Nurs 5334-Advanced Pharm-Test 1
v7 v7 v7
Pregnancy:v7Changesv7inv7drugv7metabolismv7-v7correctv7answer✔ ✔ -
Hepaticv7metabolismv7andv7GFRv7increasev7duringv7pregnancy,v7dosagesv7ofv
7somev7drugsv7mayv7needv7tov7bev7increasedv7
-Forv7somev7drugs,v7hepaticv7metabolismv7increasesv7duringv7pregnancy--
>v7somev7drugsv7mayv7needv7tov7bev7increased
-
Tonev7andv7motilityv7ofv7thev7bowelv7decreasev7inv7pregnancy,v7causingv7intes
tinalv7transitv7timev7tov7increase
-->morev7timev7forv7drugsv7tov7bev7absorbed--
>v7mightv7needv7tov7reducev7dosage
-Prolongationv7ofv7drugv7effectsv7totalv71-2v7lifev7increases
Fetalv7developmentv7inv7pregnancyv7(stages)v7-v7correctv7answer✔ ✔ -
preimplantation/presomite:v7conception-2v7weeks:v7allv7orv7nothingv7
-embryonicv7period:v7weeksv73-8:v7grossv7malformations
-Fetalv7period:v7weekv79-
v7term:v7exposurev7disruptsv7functionv7notv7grossv7anatomy
Pregnancyv7Labelingv7-v7correctv7answer✔ ✔ -
Asv7ofv72015,v7thev7Foodv7andv7Drugv7Administrationv7hadv7av7Pregnancyv7an
dv7Lactationv7Labelingv7Rulev7change.
,-
Nov7morev7letteringv7ofv7thev7categoriesv7ofv7drugsv7forv7pregnancy.v7Accordi
ngv7tov7thev7letteringv7system,v7drugsv7canv7bev7putv7intov7onev7ofv7fivev7riskv7ca
tegories:v7bev7A,v7B,v7C,v7D,v7andv7X.
-Byv72020,v7allv7prescriptionsv7mustv7removev7letteringv7labelsv7altogether.
-Thev7PLLRv7requiresv7threev7sectionsv7forv7labeling:
ov7(1)v7pregnancy,v7(2)v7lactation,v7andv7(3)v7femalesv7andv7malesv7ofv7reprodu
ctivev7potential.
Howv7dov7youv7decreasev7riskv7inv7thev7infantv7duringv7breastfeeding?v7-
v7correctv7answer✔ ✔
ov7Takev7thev7drugsv7immediatelyv7afterv7breastfeeding
ov7Avoidv7drugsv7thatv7havev7longv7half-lives
ov7Choosev7drugsv7thatv7tendv7tov7bev7excludedv7fromv7milk,v7andv7thatv7arev7le
astv7likelyv7tov7affectv7thev7infant
ov7Avoidv7thev7drugsv7thatv7arev7knownv7tov7bev7hazardous
ov7Usev7thev7lowestv7effectivev7dosagev7forv7thev7shortestv7possiblev7time
ov7Abandonv7plansv7tov7breastfeedv7ifv7av7necessaryv7drugv7isv7knownv7tov7bev7h
armfulv7tov7thev7child.
Howv7dov7pediatricv7patientsv7differv7inv7theirv7responsev7tov7medication?v7Ab
sorption?v7-v7correctv7answer✔ ✔ ov7Oralv7administration
-Gastricv7emptyingv7timev7isv7prolongedv7&v7irregularv7inv7earlyv7infancy
,·v7Adultv7functionv7atv75-8v7months
·v7Forv7drugsv7thatv7arev7absorbedv7primarilyv7fromv7thev7stomach,v7delayedv7g
astricv7emptyingv7enhancesv7absorption
·v7Forv7drugsv7thatv7arev7absorbedv7primarilyv7fromv7thev7intestine,v7absorptio
nv7isv7delayed
·v7Becausev7gastricv7emptyingv7timev7isv7irregular,v7thev7precisev7effectv7onv7a
bsorptionv7isv7notv7predictable
-v7Gastricv7Acidity
·v7Veryv7lowv724v7hoursv7afterv7birth
·v7Doesv7notv7reachv7adultv7valuesv7forv72v7years
·v7Lowv7acidityv7absorptionv7ofv7acid-labilev7drugsv7isv7increased
ov7Intramuscular
-Slow,v7erraticv7inv7neonates
-
Delayedv7absorptionv7asv7av7resultv7ofv7lowv7bloodv7flowv7duringv7thev7firstv7f
v7
ewv7daysv7ofv7life
-
Byv7earlyv7infancy,v7absorptionv7ofv7IMv7drugsv7isv7morev7rapidv7thanv7inv7ne
v7
onatesv7andv7adults
ov7Skin
-
Morev7rapidv7andv7completev7inv7infantsv7thanv7inv7olderv7childrenv7andv7adul
v7
ts
, -
v7Thev7stratumv7corneumv7ofv7thev7infant'sv7skinv7isv7veryv7thin,v7andv7bloodv7fl
owv7tov7thev7skinv7isv7greaterv7inv7infantsv7thanv7inv7olderv7patients.v7Becausev7
ofv7thisv7enhancedv7absorption,v7infantsv7arev7atv7increasedv7riskv7forv7toxicity
v7fromv7topicalv7drugs.
