TEST BANK
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
,Table of Contents
W Q W Q
Chapter 01 Properties and Overview of Immune Respons W Q W Q W Q W Q W Q 1
es
Chapter 02 Cells and Tissues of the Immune System
W Q W Q W Q W Q W Q W Q 3
Chapter 03 Leukocyte Circulation and Migration Into Tis W Q W Q W Q W Q W Q 6
sues
Chapter 04 Innate Immunity W Q 10
Chapter 05 Antibodies and Antigens W Q W Q 17
Chapter 06 Antigen Presentation to T Lymphocytes and Functions of Major
W Q W Q W Q W Q W Q W
the Q
Histocompatibility Complex Molecules W Q W Q 20
Chapter 07 Immune Receptors and Signal Transduction
W Q W Q W Q W Q W Q W Q 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
W Q W Q W Q W Q W Q W Q W Q W Q 30
Chapter 09 Activation of T Lymphocytes
W Q W Q W Q W Q W Q 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
W Q W Q W Q W Q W Q W Q W Q W Q W Q 38
Chapter
W Q 11
W Q Differentiation and Functions of CD8+ Effector T Cells 42 W Q W Q W Q W Q W Q W Q W Q
Chapter
W Q 12W Q B Cell Activation and Antibody Production
W Q W Q 46 W Q W Q W Q
Chapter
W Q 13
W Q Effector Mechanisms of Humoral Immunity
W Q 52 W Q W Q W Q
Chapter
W Q 14
W Q Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues 56
W Q W Q W Q W Q W Q W Q W Q W Q W Q
Chapter
W Q 15
W Q Immunologic Tolerance and Autoimmunity W 62 Q W Q W Q
Chapter
W Q 16 W Q Immunity to Microbes W Q 67
W Q
Chapter
W Q 17W Q Transplantation Immunology 72 W Q
Chapter
W Q 18W Q Tumor Immunology W Q 77
Chapter
W Q 19W Q Hypersensitivity Disorders W Q 81
Chapter
W Q 20W Q Allergy 86
Chapter
W Q 21W Q Primary and Acquired Immunodeficiencies
W Q W Q W Q 89
,Chapter 01: Properties and Overview of Immune Responses
W Q W Q W Q W Q W Q W Q W Q
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
W Q W Q W Q W Q W Q W Q W Q W Q W Q
MULTIPLE CHOICE W Q
1. The principal function of the immune system is:
W Q W Q W Q W Q W Q W Q W Q
a. Defense against cancer W Q W Q
b. Repair of injured tissues W Q W Q W Q
c. Defense against microbial infections W Q W Q W Q
d. Prevention of inflammatory diseases W Q W Q W Q
e. Protection against environmental toxins W Q W Q W Q
ANS: C
The immune system has evolved in the setting of selective pressures imposed
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W
Qby microbial infections. Although immune responses to cancer may occur, the
WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
concept
that “immunosurveillance” against cancer is a principal function of the i
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
mmune s ystem is controversial. Repair of injured tissues may be a seco
W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
ndary consequence of the immune responses and inflammation. Although the
W Q WQ W Q W Q W Q W Q W Q W Q W Q
W immune system has reg ulatory features that are needed to prevent exces
Q W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q
sive inflammation, prevention of i nflammatory diseases is not a primary f
W Q W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q
unction. The immune system can protect a gainst microbial toxins, but it gen
W Q W Q W Q W Q W Q W Q WQ W Q W Q W Q W Q W Q
erally does not offer protection against toxins of
W Q W Q W Q W Q W Q W Q W Q
nonbiologic origin. W Q
2. Which of the following infectious diseases was prevented by the first
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
su ccessful vaccination?
