathway
d Nigrostriatal pathway Answer - Nigrostriatal pathway
Brodmann's areas are differentiated by the:
a Predominant neurotransmitter
b Afferent connections
c Cellular architecture
d Cortical morphology Answer - Cellular architecture
All of the following are true about the hippocampus except that it:
a Is disrupted by frontal lobotomy
b Is involved with memory
c Contains undifferentiated stem cells
d Is smaller in some psychiatric disorders Answer - Is disrupted by frontal
lobotomy
Which of the following statements is true about the cerebellum:
Has been implicated with autism
Is similar to the motor cortex
Solely functions to support movement
Is relatively small in humans Answer - Has been implicated with autism
