NURSING MSN 571 ADVANCED
PATHOPHYSIOLOGY AND CLINICAL
APPLICATIONS EXAM
⫸ Drug Selection. Answer; includes analysis of cost, guidelines,
avaibalbility, interactions, side effects, allergies, hepatic and renal
function, need for monitoring, special precautions i.e elderly
⫸ medication education basic components. Answer; medication name
purpose
dosing regimen
administration
adverse effects
any storage needs
associated labs testing
food & drug interactions
duration of therapy
⫸ medication adherence. Answer; barriers to adherence=
forgetfulness
lack of planning
cost
, dissatisfaction
altered dosing
⫸ Phamacokinetics. Answer; study of drug movement throughout body
⫸ principles of pharmacokinetics. Answer; absorption
distribution
metabolism
excretion
⫸ Passage of drugs across membranes. Answer; - channels and pores
- transport systems (P-glycoprotein)
- direct penetration of the membrane
⫸ Absorption of drugs. Answer; Transfer of drugs from site of
administration across cell membrane into the blood stream
⫸ factors that affect absorption of drugs. Answer; rate of dissolution-
how easy dissolves
surface area- >surface area moves faster
blood flow- >blood flow moves faster
lipid solubility - lipid easily cross membrane
ph partitioning -
PATHOPHYSIOLOGY AND CLINICAL
APPLICATIONS EXAM
⫸ Drug Selection. Answer; includes analysis of cost, guidelines,
avaibalbility, interactions, side effects, allergies, hepatic and renal
function, need for monitoring, special precautions i.e elderly
⫸ medication education basic components. Answer; medication name
purpose
dosing regimen
administration
adverse effects
any storage needs
associated labs testing
food & drug interactions
duration of therapy
⫸ medication adherence. Answer; barriers to adherence=
forgetfulness
lack of planning
cost
, dissatisfaction
altered dosing
⫸ Phamacokinetics. Answer; study of drug movement throughout body
⫸ principles of pharmacokinetics. Answer; absorption
distribution
metabolism
excretion
⫸ Passage of drugs across membranes. Answer; - channels and pores
- transport systems (P-glycoprotein)
- direct penetration of the membrane
⫸ Absorption of drugs. Answer; Transfer of drugs from site of
administration across cell membrane into the blood stream
⫸ factors that affect absorption of drugs. Answer; rate of dissolution-
how easy dissolves
surface area- >surface area moves faster
blood flow- >blood flow moves faster
lipid solubility - lipid easily cross membrane
ph partitioning -
