Human Papillomavirus (HPV) and Molecular Testing for Cervical Cancer
Questions and Answers
Which of the following HPV types are most likely adequate copies of the target? - ANSWER -
to be associated with cervical cancer? - Amplification
ANSWER -16 and 18
Which of the following are associated with an
In molecular diagnostic testing, hybridization increased risk of developing cervical cancer if a
employs complementary base pair binding of a woman is infected with the HPV virus? -
synthetic strand to DNA or RNA. - ANSWER -Smoking
ANSWER -True
Which of the following statements is FALSE
Which of the following statements are true when regarding HPV vaccines/vaccination? -
describing the updated 2018 cervical screening ANSWER -Once vaccinated with an HPV
guidelines? (More than one choice may be vaccine, regular cervical cancer screening is no
correct). - ANSWER -Women under the longer required.
age of 21, should not be screened for cervical
cancer. However, screening with Pap test once a
woman becomes sexually active is In the life cycle of a human genital HPV infection,
recommended. the infection can be cleared by the body in which
of the following cases? - ANSWER -When
Women ages 21 to 29 should be screened every the infection is in surface squamous epithelial
3 years using a Pap test or liquid based cytology cells or when the infection has become
but not with HPV test. productive in the lower layers of squamous
epithelial cells.
In 2018, the USPSTF recommended using the
HPV test (hrHPV) as an option as primary
screening test for women aged 30 to 65. Which statements are true with regard the Pap
smear? - ANSWER -It screens for pre-
As an option, women aged 30-65 years can have cancerous and cancerous processes by looking
co-testing using HPV and Pap tests every five for changes to normal cervical cells.
years.
There are two main types, the conventional Pap
and the liquid-based cytology Pap.
Which FDA-approved HPV test, based on two
major processes; 1) automated specimen
preparation to simultaneously extract HPV and HPV E6 and E7 encoded proteins are important
cellular DNA and (2) PCR amplification of target for which of the following reasons? -
DNA sequences, has been given expanded FDA
ANSWER -They convert normal host cells
approval for use as a co-test or as a primary
to malignant cells
cervical cancer screening test? -
ANSWER -Cobas HPV Test
The Cervista HPV test is FDA-approved and
available in two assays; (1) a HPV screening test
What is used in many molecular assays to allow for 14 HR-HPV types and (2) a HPV assay for
for the detection of the target or to ensure
1/2
Questions and Answers
Which of the following HPV types are most likely adequate copies of the target? - ANSWER -
to be associated with cervical cancer? - Amplification
ANSWER -16 and 18
Which of the following are associated with an
In molecular diagnostic testing, hybridization increased risk of developing cervical cancer if a
employs complementary base pair binding of a woman is infected with the HPV virus? -
synthetic strand to DNA or RNA. - ANSWER -Smoking
ANSWER -True
Which of the following statements is FALSE
Which of the following statements are true when regarding HPV vaccines/vaccination? -
describing the updated 2018 cervical screening ANSWER -Once vaccinated with an HPV
guidelines? (More than one choice may be vaccine, regular cervical cancer screening is no
correct). - ANSWER -Women under the longer required.
age of 21, should not be screened for cervical
cancer. However, screening with Pap test once a
woman becomes sexually active is In the life cycle of a human genital HPV infection,
recommended. the infection can be cleared by the body in which
of the following cases? - ANSWER -When
Women ages 21 to 29 should be screened every the infection is in surface squamous epithelial
3 years using a Pap test or liquid based cytology cells or when the infection has become
but not with HPV test. productive in the lower layers of squamous
epithelial cells.
In 2018, the USPSTF recommended using the
HPV test (hrHPV) as an option as primary
screening test for women aged 30 to 65. Which statements are true with regard the Pap
smear? - ANSWER -It screens for pre-
As an option, women aged 30-65 years can have cancerous and cancerous processes by looking
co-testing using HPV and Pap tests every five for changes to normal cervical cells.
years.
There are two main types, the conventional Pap
and the liquid-based cytology Pap.
Which FDA-approved HPV test, based on two
major processes; 1) automated specimen
preparation to simultaneously extract HPV and HPV E6 and E7 encoded proteins are important
cellular DNA and (2) PCR amplification of target for which of the following reasons? -
DNA sequences, has been given expanded FDA
ANSWER -They convert normal host cells
approval for use as a co-test or as a primary
to malignant cells
cervical cancer screening test? -
ANSWER -Cobas HPV Test
The Cervista HPV test is FDA-approved and
available in two assays; (1) a HPV screening test
What is used in many molecular assays to allow for 14 HR-HPV types and (2) a HPV assay for
for the detection of the target or to ensure
1/2