Howv7dov7pediatricv7patientsv7differv7inv7theirv7responsev7tov7medication?v7Di
stributionv7r/tv7proteinv7binding?v7-v7correctv7answer✔ ✔ -
Bindingv7ofv7drugsv7tov7albuminv7andv7otherv7plasmav7proteinsv7isv7limitedv7inv
7thev7infant
-v7Amountv7ofv7serumv7albuminv7isv7relativelyv7low
-
Endogenousv7compoundsv7(fattyv7acids,v7bilirubin)v7competev7withv7drugsv7
v7
forv7availablev7bindingv7sites
-v7Limitedv7drug/proteinv7bindingv7inv7infantsv7--
>v7concentrationv7ofv7freev7levelsv7ofv7drugsv7thatv7usuallyv7undergov7extensiv
ev7proteinv7bindingv7inv7adultsv7isv7relativelyv7highv7inv7thev7infantv7--
>v7intensifiedv7effects
-v7Reducedv7dosagev7needed
-v7Adultv7proteinv7bindingv7capacityv7byv710-12v7monthsv7ofv7age
Howv7dov7pediatricv7patientsv7differv7inv7theirv7responsev7tov7medication?v7Di
stributionv7r/tv7BBB?v7-v7correctv7answer✔ ✔ -
v7Notv7fullyv7developedv7atv7birth
-v7Drugsv7andv7otherv7chemicalsv7havev7relativelyv7easyv7accessv7tov7thev7CNS
v7 v7 v7
Pregnancy:v7Changesv7inv7drugv7metabolismv7-v7correctv7answer✔ ✔ -
Hepaticv7metabolismv7andv7GFRv7increasev7duringv7pregnancy,v7dosagesv7ofv
7somev7drugsv7mayv7needv7tov7bev7increasedv7
-Forv7somev7drugs,v7hepaticv7metabolismv7increasesv7duringv7pregnancy--
>v7somev7drugsv7mayv7needv7tov7bev7increased
-
Tonev7andv7motilityv7ofv7thev7bowelv7decreasev7inv7pregnancy,v7causingv7intes
tinalv7transitv7timev7tov7increase
-->morev7timev7forv7drugsv7tov7bev7absorbed--
>v7mightv7needv7tov7reducev7dosage
-Prolongationv7ofv7drugv7effectsv7totalv71-2v7lifev7increases
Fetalv7developmentv7inv7pregnancyv7(stages)v7-v7correctv7answer✔ ✔ -
preimplantation/presomite:v7conception-2v7weeks:v7allv7orv7nothingv7
-embryonicv7period:v7weeksv73-8:v7grossv7malformations
-Fetalv7period:v7weekv79-
v7term:v7exposurev7disruptsv7functionv7notv7grossv7anatomy
Pregnancyv7Labelingv7-v7correctv7answer✔ ✔ -
Asv7ofv72015,v7thev7Foodv7andv7Drugv7Administrationv7hadv7av7Pregnancyv7an
dv7Lactationv7Labelingv7Rulev7change.
,-
Nov7morev7letteringv7ofv7thev7categoriesv7ofv7drugsv7forv7pregnancy.v7Accordi
ngv7tov7thev7letteringv7system,v7drugsv7canv7bev7putv7intov7onev7ofv7fivev7riskv7ca
tegories:v7bev7A,v7B,v7C,v7D,v7andv7X.
-Byv72020,v7allv7prescriptionsv7mustv7removev7letteringv7labelsv7altogether.
-Thev7PLLRv7requiresv7threev7sectionsv7forv7labeling:
ov7(1)v7pregnancy,v7(2)v7lactation,v7andv7(3)v7femalesv7andv7malesv7ofv7reprodu
ctivev7potential.
