Antimicrobials Part 2 E X A M A C T U A L C O M P R E H E N S I V E
FREQUENTLY MOST TESTED REAL EXAM
QUESTIONS AND CORRECT ANSWERS
(VERIFIED SOLUTIONS) ALREADY GRADED A+ |
GUARANTEED SUCCESS!! NEWEST EXAM
What are the adverse drug effects of tetracyclines?
-GI discomfort
-Esophagitis
-Liver toxicity
-Photosensitivity
-Vestibular dysfunction (dizziness, vertigo, tinnitus)
-Benign intracranial hypertension (headache and blurry vision)
Can tetracyclines be given to children?
NO
-due to teeth discoloration, teeth hypoplasia, and temporary stunted growth
What are the contraindications for tetracyclines?
-Children younger than 8
-Pregnant women
-Lactating women
What new tetracycline is approved for treating acne vulgaris?
Sarecycline (Saysera)
-limited course of 12 weeks
,What do you need to have checked before starting sarecycline?
Baseline opthalmologic exam
-can cause blurred vision and a change in blue/green color perception
What is the main side effect of sarecycline?
Pseudomotor Cerebri
-benign intracranial hypertension (headache and blurry vision)
-stopping the drug reverses this
What are glycylcyclines?
Antibiotics that reversibly bind to the 30S subunit on bacteria and inhibit
protein synthesis
What is the prototype drug of the glycylcyclines?
Tigecycline (Tygacil)
-derivative of Minocycline
What is tigecycline used to treat?
-Complicated soft tissue infections
-Complicated intra-abdominal infections
-Community acquired pneumonia
,What do glycylcyclines cover?
Broad Spectrum
-MRSA
-multi-drug resistant streptococci
-VRE
-ESBL gram negative pathogens
-Acinetobacter baumanni
-many anaerobes
What do glycylcyclines not cover?
-Morganella
-Proteus
-Providencia
-Pseudomonas
How are glycylcyclines administered?
IV
Are glycylcyclines a good option for bloodstream infections?
No
-they penetrate tissues well but have a low plasma concentration
Glycylcyclines need dose reduction in patients with what condition?
Liver dx
, What are the adverse drug effects of glycylcyclines?
-N/V
-Acute pancreatitis
-Increased LFTs
-Increased creatinine
-Photosensitivity
-Pseudomotor cerebri
What are the contraindications for glycylcyclines?
-Pediatrics
-Pregnant women
-Breastfeeding women
What is the black box warning for glycylcyclines?
Death
-occurs more commonly than when using other drugs
-this drug should only be used in situations where other treatments are not an
option
What are aminoglycosides?
Antibiotics that enter through porin channels on the bacteria and bind to the 30S
subunit and inhibit protein synthesis
The efficacy of aminoglycosides is dependent on?
MIC
-the target goal is 8-10 times above the MIC
FREQUENTLY MOST TESTED REAL EXAM
QUESTIONS AND CORRECT ANSWERS
(VERIFIED SOLUTIONS) ALREADY GRADED A+ |
GUARANTEED SUCCESS!! NEWEST EXAM
What are the adverse drug effects of tetracyclines?
-GI discomfort
-Esophagitis
-Liver toxicity
-Photosensitivity
-Vestibular dysfunction (dizziness, vertigo, tinnitus)
-Benign intracranial hypertension (headache and blurry vision)
Can tetracyclines be given to children?
NO
-due to teeth discoloration, teeth hypoplasia, and temporary stunted growth
What are the contraindications for tetracyclines?
-Children younger than 8
-Pregnant women
-Lactating women
What new tetracycline is approved for treating acne vulgaris?
Sarecycline (Saysera)
-limited course of 12 weeks
,What do you need to have checked before starting sarecycline?
Baseline opthalmologic exam
-can cause blurred vision and a change in blue/green color perception
What is the main side effect of sarecycline?
Pseudomotor Cerebri
-benign intracranial hypertension (headache and blurry vision)
-stopping the drug reverses this
What are glycylcyclines?
Antibiotics that reversibly bind to the 30S subunit on bacteria and inhibit
protein synthesis
What is the prototype drug of the glycylcyclines?
Tigecycline (Tygacil)
-derivative of Minocycline
What is tigecycline used to treat?
-Complicated soft tissue infections
-Complicated intra-abdominal infections
-Community acquired pneumonia
,What do glycylcyclines cover?
Broad Spectrum
-MRSA
-multi-drug resistant streptococci
-VRE
-ESBL gram negative pathogens
-Acinetobacter baumanni
-many anaerobes
What do glycylcyclines not cover?
-Morganella
-Proteus
-Providencia
-Pseudomonas
How are glycylcyclines administered?
IV
Are glycylcyclines a good option for bloodstream infections?
No
-they penetrate tissues well but have a low plasma concentration
Glycylcyclines need dose reduction in patients with what condition?
Liver dx
, What are the adverse drug effects of glycylcyclines?
-N/V
-Acute pancreatitis
-Increased LFTs
-Increased creatinine
-Photosensitivity
-Pseudomotor cerebri
What are the contraindications for glycylcyclines?
-Pediatrics
-Pregnant women
-Breastfeeding women
What is the black box warning for glycylcyclines?
Death
-occurs more commonly than when using other drugs
-this drug should only be used in situations where other treatments are not an
option
What are aminoglycosides?
Antibiotics that enter through porin channels on the bacteria and bind to the 30S
subunit and inhibit protein synthesis
The efficacy of aminoglycosides is dependent on?
MIC
-the target goal is 8-10 times above the MIC
