Berne & Levy Physiology 8th Edition Test Bank Koeppen | All Chapters Q&A | Latest 2025–2026 Updated

Berne and Levy Physiology 8th Edition
Koepp




Berne and Levy Physiology 8th Edition KoeppenTest Bank

KoeppenChapter 01: Principles of Cell Function Test Bank

Multiple Choice

1. The* * subcellular* * structure* * that* * degrades* * proteins* * is* * called* * the:

A. Tight* * junction
B. Mitochondria
C. Lysosome
D. Plasma* * membrane
E. Ribosome
ANS: C

2. An* * experiment* * is* * done* * to* * measure* * the* * uptake* * of* * an* * amino* * acid* * into* * a* *
cell.* * The* * foll**owing* * data* * are* * obtained:


N




If* * Na+* * is* * removed* * from* * the* * extracellular* * bathing* * solution,* * or* * if* * a* * drug* * is* * add
ed* * that* * preve**nts* * the* * cell* * from* * making* * adenosine* * triphosphate* * (ATP),* * the* * upta
ke* * of* * amino* * acid* * into* * th**e* * cell* * is* * markedly**reduced.* * According* * to* * this* * infor
mation,* * which* * of* * the* * followingmechan**isms* * is* * probably* * responsible* * for* * the* * tran
sport* * of* * the* * amino* * acid* * into* * the* * cell?

A. Passive* * diffusion* * through* * the* * lipid* * bilayer
B. Uniporter
C. Transport* * ATPase
D. Na+* * symporter
E. Na+**antiporter
ANS:* * * * D

3. A**membrane**permeable**by**only**Na+**separates**two**compartments**con
tain**ing* * Na2SO4,shown* * as* * follows:

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Electrodes* * are* * placed* * in* * both* * compartments,* * and* * a* * voltage* * is* * applied* * (that* * of*
* compartme**nt * * A* * is* * held* * at * * 0* * mV).* * What * * voltage* * applied* * to* * compartment * * B* *

would* * resultin* * no* * net* * mo**vement* * of* * Na+* * across* * the* * membrane* * separating* * the* *
compartments?

A. –60* * mV
B. –30* * mV
C. 0* * mV
D.
+30**m
V**E.
+60**m*
*V* * ANS:* * E




4. The**resting membrane**potentN
TV ial* * oRf* * a**Ic**e**l**lGis* * –
CV.* * The**intracellular**andU**extracellular
B85.m SN **concentrations* * of* * several* * ions* * are**

indicat**ed* * in* * the* * following* * table,* * as* * is* * the* * calculated
Nernst* * equilibrium* * potential* * (Ei)* * for* * each* * of* * these* * ions:

Ion Concentration Concentration Ei
Inside* * Cell Outside* * Cell
Na+ 12* * mEq/L 145* * mEq/L 66* * mV
K+ 150* * mEq/L 4* * mEq/L –96* * mV
Cl– 30* * mEq/L 105* * mEq/L –33* * mV
Ca++ 0.0001* * mmol/dL 1* * mmol/dL 122* * mV

The* * membrane* * has* * channels* * for* * Na+,* * K+,* * Cl–
,* * and* * Ca++.* * The* * conductance* * of* * the* * membrane* * is* * the* * greatest* * for* * which* * ion
?

A. Na+
B. K+
C. Cl–
D. Ca++
ANS:
B

5. A* * cell* * contains* * the* * following* * membrane* * transporters:

,Berne and Levy Physiology 8th Edition
Koepp
Na+**channelK+**channe
l* * Na+,K+-ATPase

The* * resting* * membrane* * voltage* * of* * the* * cell* * is* * –80* * mV,* * and* * the* * intracellular* * and
extracellular* * ion* * concentrations* * are* * as* * follows:

Ion Intracellular Extracellular
Concentration Concentration
Na+ 10* * mEq/L 145* * mEq/L
K+ 120* * mEq/L 4* * mEq/L

The* * cell* * is* * treated* * with* * a* * drug* * to* * inhibit* * the* * Na+,K+-
ATPase.* * What* * would* * be* * the* * effect* * ofthis* * drug* * on* * the* * following* * parameters?

Intracellular* * [Na+] Intracellular* * [K+] Cell* * Volume Membrane* * Voltage
A. Decrease Decrease Decrease Depolarize
B. Increase Decrease Increase Depolarize
C. Increase Increase Increase No* * change
D. Decrease Increase Decrease Hyperpolarize
E. Increase Increase Decrease Hyperpolarize

ANS: B

6. Which**of**the**labeled* * proteins**(shaded)**is**attached**to**the**memb
rane* * by**a* * glycosylphosphatidylinositol* * (GPI)* * anchor?




ANS: E


7.
A* * cell* * has* * channels* * for* * Na+,* * K+,* * and* * Cl–
in* * its* * plasma* * membrane.* * The* * resting* * membrane* * potential* * is* * –
60* * mV* * (cell* * interior* * negative).* * The* * intracellular* * and* * extracellular* * conce
ntrations** for* * these* * ions,* * as* * well* * as* * the* * calculated* * Nernst* * potentials,* * a
re* * listed* * as* * follows:

, Berne and Levy Physiology 8th Edition
Koepp




Ion Intracellular**Concentr Extracellular**Concentr Ei
ation ation
Na+ 14* * mEq/L 140* * mEq/L 60* * mV
K+ 150* * mEq/L 5* * mEq/L –89* * mV
Cl– 10* * mEq/L 100* * mEq/L –60* * mV

A* * drug* * is* * applied* * to* * the* * cell* * that* * increases* * the* * permeability* * of* * the* * cel
l* * by* * Cl– (i.e.,* * it**opens* * Cl–
channels).* * What* * effect* * will* * this* * drug* * have* * on* * the* * net* * movement
–
* * of* * Cl acrossthe* * plasma* * membrane?




A. Net* * Cl–* * movement* * out* * of* * the* * cell* * will* * be* * increased.
B. Net* * Cl–* * movement* * into* * the* * cell* * will* * be* * increased.
C. There* * will* * be* * no* * change* * in* * the* * net* * movement* * of* * Cl–.

ANS: C



8. Reducing**the**extracellular**[K+]**would**be**expected**to**have**which**of**the**f
ollo**wing**effects**on**the**resting** membrane**potential**and**on**the**excitability
**of**ve**ntricular* * myocytes?




Membrane* * Potential Excitability
A. Unchanged Unchanged
B. Hyperpolarized GDT
ecBre.aC
seO
d
C. Hyperpolarized Increased
D. Depolarized Decreased
E. Depolarized Increased

ANS: B


9. A* * cell* * is* * bathed* * in* * an* * isotonic* * NaCl* * solution* * that* * contains* * 5* * mmol/L*
* of* * glucose.**The* * intracellular* * concentration* * of* * glucose* * is* * 10* * mmol/L.* * W

hat* * is* * the**most* * likely** mechanism* * for* * the* * transport* * of* * glucose* * across* * th
e* * plasma* * membrane* * into* * this* * cel** l?

A. Glucose* * uniporter
B. Na+-glucose* * symporter
C. Na+-glucose* * antiporter
D. Diffusion**of**glucose**through**the**lipid**bilayer**of**the**me
mbr**ane* * ANS:* * B
10. A* * blood* * sample* * is* * taken* * from* * an* * individual* * whose* * blood* * osmolality* * is
* * 295* * mOs** m* * per* * kilogram* * of* * water.* * Red* * blood* * cells* * from* * this* * sam

ple* * are* * then* * placed* * in**the* * following* * solutions: