AAMC FL 1 FULL REVIEW- Bio/Biochem Test Questions with Answers
Rated A
Based on the data presented in the passage, also: The larger HSP110 T17 deletions cause
which statement best describes the HSP110ΔE9 Exon 9 to be omitted from the final sequence
allele? during pre-mRNA processing. This generates a
premature stop codon in Exon 10, resulting in the
A.Cancer-promoting and dominant to mutant protein HSP110ΔE9.
HSP110WT
B.Cancer-promoting and recessive to You're going to have MORE PRE-MATURE
HSP110WT transcripts, SO LESS mature ones.
C.Cancer-suppressing and dominant to
HSP110WT
D.Cancer-suppressing and recessive to
HSP110WT - ANSWER -Cross out A and A man with a CRC mutation that results in the
B. LOOK AT THE FIGURE! Tumor volume is synthesis of HSP110ΔE9 and a woman that does
DOWN. not carry this mutation in any of her tissues have
a child. What is the percent chance that the child
Table 2 shows that HSP110ΔE9 allele when will inherit the CRC mutation?
mixed with HSP110WT there is more apoptotic
cells. So it's dominant. A.0%
B.25%
SLOW THE HECK DOWN AND READ C.50%
D.100%
passage: People with MSI CRC have
Based on the passage, in MSI CRC primary HSP110ΔE9 transcripts in cancerous tissue only.
tumor cells, the size of the deletion in the - ANSWER -YOU AINT GONNA PASS
HSP110 T17 microsatellite is inversely correlated DOWN CANCEROUS TISSUE
with:
A!
A.the amount of HSP110ΔE9 protein expressed.
B.the number of mature HSP110WT transcripts
synthesized. Which nucleotide pairing(s) would be recognized
by the MMR system during DNA replication?
C.the frequency of the omission of HSP110 Exon
9 during splicing. dTMP and dCMP
dGMP and dAMP
D.the extent of premature translation termination dAMP and dTMP
in Exon 10. - ANSWER -INVERSELY
CORRELATED WITH A.I only
B.III only
According to Table 1, as the size of the deletion C.I and II only
increases, the amount of HSP110ΔE9 and D.I, II, and III - ANSWER -Looking for
HSP110WT transcripts synthesized increase and mismatched bases!
decrease, respectively.
Roman numeral 2 comes up twice so start there.
, AAMC FL 1 FULL REVIEW- Bio/Biochem Test Questions with Answers
Rated A
G and A are not paired correctly (cross out a and A.Phenylalanine
b) B.Lysine
C.Arginine
Now looking at 3. Adenine and Thymine are D.Glutamate - ANSWER -A. only one that is
paired together normally, eliminate D, end with neutral and aromatic!
C.
Based on the information in the passage, a
The information in the passage best supports the mature AT1 mRNA is most likely to contain a
conclusion that Intron 8 of HSP110 most likely sequence coding for which genetic factor(s)?
contains which of the following?
A.Signal sequence
A.Stop codon B.Introns
B.Splice acceptor site C.Promoter
C.HSP110 gene promoter D.Nuclear localization signal
D.Partial coding sequence of HSP110 -
ANSWER -Introns are useless pieces of Passage: AT1 localization to the luminal plasma
shit membrane of small intestinal epithelial cells. AT1
simultaneously transports tryptophan against its
only think it will have is a place for the splice concentration gradient and a sodium ion along its
some to come and crunch it. concentration gradient into the cytoplasm of
intestinal epithelial cells. - ANSWER -Aight.
So we know this sucker is a transmembrane
protein transporter. They transport ish by a signal
According to the information in the passage, sequence (A).
HSP110 is most likely which type of protein?
A nuclear localization signal permits proteins to
A.Adhesion enter the nucleus. This is NOT likely for a
B.Chaperone transmembrane protein (D).
C.Clathrin
D.Enzyme
Passage: HSP110 can bind structurally similar Which effect did a protein-free diet have on DSS-
heat shock proteins and functions to facilitate treated +/y and -/y mice, respectively?
proper protein folding and to reduce levels of
nonfunctional protein aggregates. - A.Both the +/y and the -/y mice gained weight.
ANSWER -FACILITATING PROTEIN B.The +/y mice lost weight, and the -/y mice
FOLDING = CHAPERONE gained weight.
C.The +/y mice gained weight, and the -/y mice
lost weight.
D.Both +/y and the -/y mice lost weight. -
Which amino acid, in addition to tryptophan, is ANSWER -You read the table. You rock. D.
most likely to be transported by AT1?
