Harrison's Principles of Internal Medicine
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines evidence-based medical
practice as described in The Practice of Medicine?
A. Reliance on expert opinion
B. Use of clinical intuition alone
C. Integration of best research evidence with clinical expertise
and patient values
D. Use of standardized protocols regardless of patient context
Correct Answer: C
Rationale: Harrison’s defines evidence-based medicine as
,combining high-quality evidence, clinician expertise, and
patient preferences to guide care decisions.
Citation: Harrison’s 22nd ed., Ch. 1 – The Practice of Medicine
2. Which intervention has the greatest population-level impact
on promoting good health?
A. Advanced imaging availability
B. Individual pharmacologic therapy
C. Addressing social determinants of health
D. Expansion of specialty care
Correct Answer: C
Rationale: Harrison’s emphasizes that social, economic, and
environmental factors exert the strongest influence on
population health outcomes.
Citation: Harrison’s 22nd ed., Ch. 2 – Promoting Good Health
3. A major driver of vaccine hesitancy identified in Harrison’s
is:
A. Vaccine cost
B. Scientific uncertainty
C. Mistrust of health institutions
D. Lack of vaccine supply
Correct Answer: C
Rationale: Mistrust—often rooted in misinformation, cultural
,beliefs, or historical injustices—is a key contributor to vaccine
opposition.
Citation: Harrison’s 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy
4. Shared decision-making is most appropriate when:
A. Only one treatment option exists
B. Benefits clearly outweigh risks
C. Multiple reasonable options with trade-offs exist
D. The patient lacks decisional capacity
Correct Answer: C
Rationale: Harrison’s highlights shared decision-making when
clinical choices involve value-sensitive trade-offs.
Citation: Harrison’s 22nd ed., Ch. 4 – Decision-Making in Clinical
Medicine
5. Precision medicine primarily aims to:
A. Replace population-based guidelines
B. Eliminate clinical judgment
C. Tailor care using genetic, environmental, and lifestyle data
D. Focus only on rare diseases
Correct Answer: C
Rationale: Precision medicine individualizes prevention and
treatment strategies using biologic and contextual patient data.
, Citation: Harrison’s 22nd ed., Ch. 5 – Precision Medicine and
Clinical Care
6. Which criterion is MOST important when selecting a
screening test?
A. Cost of the test
B. Disease prevalence and test accuracy
C. Patient age alone
D. Availability of advanced treatment
Correct Answer: B
Rationale: Effective screening requires sufficient disease
prevalence and acceptable sensitivity/specificity to reduce
harm.
Citation: Harrison’s 22nd ed., Ch. 6 – Screening and Prevention
of Disease
7. A key nursing implication of screening programs is to:
A. Screen all patients regardless of risk
B. Ensure informed consent and patient understanding
C. Focus only on test performance
D. Avoid discussing false positives
Correct Answer: B
Rationale: Harrison’s stresses informed participation and
understanding of benefits and harms in preventive care.
(Vol.1 & Vol.2)
22nd Edition
• Author(s)Joseph Loscalzo; Anthony S.
Fauci; Dennis L. Kasper; Stephen Hauser;
Dan Longo; J. Larry Jameson
Test Bank
1. Which principle best defines evidence-based medical
practice as described in The Practice of Medicine?
A. Reliance on expert opinion
B. Use of clinical intuition alone
C. Integration of best research evidence with clinical expertise
and patient values
D. Use of standardized protocols regardless of patient context
Correct Answer: C
Rationale: Harrison’s defines evidence-based medicine as
,combining high-quality evidence, clinician expertise, and
patient preferences to guide care decisions.
Citation: Harrison’s 22nd ed., Ch. 1 – The Practice of Medicine
2. Which intervention has the greatest population-level impact
on promoting good health?
A. Advanced imaging availability
B. Individual pharmacologic therapy
C. Addressing social determinants of health
D. Expansion of specialty care
Correct Answer: C
Rationale: Harrison’s emphasizes that social, economic, and
environmental factors exert the strongest influence on
population health outcomes.
Citation: Harrison’s 22nd ed., Ch. 2 – Promoting Good Health
3. A major driver of vaccine hesitancy identified in Harrison’s
is:
A. Vaccine cost
B. Scientific uncertainty
C. Mistrust of health institutions
D. Lack of vaccine supply
Correct Answer: C
Rationale: Mistrust—often rooted in misinformation, cultural
,beliefs, or historical injustices—is a key contributor to vaccine
opposition.
Citation: Harrison’s 22nd ed., Ch. 3 – Vaccine Opposition and
Hesitancy
4. Shared decision-making is most appropriate when:
A. Only one treatment option exists
B. Benefits clearly outweigh risks
C. Multiple reasonable options with trade-offs exist
D. The patient lacks decisional capacity
Correct Answer: C
Rationale: Harrison’s highlights shared decision-making when
clinical choices involve value-sensitive trade-offs.
Citation: Harrison’s 22nd ed., Ch. 4 – Decision-Making in Clinical
Medicine
5. Precision medicine primarily aims to:
A. Replace population-based guidelines
B. Eliminate clinical judgment
C. Tailor care using genetic, environmental, and lifestyle data
D. Focus only on rare diseases
Correct Answer: C
Rationale: Precision medicine individualizes prevention and
treatment strategies using biologic and contextual patient data.
, Citation: Harrison’s 22nd ed., Ch. 5 – Precision Medicine and
Clinical Care
6. Which criterion is MOST important when selecting a
screening test?
A. Cost of the test
B. Disease prevalence and test accuracy
C. Patient age alone
D. Availability of advanced treatment
Correct Answer: B
Rationale: Effective screening requires sufficient disease
prevalence and acceptable sensitivity/specificity to reduce
harm.
Citation: Harrison’s 22nd ed., Ch. 6 – Screening and Prevention
of Disease
7. A key nursing implication of screening programs is to:
A. Screen all patients regardless of risk
B. Ensure informed consent and patient understanding
C. Focus only on test performance
D. Avoid discussing false positives
Correct Answer: B
Rationale: Harrison’s stresses informed participation and
understanding of benefits and harms in preventive care.
