Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines evidence-based medicine as
described in Harrison’s?
A. Reliance on expert opinion
B. Integration of clinical expertise with best available evidence
C. Use of randomized trials only
D. Standardized protocols without patient input
Correct Answer: B
Rationale: Evidence-based medicine integrates clinician
expertise, patient values, and the best current evidence—not
evidence alone.
Citation: Harrison’s 22nd ed., Ch. 1 – The Practice of Medicine
,2. A nurse supporting health promotion should prioritize
which intervention with the strongest population-level
impact?
A. Genetic testing
B. Individual pharmacologic therapy
C. Lifestyle and behavioral modification
D. Advanced diagnostic screening
Correct Answer: C
Rationale: Harrison’s emphasizes lifestyle modification
(nutrition, activity, smoking cessation) as foundational to
promoting health.
Citation: Harrison’s 22nd ed., Ch. 2 – Promoting Good Health
3. Vaccine hesitancy is MOST commonly driven by which
factor?
A. Cost barriers alone
B. Lack of vaccine availability
C. Mistrust and misinformation
D. Prior adverse reactions only
Correct Answer: C
Rationale: Harrison’s identifies misinformation, distrust in
institutions, and perceived risks as primary drivers of vaccine
hesitancy.
,Citation: Harrison’s 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy
4. Which approach best improves shared clinical decision-
making?
A. Clinician-directed decisions
B. Algorithm-only recommendations
C. Incorporation of patient values and preferences
D. Limiting patient involvement
Correct Answer: C
Rationale: Shared decision-making requires aligning clinical
evidence with patient values and goals.
Citation: Harrison’s 22nd ed., Ch. 4 – Decision-Making in Clinical
Medicine
5. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Apply uniform treatments
C. Tailor care based on individual variability
D. Eliminate population-based guidelines
Correct Answer: C
Rationale: Precision medicine uses genetic, environmental, and
lifestyle factors to individualize care—not replace clinical
reasoning.
, Citation: Harrison’s 22nd ed., Ch. 5 – Precision Medicine and
Clinical Care
6. Which screening principle is emphasized to avoid patient
harm?
A. Screen all diseases early
B. Screening must improve meaningful outcomes
C. Screening should detect rare conditions
D. Screening replaces prevention
Correct Answer: B
Rationale: Harrison’s stresses that screening is justified only
when it improves morbidity or mortality.
Citation: Harrison’s 22nd ed., Ch. 6 – Screening and Prevention
of Disease
7. A key nursing implication for patient safety is:
A. Focusing on individual blame
B. Ignoring system-level errors
C. Promoting a culture of safety
D. Limiting error reporting
Correct Answer: C
Rationale: High-quality care depends on system-based
approaches and a non-punitive safety culture.
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines evidence-based medicine as
described in Harrison’s?
A. Reliance on expert opinion
B. Integration of clinical expertise with best available evidence
C. Use of randomized trials only
D. Standardized protocols without patient input
Correct Answer: B
Rationale: Evidence-based medicine integrates clinician
expertise, patient values, and the best current evidence—not
evidence alone.
Citation: Harrison’s 22nd ed., Ch. 1 – The Practice of Medicine
,2. A nurse supporting health promotion should prioritize
which intervention with the strongest population-level
impact?
A. Genetic testing
B. Individual pharmacologic therapy
C. Lifestyle and behavioral modification
D. Advanced diagnostic screening
Correct Answer: C
Rationale: Harrison’s emphasizes lifestyle modification
(nutrition, activity, smoking cessation) as foundational to
promoting health.
Citation: Harrison’s 22nd ed., Ch. 2 – Promoting Good Health
3. Vaccine hesitancy is MOST commonly driven by which
factor?
A. Cost barriers alone
B. Lack of vaccine availability
C. Mistrust and misinformation
D. Prior adverse reactions only
Correct Answer: C
Rationale: Harrison’s identifies misinformation, distrust in
institutions, and perceived risks as primary drivers of vaccine
hesitancy.
,Citation: Harrison’s 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy
4. Which approach best improves shared clinical decision-
making?
A. Clinician-directed decisions
B. Algorithm-only recommendations
C. Incorporation of patient values and preferences
D. Limiting patient involvement
Correct Answer: C
Rationale: Shared decision-making requires aligning clinical
evidence with patient values and goals.
Citation: Harrison’s 22nd ed., Ch. 4 – Decision-Making in Clinical
Medicine
5. Precision medicine primarily aims to:
A. Replace clinical judgment
B. Apply uniform treatments
C. Tailor care based on individual variability
D. Eliminate population-based guidelines
Correct Answer: C
Rationale: Precision medicine uses genetic, environmental, and
lifestyle factors to individualize care—not replace clinical
reasoning.
, Citation: Harrison’s 22nd ed., Ch. 5 – Precision Medicine and
Clinical Care
6. Which screening principle is emphasized to avoid patient
harm?
A. Screen all diseases early
B. Screening must improve meaningful outcomes
C. Screening should detect rare conditions
D. Screening replaces prevention
Correct Answer: B
Rationale: Harrison’s stresses that screening is justified only
when it improves morbidity or mortality.
Citation: Harrison’s 22nd ed., Ch. 6 – Screening and Prevention
of Disease
7. A key nursing implication for patient safety is:
A. Focusing on individual blame
B. Ignoring system-level errors
C. Promoting a culture of safety
D. Limiting error reporting
Correct Answer: C
Rationale: High-quality care depends on system-based
approaches and a non-punitive safety culture.
