Update 2026
Entresto - - answerOften administered with other HF treatments
Used in place of ACEI or ARB
Side effects: ARNIs (HF) - - answerAngioedema
Hypotension
Hyperkalemia
Impaired renal function
Contraindications: ARNIs (HF) - - answerConcomitant use with ACEIs
Do not give within 36 hours of switching to or from ACEI
Heart failure medications: Aldosterone Receptor Antagonists/ Mineralcorticoid Receptor Antagonists
(ARA/MRA) - - answerSpironolactone (Aldactone)
Eplerenone (Inspra)
Mechanism of action: ARA/MRA - - answerEnhances action of thiazide + loop diuretics
Counteracts K+ loss from these medications
Used because ACEIs don't control aldosterone release
,Side effects: ARA/MRA - - answerHyperkalemia
Arrythmias
Amenorrhea
Gynecomastia
Deepening voice, increased hair growth
Muscle cramps
Agranulocytosis
Special considerations: ARA/MRA - - answerHepatic dysfunction
DM = increased risk of hyperkalemia
Contraindications: ARA/MRA - - answerAnuria
Acute renal insufficiency
Renal impairment (CrCL < 30ml/min in HF)
Hyperkalemia
Addison's disease (adrenal insufficiency-too little cortisol + aldosterone)
Concurrent use of eplerenone (inspra)
HCTZ negatively effects - - answerDyslipidemia and glucose control
High dose thiazide diuretics cause - - answerDecreased insulin resistance
ARA/MRA: Labs to monitor - - answerNa+, K+, Mg++ (looking for depletion)
ARA/MRA are ____ sparing and good for ____ - - answerCalcium; osteoporosis
ARA/MRA: less effective for ___ - - answerAdvancing renal impairment
CrCL < 30ml/min
, ARA/MRA: Effective for - - answerCombination with loop diuretics in patients with diuretic
resistance/edema that does not respond to loop monotherapy
Chronic stable angina: Treatment goals-prevention - - answerPrevention of MI + death =
Antiplatelet drugs
Cholesterol lowering drugs
ACEIs
Chronic stable angina: Treatment goals-symptoms - - answerReduction of cardiac ischemia + associated
pain =
Nitrates
beta-blockers
CCBs
Ranolazine
Chronic stable angina: Most expensive treatments - - answerCCBS, ACEIs
Chronic stable angina: Mid-range treatments - - answerBeta blockers
Chronic stable angina: Cheapest treatments - - answerNitrates
Angina assessment and monitoring - - answerAssess presence, characteristics and timing
Evaluate every 4-6 months during 1st year of therapy
Therapeutic action: Nitrates - - answerNitroglycerine
Acts directly on vascular smooth muscle to promote vasodilation
Therapeutic action: Beta blockers - - answerPropranolol, metoprolol
Decrease cardiac o2 demand through blockade of beta receptors in the heart