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Pharmacology HESI RN 2025/2026 – Questions and Answers (A+ Grade)Pharmacology HESI RN – Exam Practice

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This document contains a complete set of Pharmacology HESI RN questions with verified answers for the 2025/2026 academic year. It covers essential pharmacology topics for registered nursing practice, including drug classifications, mechanisms of action, therapeutic uses, adverse effects, contraindications, interactions, and patient education. The material provides detailed rationales to strengthen understanding, enhance clinical reasoning, and improve exam readiness. Ideal for focused review, self-assessment, and confident preparation for the Pharmacology HESI RN exam.

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Pharmacology HESI RN

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Pharmacology HESI RN questions and answers
2025\2026 A+ Grade

Methadone
- correct answer pain management, heroine patients that need to be transitioned into sobriety



Cyclobenzaprine (Flexural)
- correct answer Muscle relaxant/antispasmodic, Physical dependence - do not d/c abruptly



Methocarbamol (Robaxin), Baclofen (Lioresal)
- correct answer Muscle Relaxant



Benzodiazepines withdrawal symptoms
- correct answer tremors, sweating, agitation, nervousness



Methylphenidate (Ritalin), amphetamine/dexaphetamine (Adderall)
- correct answer used to help symptoms of ADD/ADHA, side effects include racing heartrate, thirst, and
reduced hunger



Sumatriptan (Imitrex) and Fioricet
- correct answer used to treat migraines



Valporic Acid
- correct answer Anticonvulsant - don't give to children, the side and adverse effects include sedation,
dizziness, ataxia, and confusion. When the client is taking this medication as a single daily dose,
administering it at bedtime negates the risk of injury from sedation and enhances client safety.
Otherwise, it may be given after meals to avoid gastrointestinal upset.



Phenobarbital (Luminal)
- correct answer Anticonvulsant/Hypnotic; tonic-clonic and partial seizures; the longest acting of
common barbiturates; combined with other drugs; adverse reactions: drowsiness, nystagmus, ataxia,
paradoxical excitement; therapeutic levels: 15-60mcg/ml; avoid rapid infusion, monitor BP

, Keppra (levetiracetam)
- correct answer Anticonvulsant, kid friendly



Phenytoin (Dilantin)
- correct answer Anticonvulsant. SEs: Nysagmus, diplopia, EOM palsies, ataxia, gingival hyperplasia.



Gabapentin (Neurontin)
- correct answer An anticonvulsant used to treat neuropathic pain, with super high doses good for
anxiety, the patient will be drowsy, given with other anticonvulsant drugs



Pregabalin (Lyrica)
- correct answer used to treat neuropathic pain



Loratidine (Claritin), Cetrizine (Zyrtec)
- correct answer antihistamines, tx for allergies



Benzonatate (Tessalon Perles), Codeine, dextromethorphan
- correct answer antitussives helps to reduce cough



Guaifenesin (Mucinex)
- correct answer Category: Expectorant, Use: Productive and nonproductive cough, Precautions:
Increase fluids if possible



Pseudoephedrine (Sudafed)
- correct answer decongestant (alpha-1 adrenergic agonist)



Oxymetazoline (Afrin)
- correct answer nasal decongestant; may cause rebound congestion if used for more than 3-5 days



Warfarin (Coumadin)
- correct answer Anticoagulant that thins the blood, need to check INR/PT blood values, antidote is
vitamin k, if showing signs of bleeding check your INR, limit leafy green vegetables

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