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a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination,
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
which was against smallpox in a boy, using material from the cowpox pust
WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
ules of a mi lkmaid. In 1980, smallpox was reported to be eradicated worl
W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q
dwide by a vaccinat ion program. Effective vaccines against tetanus toxin, ru
W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q
bella virus, and poliovirus W Q W Q W Q
were developed in the 20th century and are widely used. There is no
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
effective vaccine against Mycobacterium tuberculosis. WQ W Q W Q W Q
3. Which of the following is a unique property
W Q W Q W Q W Q W Q W Q W Q W Q of the adaptive immune system?
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a. Highly diverse repertoire of specificities for W Q W Q W Q W Q W Q W Q antigens
b. Self-nonself discrimination W Q
c. Recognition of microbial structures by both W Q W Q W Q W Q W Q W Q cell-associated and soluble receptors W Q W Q W Q
d. Protection against viral infections W Q W Q W Q
e. Responses that have the same kinetics and W Q W Q W Q W Q W Q W Q W Q magnitude on repeated W Q W Q W Q
exposur e to the same microbe WQ W Q W Q W Q W Q
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphoc
WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ
ytes, which are the central cellular components of the adaptive immune
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
system. Both the innate and the adaptive immune systems use cell-
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
associated and soluble receptors to recognize microbes, display some degree
W Q W Q W Q W Q W Q W Q W Q W Q W Q
W of sel f-
Q W Q WQ
nonself discrimination, and protect against viruses. On repeated exposure to t
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
he sa me microbe, the adaptive immune response becomes more rapid and of greater m
W Q WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ W Q
agnitude; this is the manifestation of memory. W Q W Q W Q W Q W Q W Q
4. Antibodies and T lymphocytes are the respective mediators of which t W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
wo types of immunity?
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a. Innate and adaptive W Q W Q
b. Passive and active W Q W Q
c. Specific and nonspecific W Q W Q
d. Humoral and cell-mediated W Q W Q
e. Adult and neonatal W Q W Q
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B lym p
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hocytes produce antibodies, which are the recognition and effector molecules of h
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q WQ
umoral immune responses to extracellular pathogens. T cells recognize and
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
promote
eradication of intracellular pathogens in cell- W Q W Q W Q W Q W Q
mediated immunity. Passive and active immunity both can be mediated by
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
either B or T lymphocytes. Specific immunity is another term for adaptive
W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W
Qimmunity. Both B and T lymphocytes participate in adult adaptive immunit W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
y but are still developin g in the neonatal period.
W Q W Q W Q W Q WQ W Q W Q W Q W Q
5. The two major functional classes of effector T lymphocytes are:
W Q W Q W Q W Q W Q W Q W Q W Q W Q
a. Helper T lymphocytes and cytotoxic T lymphocytes W Q W Q W Q W Q W Q W Q
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes W Q W Q W Q W Q
c. Memory T cells and effector T cells W Q W Q W Q W Q W Q W Q
d. Helper cells and antigen-presenting cells W Q W Q W Q W Q
e. Cytotoxic T lymphocytes and target cells W Q W Q W Q W Q W Q
ANS: A
T cells can be classified into effector subsets that perform different effector f
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
unctio ns. Most effector T cells are either helper T lymphocytes, which e
WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
nhance the res ponses of other immune cells, including phagocytes and B
W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W
Qcells, to infections, or cytotoxic T lymphocytes, which directly kill infecte
W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q
d cells. Natural killer cells are
W Q W Q W Q W Q W Q
not T lymphocyte W Q W Q
s.
Antigen-
presenting cells usually are not T cells. Memory T cells are not effector T cell
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
s.
