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Pharmacology II HESI – Exam Practice 2025/2026 A+ GradeHESI Pharmacology II 2025/2026 – Questions and Answers (A+ Grade)

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This document contains a complete set of HESI Pharmacology II questions with verified answers for the 2025/2026 academic year. It covers essential pharmacology topics including drug classifications, mechanisms of action, therapeutic uses, adverse effects, contraindications, interactions, and patient education across multiple nursing specialties. The material provides detailed rationales to strengthen understanding, reinforce critical thinking, and enhance exam readiness. Ideal for focused review, self-assessment, and confident preparation for the HESI Pharmacology II exam.

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Pharm II HESI questions and answers 2025\2026
A+ Grade

Which of the following is a rapid acting insulin and should be administered immediately before a meal?

A. Glargine

B. Aspart (Lispro)

C. NPH

D. Regular
- correct answer B. Aspart

rationale: onset is 5 minutes

Glargine=Lantus (long lasting)



A PT has an anaphylactic allergy to sulfa drugs. She receives sulfamethoxazole. She becomes flushed and
SOB. Her HR is normal but her BP is dropping. You first administer

A. Epinephrine

B. Diphenhydramine

C. Albuterol

D. Atropine
- correct answer A. Epi

rationale: raises BP



Which of the following would be an adverse effect of methimazole (Tapazole)

A. Tachycardia

B. Bradycardia

C. SOB

D. Arrhythmias
- correct answer This is an anti-thyroid medication

B. Bradycardia

,One of your PTs is started on verapamil (Calan). Before administering the dose you check

A. HR

B. urine output

C. weight

D. temp
- correct answer this is a calcium channel blocker--worried about HR

A. HR



One of your PTs is to be started on iron sulfate therapy. You instruct him to:

A. take with meals

B. take on empty stomach

C. remain upright for at least 60 min following administration

D. take with vitamin A to increase absorption
- correct answer B. take on empty stomach

rationale: taking with food lessens absorption, but it can cause upset stomach so most like to take with
food

take iron with vitamin C to increase absorption

liquid iron-drink through straw bc it can stain teeth black



which of the following should be considered when administering IV potassium?

A. Max rate infused through central line is 20 meq/h

B. Max rate infused through peripheral line is 10 meq/h

C. Max concentration through a central line is 20 meq/50ml

D. Max concentration through peripheral line is 10 meq/100ml

E. all of the above
- correct answer E. all of the above

will usually be infused peripherally



which is the following agents is used to treat MG

, A. Atropine (anticholinergic)

B. Pyridostigmine (Mestinon-acetylcholinesterase inhibitor)

C. Metoprolol (Lopressor-beta blocker)

D. Albuterol (Proventil-beta 2 agonist)
- correct answer B. Pyridostigmine

rationale: Atropine is emergency drug for bradycardia



which of the following would you monitor for patients started on a narcotic like morphine?

A. HR

B. respiratory rate

C. liver function tests

D. creatine phosphokinase (CPK)
- correct answer A. HR



PT is receiving baclofen (Lioresal). This medication can cause

A. sedation

B. seizures

C. none of the above

D. all of the above
- correct answer this is a skeletal muscle relaxer

A. sedation

rationale: seizures can happen if you discontinue this med



PT is started on orlistat (Xenical, Alli). You identify that this medication

A. is a lipase inhibitor used to treat diabetes

B. is a lipase inhibitor used to treat obesity

C. is a lipase inhibitor used to increase muscle mass

D. is a lipase inhibitor used to lower cholesterol
- correct answer B. lipase inhibitor used to treat obesity

rationale: this is an anorexiant drug

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