NSC 330 Drugs affecting Autonomic Nervous System
Questions With Complete Solutions
What is another name for adrenergic antagonists?
adrenergic blockers
What is the MOA of adrenergic antagonists?
cause direct blockade of adrenergic receptors
What are 2 major groups of adrenergic antagonists?
alpha and beta adrenergic blocking agents, with selective and
non selective catagories in each
What are 3 examples of selective alpha-1 blockers/antagonists?
doxazosin, prazosin, terazosin
What is the MOA for alpha 1 blockers?
blocks alpha 1 receptors in vascular smooth muscles to
vasodilate arteries (lower peipheral vascular resistance) and in
bladder neck/prostate smooth muscle to relieve outflow
obstruction
What are the 2 uses of alpha 1 blockers?
hypertension, benign prostatic hypertrophy (BPH)
What are the 5 adverse effects of alpha 1 blockers?
orthostatic hypotension (1st dose effect, 30-90 min after first
dose) so give first dose at night, rebound tachycardia, nasal
, congestion, sodium/fluid retnetion, sexual dysfunction (inhibit
ejaculation)
What are 3 alpha-1 blockers nursing implications?
monitor VS, instruct client to change position slowly, first dose
effect education
What are 2 kinds of beta-adrenergic antagonists/beta-blockers?
cardioselective (beta 1), non cardioselective (beta 1/2)
What are 3 examples of cardioselective beta-adrenergic
antagonists?
metoprolol, atenolol, nebivolol
What are 3 examples of non cardioselective antagonist?
propranolol, labetolol, carvedilol
What are MOA of beta blockers?
blocks sympathetic (adrenergic) response by competing for beta
receptors, most therapeutic effects result from beta 1 blockage in
the heart
What are the 4 effects of beta blockers?
decrease HR, decrease contractility, decrease velocity of A-V
conduction, prevent renin release which will decrease sodium
and water
What are the 8 uses of beta blockers?
chronic HF, angina (reduce O2 demand), MI, htn,
tachyarrhythmias, migraine headaches (prevent vasodilation),
anxiety, glaucoma (decrease IOP)
Questions With Complete Solutions
What is another name for adrenergic antagonists?
adrenergic blockers
What is the MOA of adrenergic antagonists?
cause direct blockade of adrenergic receptors
What are 2 major groups of adrenergic antagonists?
alpha and beta adrenergic blocking agents, with selective and
non selective catagories in each
What are 3 examples of selective alpha-1 blockers/antagonists?
doxazosin, prazosin, terazosin
What is the MOA for alpha 1 blockers?
blocks alpha 1 receptors in vascular smooth muscles to
vasodilate arteries (lower peipheral vascular resistance) and in
bladder neck/prostate smooth muscle to relieve outflow
obstruction
What are the 2 uses of alpha 1 blockers?
hypertension, benign prostatic hypertrophy (BPH)
What are the 5 adverse effects of alpha 1 blockers?
orthostatic hypotension (1st dose effect, 30-90 min after first
dose) so give first dose at night, rebound tachycardia, nasal
, congestion, sodium/fluid retnetion, sexual dysfunction (inhibit
ejaculation)
What are 3 alpha-1 blockers nursing implications?
monitor VS, instruct client to change position slowly, first dose
effect education
What are 2 kinds of beta-adrenergic antagonists/beta-blockers?
cardioselective (beta 1), non cardioselective (beta 1/2)
What are 3 examples of cardioselective beta-adrenergic
antagonists?
metoprolol, atenolol, nebivolol
What are 3 examples of non cardioselective antagonist?
propranolol, labetolol, carvedilol
What are MOA of beta blockers?
blocks sympathetic (adrenergic) response by competing for beta
receptors, most therapeutic effects result from beta 1 blockage in
the heart
What are the 4 effects of beta blockers?
decrease HR, decrease contractility, decrease velocity of A-V
conduction, prevent renin release which will decrease sodium
and water
What are the 8 uses of beta blockers?
chronic HF, angina (reduce O2 demand), MI, htn,
tachyarrhythmias, migraine headaches (prevent vasodilation),
anxiety, glaucoma (decrease IOP)