6. Which of the following cell types is required for all adaptive humoral immune r
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
esponse s? WQ
a. Natural killer cells W Q W Q
b. Dendritic cells W Q
c. Cytolytic T lymphocytes W Q W Q
d. B lymphocytes W Q
e. Helper T lymphocytes W Q W Q
Cellular and Molecular Immunology
Abul Abbas, Andrew Lichtman, and Shiv Pillai
10th Edition
,Table of Contents
W Q W Q
Chapter 01 Properties and Overview of Immune Respons W Q W Q W Q W Q W Q 1
es
Chapter 02 Cells and Tissues of the Immune System
W Q W Q W Q W Q W Q W Q 3
Chapter 03 Leukocyte Circulation and Migration Into Tis W Q W Q W Q W Q W Q 6
sues
Chapter 04 Innate Immunity W Q 10
Chapter 05 Antibodies and Antigens W Q W Q 17
Chapter 06 Antigen Presentation to T Lymphocytes and Functions of Major
W Q W Q W Q W Q W Q W
the Q
Histocompatibility Complex Molecules W Q W Q 20
Chapter 07 Immune Receptors and Signal Transduction
W Q W Q W Q W Q W Q W Q 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
W Q W Q W Q W Q W Q W Q W Q W Q 30
Chapter 09 Activation of T Lymphocytes
W Q W Q W Q W Q W Q 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
W Q W Q W Q W Q W Q W Q W Q W Q W Q 38
Chapter
W Q 11
W Q Differentiation and Functions of CD8+ Effector T Cells 42 W Q W Q W Q W Q W Q W Q W Q
Chapter
W Q 12W Q B Cell Activation and Antibody Production
W Q W Q 46 W Q W Q W Q
Chapter
W Q 13
W Q Effector Mechanisms of Humoral Immunity
W Q 52 W Q W Q W Q
Chapter
W Q 14
W Q Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues 56
W Q W Q W Q W Q W Q W Q W Q W Q W Q
Chapter
W Q 15
W Q Immunologic Tolerance and Autoimmunity W 62 Q W Q W Q
Chapter
W Q 16 W Q Immunity to Microbes W Q 67
W Q
Chapter
W Q 17W Q Transplantation Immunology 72 W Q
Chapter
W Q 18W Q Tumor Immunology W Q 77
Chapter
W Q 19W Q Hypersensitivity Disorders W Q 81
Chapter
W Q 20W Q Allergy 86
Chapter
W Q 21W Q Primary and Acquired Immunodeficiencies
W Q W Q W Q 89
,Chapter 01: Properties and Overview of Immune Responses
W Q W Q W Q W Q W Q W Q W Q
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
W Q W Q W Q W Q W Q W Q W Q W Q W Q
MULTIPLE CHOICE W Q
1. The principal function of the immune system is:
W Q W Q W Q W Q W Q W Q W Q
a. Defense against cancer W Q W Q
b. Repair of injured tissues W Q W Q W Q
c. Defense against microbial infections W Q W Q W Q
d. Prevention of inflammatory diseases W Q W Q W Q
e. Protection against environmental toxins W Q W Q W Q
ANS: C
The immune system has evolved in the setting of selective pressures imposed
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W
Qby microbial infections. Although immune responses to cancer may occur, the
WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
concept
that “immunosurveillance” against cancer is a principal function of the i
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
mmune s ystem is controversial. Repair of injured tissues may be a seco
W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
ndary consequence of the immune responses and inflammation. Although the
W Q WQ W Q W Q W Q W Q W Q W Q W Q
W immune system has reg ulatory features that are needed to prevent exces
Q W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q
sive inflammation, prevention of i nflammatory diseases is not a primary f
W Q W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q
unction. The immune system can protect a gainst microbial toxins, but it gen
W Q W Q W Q W Q W Q W Q WQ W Q W Q W Q W Q W Q
erally does not offer protection against toxins of
W Q W Q W Q W Q W Q W Q W Q
nonbiologic origin. W Q
2. Which of the following infectious diseases was prevented by the first
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
su ccessful vaccination?
W Q W Q
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C
In 1798, Edward Jenner reported the first intentional successful vaccination,
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
which was against smallpox in a boy, using material from the cowpox pust
WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
ules of a mi lkmaid. In 1980, smallpox was reported to be eradicated worl
W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q
dwide by a vaccinat ion program. Effective vaccines against tetanus toxin, ru
W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q
bella virus, and poliovirus W Q W Q W Q
were developed in the 20th century and are widely used. There is no
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
effective vaccine against Mycobacterium tuberculosis. WQ W Q W Q W Q
3. Which of the following is a unique property
W Q W Q W Q W Q W Q W Q W Q W Q of the adaptive immune system?
