Names, ADME & FDA Regulations|Verified Questions
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Pharmacolgy
Study of drugs and their actions on living organisms
Generic drug name
Not capitalized
Nonproprietary
Official
Trade
Brand name
Capitalized
Chemical name
Gives exact chemical makeup
Not capitalized
FDA
Assigns generic name
Approves drug assigns category
1970 controlled substances act
Act regulates drugs with high abuse potential.
Nonprescription drugs
OTC
Take as directed
Drug development phases
Pre-FDA=test tube & live animals
Phase 1- healthy individuals
Phase 2-people who have the illness
Phase 3-more info dosing &safety
, Phase 4-on market with surveillance
Providers encouraged to report (IMSP) (MERP)
Pharmaceutic phase
Solid tab or cap dissolves
Disintegrates into small particles GI tract
Coated in small intestines.
Pharmacokinetics
Absorption distribution metabolism excretion
Absorption
Moving the drug from the site of administration into the bodily fluids and is the process by
which the drug is made available for the use in body. The drug particles in the G.I. tract are
moved into the body
First pass effect
The amount the liver metabolizes before releasing the drug into the body
Distribution
systematic circulation transports and distributes drugs to various body tissues or target
sites .Drug Binds to protein and travels through the body
Metabolism
Also known as biotransformation is the process by which the body changes a drug to a more or
less active form that can be excreted.
Where are drugs metabolized
Most drugs are metabolized by the liver although the kidneys lungs plasma and intestinal
mucosas also aid in the metabolism of drugs.
Metabolites
And in active form of the original drug
Excretion
The elimination of drugs from the body. After the liver renders drugs in active the kidneys
excrete the in active compounds from the body. other drugs are eliminated three sweat
breastmilk or breath or by the G.I. tract through feces