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NUR 376 – Pathophysiology Exam 3 (100 Q&As) | Neuro, Stroke, ICP, Pain, MS, RA, OA, ALS | Concordia College St. Paul

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This expertly structured study guide for NUR 376 – Nursing Pathophysiology provides 100 high-yield questions and answers tailored for Exam 3 (2026) at Concordia College St. Paul. It is designed to support nursing and allied health students in mastering critical neurological, musculoskeletal, and stress response topics, with detailed explanations aligned with real-world clinical scenarios. Key topics include: Intracranial Pressure (ICP): Causes, symptoms, Cushing’s triad, Monroe-Kellie hypothesis, interventions to manage increased ICP. Cerebrovascular Events (Stroke): Ischemic, hemorrhagic, and TIA pathophysiology, clinical signs, FAST acronym, nursing priorities, and golden hour management. Neurological Disorders: Seizures (types, stages, care), Parkinson’s Disease, Alzheimer’s Disease, ALS (Amyotrophic Lateral Sclerosis), and Multiple Sclerosis. Stress and Coping: Seyle’s, Cannon’s, and McEwen’s stress response theories, chronic stress impact, and adaptive/maladaptive mechanisms. Pain Management: Nociception, gate control theory, acute vs. chronic vs. neuropathic pain, pharmacologic and non-pharmacologic approaches. Musculoskeletal Trauma: Sprains, fractures (types and care), neurovascular injury, osteoporosis, osteoarthritis (OA), rheumatoid arthritis (RA), and osteomyelitis. Gout and Lyme Disease: Pathophysiology, clinical signs, diagnostic clues, and treatment essentials. Suitable for: Undergraduate nursing students in courses such as Pathophysiology, Medical-Surgical Nursing, Neurological Nursing, or Advanced Health Assessment. Allied health students preparing for exams or seeking supplemental material for clinical training. Candidates preparing for NCLEX-RN or similar licensing and board exams. This document offers a high-impact review of critical pathophysiology concepts with easy-to-understand rationales that reinforce clinical reasoning and academic success. Keywords: NUR 376, exam 3, pathophysiology, ICP, stroke, seizures, Parkinson's, Alzheimer's, ALS, MS, RA, OA, osteoporosis, fractures, pain management, stress response, nursing, NCLEX prep, Concordia College St. Paul

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NUR 376 EXAM 3 2026 EXAM
QUESTIONS AND ANSWERS | 100%
PASS



ICP - 🧠 ANSWER ✔✔intracranial pressure = balance of pressure of the

brain tissue, blood, and CSF.

(normal pressure is 5 to 15 mm Hg)


Changes to ICP - 🧠 ANSWER ✔✔brain tissue, cerebral blood flow

(hypertension), or CSF


Monroe-Kellie hypothesis* - 🧠 ANSWER ✔✔increase in one compartment

of the brain is compensated by a decrease in the other compartments of

the brain

,Increased ICP patho - 🧠 ANSWER ✔✔initially compressing blood vessels in

the brian = less blood = less O2 = cerebral hypoxia




If ICP continues to increase and cause more pressure on the brain stem,

Cushing's triad- hypertension with wide pulse pressure, low HR

(bradycardia), and low RR (bradypnea)

early clinical manifestations pt suspected increased ICP* - 🧠 ANSWER

✔✔reduced LOC (irritability or restlessness), decreased mental status*-

earliest sign, sleepiness, flat affect & drowsiness


moderate signs pt suspected increased ICP - 🧠 ANSWER ✔✔headache-

constant (patho: stretching of meninges), sudden vomiting "emisis) without

nausea!- report (patho- pressure on medulla)

late- clinical manifestations pt suspected increased ICP* - 🧠 ANSWER

✔✔Brain stem affected: extra pressure on the brian, eventually squashing

the brian stem which controls breathing & heart = kills pt

Eyes: pupils fixed & dilated (8 mm, normal 2-6mm) , sometimes unequal-

pressure on cranial nerve 3 (oculomotor nerve)

,We want dolls eyes- meaning the eyes move in opposite direct of head

movement = brain stem is in tact!!

Papilledema- swelling around the optic disk caused by increased pressure

of CSF

lungs: irregular respirations, cheyne stroke respirations (apnea)

Neck: nuchal rigidity (stiff neck)- can not FLEX chin towards chest




crushing triad


Cushing's triad - 🧠 ANSWER ✔✔hypertension with wide pulse pressure,

slowed heart rate (bradycardia), and slowed respirations (bradypnea)


Intracranial hypertension* - 🧠 ANSWER ✔✔increased ICP)- Mechanisms

that increase the volume of one or more of three compartments—

circulation, brain tissue, and CSF—will increase ICP


Mechanisms that decrease ICP* - 🧠 ANSWER ✔✔decreasing volume of

any one of the three compartments- brain tissue, CSF, or circulation- will

decrease the ICP

Causes:


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, -Externally draining CSF via a catheter placed in the ventricles will lower

ICP.

-Blood volume can also be reduced by lowering blood pressure

-Infusing a hypertonic solution such as IV mannitol can rapidly decrease

intracellular pressure and lower cerebral edema.

-A low carbon dioxide level will vasoconstrict cerebral arteries, reducing the

volume of blood delivered to the brain.

-Removing brain tissue, such as occurs in a lobectomy, will likewise

decrease volume and ICP.

decompressive craniectomy, in which a section of the skull is removed,

creating an opening in the closed space of the skull and allowing expansion

of the brain.

-This allows the ICP to increase without the danger of compressing brain

tissue


what is a stroke? - 🧠 ANSWER ✔✔inability of O2 rich blood to reach the

brain due to blockage or bleeding in a vessel


Types of stroke - 🧠 ANSWER ✔✔ischemic, transient ischemic, and

hemorrhagic

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