W Q W Q W Q W Q
a. Highly diverse repertoire of specificities for W Q W Q W Q W Q W Q W Q antigens
b. Self-nonself discrimination W Q
c. Recognition of microbial structures by both W Q W Q W Q W Q W Q W Q cell-associated and soluble receptors W Q W Q W Q
d. Protection against viral infections W Q W Q W Q
e. Responses that have the same kinetics and W Q W Q W Q W Q W Q W Q W Q magnitude on repeated W Q W Q W Q
exposur e to the same microbe WQ W Q W Q W Q W Q
ANS: A
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphoc
WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ
ytes, which are the central cellular components of the adaptive immune
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
system. Both the innate and the adaptive immune systems use cell-
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
associated and soluble receptors to recognize microbes, display some degree
W Q W Q W Q W Q W Q W Q W Q W Q W Q
W of sel f-
Q W Q WQ
nonself discrimination, and protect against viruses. On repeated exposure to t
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
he sa me microbe, the adaptive immune response becomes more rapid and of greater m
W Q WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ WQ W Q
agnitude; this is the manifestation of memory. W Q W Q W Q W Q W Q W Q
4. Antibodies and T lymphocytes are the respective mediators of which t W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
wo types of immunity?
W Q W Q W Q
a. Innate and adaptive W Q W Q
b. Passive and active W Q W Q
c. Specific and nonspecific W Q W Q
d. Humoral and cell-mediated W Q W Q
e. Adult and neonatal W Q W Q
ANS: D
Both B and T lymphocytes are principal components of adaptive immunity. B lym p
W Q W Q W Q W Q W Q WQ W Q W Q WQ WQ W Q WQ WQ
hocytes produce antibodies, which are the recognition and effector molecules of h
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q WQ
umoral immune responses to extracellular pathogens. T cells recognize and
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
promote
eradication of intracellular pathogens in cell- W Q W Q W Q W Q W Q
mediated immunity. Passive and active immunity both can be mediated by
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
either B or T lymphocytes. Specific immunity is another term for adaptive
W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W
Qimmunity. Both B and T lymphocytes participate in adult adaptive immunit W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
y but are still developin g in the neonatal period.
W Q W Q W Q W Q WQ W Q W Q W Q W Q
5. The two major functional classes of effector T lymphocytes are:
W Q W Q W Q W Q W Q W Q W Q W Q W Q
a. Helper T lymphocytes and cytotoxic T lymphocytes W Q W Q W Q W Q W Q W Q
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes W Q W Q W Q W Q
c. Memory T cells and effector T cells W Q W Q W Q W Q W Q W Q
d. Helper cells and antigen-presenting cells W Q W Q W Q W Q
e. Cytotoxic T lymphocytes and target cells W Q W Q W Q W Q W Q
ANS: A
T cells can be classified into effector subsets that perform different effector f
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
unctio ns. Most effector T cells are either helper T lymphocytes, which e
WQ W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
nhance the res ponses of other immune cells, including phagocytes and B
W Q W Q WQ W Q W Q W Q W Q W Q W Q W Q W Q W
Qcells, to infections, or cytotoxic T lymphocytes, which directly kill infecte
W Q W Q W Q WQ W Q W Q W Q W Q W Q W Q
d cells. Natural killer cells are
W Q W Q W Q W Q W Q
not T lymphocyte W Q W Q
s.
Antigen-
presenting cells usually are not T cells. Memory T cells are not effector T cell
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
s.
6. Which of the following cell types is required for all adaptive humoral immune r
W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q W Q
esponse s? WQ
a. Natural killer cells W Q W Q
b. Dendritic cells W Q
c. Cytolytic T lymphocytes W Q W Q
d. B lymphocytes W Q
e. Helper T lymphocytes W Q W Q