Howv7dov7youv7decreasev7riskv7inv7thev7infantv7duringv7breastfeeding?v7-
v7correctv7answer✔ ✔
ov7Takev7thev7drugsv7immediatelyv7afterv7breastfeeding
ov7Avoidv7drugsv7thatv7havev7longv7half-lives
ov7Choosev7drugsv7thatv7tendv7tov7bev7excludedv7fromv7milk,v7andv7thatv7arev7le
astv7likelyv7tov7affectv7thev7infant
ov7Avoidv7thev7drugsv7thatv7arev7knownv7tov7bev7hazardous
ov7Usev7thev7lowestv7effectivev7dosagev7forv7thev7shortestv7possiblev7time
ov7Abandonv7plansv7tov7breastfeedv7ifv7av7necessaryv7drugv7isv7knownv7tov7bev7h
armfulv7tov7thev7child.
Howv7dov7pediatricv7patientsv7differv7inv7theirv7responsev7tov7medication?v7Ab
sorption?v7-v7correctv7answer✔ ✔ ov7Oralv7administration
-Gastricv7emptyingv7timev7isv7prolongedv7&v7irregularv7inv7earlyv7infancy
,·v7Adultv7functionv7atv75-8v7months
·v7Forv7drugsv7thatv7arev7absorbedv7primarilyv7fromv7thev7stomach,v7delayedv7g
astricv7emptyingv7enhancesv7absorption
·v7Forv7drugsv7thatv7arev7absorbedv7primarilyv7fromv7thev7intestine,v7absorptio
nv7isv7delayed
·v7Becausev7gastricv7emptyingv7timev7isv7irregular,v7thev7precisev7effectv7onv7a
bsorptionv7isv7notv7predictable
-v7Gastricv7Acidity
·v7Veryv7lowv724v7hoursv7afterv7birth
·v7Doesv7notv7reachv7adultv7valuesv7forv72v7years
·v7Lowv7acidityv7absorptionv7ofv7acid-labilev7drugsv7isv7increased
ov7Intramuscular
-Slow,v7erraticv7inv7neonates
-
Delayedv7absorptionv7asv7av7resultv7ofv7lowv7bloodv7flowv7duringv7thev7firstv7f
v7
ewv7daysv7ofv7life
-
Byv7earlyv7infancy,v7absorptionv7ofv7IMv7drugsv7isv7morev7rapidv7thanv7inv7ne
v7
onatesv7andv7adults
ov7Skin
-
Morev7rapidv7andv7completev7inv7infantsv7thanv7inv7olderv7childrenv7andv7adul
v7
ts
, -
v7Thev7stratumv7corneumv7ofv7thev7infant'sv7skinv7isv7veryv7thin,v7andv7bloodv7fl
owv7tov7thev7skinv7isv7greaterv7inv7infantsv7thanv7inv7olderv7patients.v7Becausev7
ofv7thisv7enhancedv7absorption,v7infantsv7arev7atv7increasedv7riskv7forv7toxicity
v7fromv7topicalv7drugs.
Howv7dov7pediatricv7patientsv7differv7inv7theirv7responsev7tov7medication?v7Di
stributionv7r/tv7proteinv7binding?v7-v7correctv7answer✔ ✔ -
Bindingv7ofv7drugsv7tov7albuminv7andv7otherv7plasmav7proteinsv7isv7limitedv7inv
7thev7infant
-v7Amountv7ofv7serumv7albuminv7isv7relativelyv7low
-
Endogenousv7compoundsv7(fattyv7acids,v7bilirubin)v7competev7withv7drugsv7
v7
forv7availablev7bindingv7sites
-v7Limitedv7drug/proteinv7bindingv7inv7infantsv7--
>v7concentrationv7ofv7freev7levelsv7ofv7drugsv7thatv7usuallyv7undergov7extensiv
ev7proteinv7bindingv7inv7adultsv7isv7relativelyv7highv7inv7thev7infantv7--
>v7intensifiedv7effects
-v7Reducedv7dosagev7needed
-v7Adultv7proteinv7bindingv7capacityv7byv710-12v7monthsv7ofv7age
Howv7dov7pediatricv7patientsv7differv7inv7theirv7responsev7tov7medication?v7Di
stributionv7r/tv7BBB?v7-v7correctv7answer✔ ✔ -
v7Notv7fullyv7developedv7atv7birth
-v7Drugsv7andv7otherv7chemicalsv7havev7relativelyv7easyv7accessv7tov7thev7CNS
