Lehne's Pharmacology for Nursing Care -
Elsevier e-Book on VitalSource, 12th
Edition
by Jacqueline Rosenjack Burchum, DNSc,
FNP-BC, CNE and Laura D. Rosenthal, DNP,
RN, ACNP-BC, FAANP
TEST BANK
Lehne’s Pharmacology for Nursing Care, 12th Edition
UNIT I: Introduction
Chapter 1 – Orientation to Pharmacology
Chapter 1: Orientation to Pharmacology
20 High-Yield Nursing MCQs
1. Which statement best defines pharmacology in nursing
practice?
,A. The study of drug costs and availability
B. The science of drug actions and their effects on the body
C. The legal regulation of medications
D. The preparation and dispensing of drugs
Correct Answer: B
Rationale: Pharmacology focuses on how drugs act in the body
and the resulting effects, forming the foundation for safe
nursing medication administration.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
2. A nurse explains that pharmacokinetics refers to which
process?
A. What drugs do to the body
B. Drug-receptor binding
C. What the body does to a drug
D. Drug safety monitoring
Correct Answer: C
Rationale: Pharmacokinetics describes absorption, distribution,
metabolism, and excretion—how the body handles a drug.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
3. Which concept describes drug-receptor interactions leading
to a physiologic response?
,A. Pharmacokinetics
B. Pharmacodynamics
C. Toxicology
D. Pharmacoeconomics
Correct Answer: B
Rationale: Pharmacodynamics examines mechanisms of action
and drug-receptor interactions that produce effects.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
4. Which factor has the greatest influence on drug absorption?
A. Drug brand name
B. Route of administration
C. Patient age
D. Drug cost
Correct Answer: B
Rationale: Route of administration directly affects the speed
and extent of drug absorption.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
5. The nurse identifies first-pass metabolism as occurring
primarily in the:
A. Kidneys
B. Lungs
, C. Liver
D. Small intestine
Correct Answer: C
Rationale: First-pass metabolism occurs when orally
administered drugs are metabolized by the liver before reaching
systemic circulation.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
6. Which term describes the movement of drugs from blood to
tissues?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B
Rationale: Distribution refers to drug movement from the
bloodstream into tissues and organs.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
7. Why are drugs that are highly protein-bound clinically
significant?
A. They are excreted faster
B. They have reduced therapeutic effects
Elsevier e-Book on VitalSource, 12th
Edition
by Jacqueline Rosenjack Burchum, DNSc,
FNP-BC, CNE and Laura D. Rosenthal, DNP,
RN, ACNP-BC, FAANP
TEST BANK
Lehne’s Pharmacology for Nursing Care, 12th Edition
UNIT I: Introduction
Chapter 1 – Orientation to Pharmacology
Chapter 1: Orientation to Pharmacology
20 High-Yield Nursing MCQs
1. Which statement best defines pharmacology in nursing
practice?
,A. The study of drug costs and availability
B. The science of drug actions and their effects on the body
C. The legal regulation of medications
D. The preparation and dispensing of drugs
Correct Answer: B
Rationale: Pharmacology focuses on how drugs act in the body
and the resulting effects, forming the foundation for safe
nursing medication administration.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
2. A nurse explains that pharmacokinetics refers to which
process?
A. What drugs do to the body
B. Drug-receptor binding
C. What the body does to a drug
D. Drug safety monitoring
Correct Answer: C
Rationale: Pharmacokinetics describes absorption, distribution,
metabolism, and excretion—how the body handles a drug.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
3. Which concept describes drug-receptor interactions leading
to a physiologic response?
,A. Pharmacokinetics
B. Pharmacodynamics
C. Toxicology
D. Pharmacoeconomics
Correct Answer: B
Rationale: Pharmacodynamics examines mechanisms of action
and drug-receptor interactions that produce effects.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
4. Which factor has the greatest influence on drug absorption?
A. Drug brand name
B. Route of administration
C. Patient age
D. Drug cost
Correct Answer: B
Rationale: Route of administration directly affects the speed
and extent of drug absorption.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
5. The nurse identifies first-pass metabolism as occurring
primarily in the:
A. Kidneys
B. Lungs
, C. Liver
D. Small intestine
Correct Answer: C
Rationale: First-pass metabolism occurs when orally
administered drugs are metabolized by the liver before reaching
systemic circulation.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
6. Which term describes the movement of drugs from blood to
tissues?
A. Absorption
B. Distribution
C. Metabolism
D. Excretion
Correct Answer: B
Rationale: Distribution refers to drug movement from the
bloodstream into tissues and organs.
Citation: Lehne’s Pharmacology for Nursing Care, 12th ed., Ch. 1
7. Why are drugs that are highly protein-bound clinically
significant?
A. They are excreted faster
B. They have reduced therapeutic effects
