Anticoagulant Pharmacology, Heparin Therapy, Low-Molecular-Weight Heparin (LMWH), Enoxaparin (Lovenox), Heparin-Induced Thrombocytopenia (HIT), Protamine Sulfate Reversal, Warfarin (Coumadin) Therapy, Vitamin K Antagonist, INR Monitoring, Major Bleeding R

Anticoagulant Pharmacology, Heparin Therapy, Low-Molecular-Weight Heparin (LMWH), Enoxaparin (Lovenox), Heparin-Induced Thrombocytopenia (HIT), Protamine Sulfate Reversal, Warfarin (Coumadin) Therapy, Vitamin K Antagonist, INR Monitoring, Major Bleeding Risk, Clopidogrel (Plavix), Antiplatelet Therapy, CYP450 Genetic Variability, Dual Antiplatelet Considerations, Alteplase (t-PA), Thrombolytic Therapy, Ischemic Stroke Management, Myocardial Infarction Treatment Window, Fibrinolysis Mechanism, Hemorrhagic Complications, Herbal Drug Interactions (Ginkgo Garlic Ginger), Pregnancy Category Risks, Epidural Hematoma Warning, Medication Safety and Monitoring, Comprehensive Antithrombotic Management Exam Questions Verified and Complete with A+ Graded Rationales Latest Updated 2026 Heparin Class Anticoagulant (Parenteral) Heparin Action/Use - No ability to dissolve clots - IV is immediate - Prevent thromembolic events - Treat conditions that need immediate anticoagulation Heparin Administration Alert - Poorly absorbs in GI - Admin: SubQ or IV - Heparin nomogram system calculates dose - Never draw back the syringe plunger once the needle has entered the skin - Never massage the site after injection - Pregnancy Category C Heparin Adverse Effects - Bleeding - Heparin-Induced Thrombocytopenia (HIT) Heparin BBW - Epidural or spina hematoma when receiving spinal anesthesia - Can result in long-term or permanent paralysis Heparin Contraindications - Active internal bleeding - Bleeding disorders - Severe HTN - Recent trauma - Intracranial hemorrhage - Bacterial endocarditis Heparin Interactions - Oral anticoagulants potentiate action - Ginger - Garlic - Green tea - Feverfew - Ginkgo Heparin OD Treatment - Protamine sulfate - IV 1 mg for ever 100 units of heparin LMWH - Enoxaparin (Lovenox) - SubQ - Duration 2-4x longer - More stable response Warfarin class - Anticoagulant - Vitamin K antagonist Warfarin Uses/Action - Prevent stroke, MI, DVT, & pulmonary embolism - S