Rated A
Based on the data presented in the passage, also: The larger HSP110 T17 deletions cause
which statement best describes the HSP110ΔE9 Exon 9 to be omitted from the final sequence
allele? during pre-mRNA processing. This generates a
premature stop codon in Exon 10, resulting in the
A.Cancer-promoting and dominant to mutant protein HSP110ΔE9.
HSP110WT
B.Cancer-promoting and recessive to You're going to have MORE PRE-MATURE
HSP110WT transcripts, SO LESS mature ones.
C.Cancer-suppressing and dominant to
HSP110WT
D.Cancer-suppressing and recessive to
HSP110WT - ANSWER -Cross out A and A man with a CRC mutation that results in the
B. LOOK AT THE FIGURE! Tumor volume is synthesis of HSP110ΔE9 and a woman that does
DOWN. not carry this mutation in any of her tissues have
a child. What is the percent chance that the child
Table 2 shows that HSP110ΔE9 allele when will inherit the CRC mutation?
mixed with HSP110WT there is more apoptotic
cells. So it's dominant. A.0%
B.25%
SLOW THE HECK DOWN AND READ C.50%
D.100%
passage: People with MSI CRC have
Based on the passage, in MSI CRC primary HSP110ΔE9 transcripts in cancerous tissue only.
tumor cells, the size of the deletion in the - ANSWER -YOU AINT GONNA PASS
HSP110 T17 microsatellite is inversely correlated DOWN CANCEROUS TISSUE
with:
A!
A.the amount of HSP110ΔE9 protein expressed.
B.the number of mature HSP110WT transcripts
synthesized. Which nucleotide pairing(s) would be recognized
by the MMR system during DNA replication?
C.the frequency of the omission of HSP110 Exon
9 during splicing. dTMP and dCMP
dGMP and dAMP
D.the extent of premature translation termination dAMP and dTMP
in Exon 10. - ANSWER -INVERSELY
CORRELATED WITH A.I only
B.III only
According to Table 1, as the size of the deletion C.I and II only
increases, the amount of HSP110ΔE9 and D.I, II, and III - ANSWER -Looking for
HSP110WT transcripts synthesized increase and mismatched bases!
decrease, respectively.
Roman numeral 2 comes up twice so start there.
, AAMC FL 1 FULL REVIEW- Bio/Biochem Test Questions with Answers
Rated A
G and A are not paired correctly (cross out a and A.Phenylalanine
b) B.Lysine
C.Arginine
Now looking at 3. Adenine and Thymine are D.Glutamate - ANSWER -A. only one that is
paired together normally, eliminate D, end with neutral and aromatic!
C.
Based on the information in the passage, a
The information in the passage best supports the mature AT1 mRNA is most likely to contain a
conclusion that Intron 8 of HSP110 most likely sequence coding for which genetic factor(s)?
contains which of the following?
A.Signal sequence
A.Stop codon B.Introns
B.Splice acceptor site C.Promoter
C.HSP110 gene promoter D.Nuclear localization signal
D.Partial coding sequence of HSP110 -
ANSWER -Introns are useless pieces of Passage: AT1 localization to the luminal plasma
shit membrane of small intestinal epithelial cells. AT1
simultaneously transports tryptophan against its
only think it will have is a place for the splice concentration gradient and a sodium ion along its
some to come and crunch it. concentration gradient into the cytoplasm of
intestinal epithelial cells. - ANSWER -Aight.
So we know this sucker is a transmembrane
protein transporter. They transport ish by a signal
According to the information in the passage, sequence (A).
HSP110 is most likely which type of protein?
A nuclear localization signal permits proteins to
A.Adhesion enter the nucleus. This is NOT likely for a
B.Chaperone transmembrane protein (D).
C.Clathrin
D.Enzyme
Passage: HSP110 can bind structurally similar Which effect did a protein-free diet have on DSS-
heat shock proteins and functions to facilitate treated +/y and -/y mice, respectively?
proper protein folding and to reduce levels of
nonfunctional protein aggregates. - A.Both the +/y and the -/y mice gained weight.
ANSWER -FACILITATING PROTEIN B.The +/y mice lost weight, and the -/y mice
FOLDING = CHAPERONE gained weight.
C.The +/y mice gained weight, and the -/y mice
lost weight.
D.Both +/y and the -/y mice lost weight. -
Which amino acid, in addition to tryptophan, is ANSWER -You read the table. You rock. D.
most likely to be transported by AT1?
