,https://www.stuvia.com/
Chapternj1njRBCsnjandnjPlateletnjPreservation:njHistoricalnjPerspectivesnjandnjCurrentnjTrends
MultiplenjChoice
Identifynjthenjchoicenjthatnjbestnjcompletesnjthenjstatementnjornjanswersnjthenjquestion.
1. Whichnjmetabolicnjpathwaynjisnjresponsiblenjfornjgeneratingnj90%njofnjthenjATPnjfornjthenjRBC?
a. Pentosenjphosphatenjshunt c. Glycolysis
b. Luebering-Rapoportnjshunt d.n j Methemoglobinnjreductase
2. Anjunitnjofnjbloodnjwasnjreturnednjtonjthenjbloodnjbanknjbeforenjitnjwasnjspiked.njApparentlynjthenjpatient’snjIVnjfaile
d.njThenjunitnjofnjbloodnjwasnjoutsidenjthenjbloodnjbanknjfornj35njminutes.njWhichnjofnjthenjstatementsnjbelownjisnj
mostnjaccurate?
a. Thenjunitnjofnjbloodnjshouldnjbenjdiscardednjimmediately.
b. Thenjunitnjofnjbloodnjcannjbenjreturnednjtonjinventory.
c. Thenjunitnjofnjbloodnjmustnjbenjtransfusednjwithinnj4njhoursnjornjbenjdiscardednjatnjthenjendnjofnjthatnjtime.
d. Thenjunitnjofnjbloodnjmustnjbenjtransfusednjwithnj24njhours.
3. Whatnjisnjthenjaveragenjdiameternjofnjanjplatelet?
a. 5njtonj10njµm c. 1njtonj2njµm
b. 2njtonj4njµm d.n j n j 4njtonj6njµm
4. Innjthenjnormalnjhemoglobin-
oxygennjdissociationnjcurve,njwhatnjpercentagenjofnjoxygennjisnjreleasednjtonjthenjtissuesnjwhennjPO2n j average
snj40njmmnjHg?
a. 75% c. 100%
b. 25% d.n j 50%
5. Whatnjfactorsnjarenjknownnjtonjinfluencenjplateletnjmetabolismnjandnjfunction?
a. Storagenjtemperature c. Plateletnjcount
b. InitialnjpH d.n j Allnjofnjthenjabove
6. Whichnjofnjthenjfollowingnjrednjbloodnjcellnjmorphologiesnjmaynjbenjpresentnjonnjthenjperipheralnjbloodnjsmearnjasnj
anjresultnjofnjlossnjofnjRBCnjmembrane?
a. Spherocytes c. Burrnjcells
b. Targetnjcells d.n j Schistocytes
7. Whatnjdoesnjthenjtermnjautologousnjtransfusionnjrefernjto?
a. Anjparentnjdonatingnjbloodnjfornjhisnjornjhernjchild
b. Annjindividualnjdonatingnjbloodnjfornjanjfriend
c. Annjindividualnjdonatingnjbloodnjfornjanjrelative
d. Annjindividualnjdonatingnjbloodnjfornjhisnjornjhernjownnjtransfusion
8. Whatnjisnjthenjprimarynjfunctionnjofnjhemoglobin?
a. Ironnjmetabolism c. Oxygennjtransport
b. Porphyrinnjsynthesis d.n j Signalnjtransduction
9. Allnjofnjthenjfollowingnjareasnjofnjrednjbloodnjcellnjbiologynjarenjcrucialnjfornjnormalnjerythrocytenjsurvivalnjexcept:
a. Cellularnjmetabolism. c. SitenjofnjthenjABOnjantigennjattachment.
b. RBCnjmembrane. d.n j Hemoglobinnjstructure.
Thisnjstudynjsourcenjwasnjdownloadednjbynj100000826342158njfromnjCourseHero.comnjonnj09-15-
2021nj17:54:15njGMTnj-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
nj 10.n j WhatnjisnjthenjcorrectnjbiochemicalnjcompositionnjofnjthenjRBCnjmembrane?
a. 52%njprotein,nj40%njlipid,nj8%njcarbohydrate
b. 40%njprotein,nj8%njlipid,nj52%njcarbohydrate
c. 8%njprotein,nj52%njlipid,nj40%njcarbohydrate
d. 8%njlipid,nj40%njcarbohydrate,nj52%njprotein
nj 11.n j Allnjofnjthenjfollowingnjbiochemicalnjchangesnjarenjassociatednjwithnjlossnjofnjrednjbloodnjcellnjviabilitynjuponnjstora
ge
except:
a. DecreasednjpH. c. IncreasednjATPnjlevel.
b. Lossnjofnjrednjbloodnjcellnjfunction. d.n j Decreasednjglucosenjconsumption.
nj 12.n j Whichnjrednjbloodnjcellnjpreservativenjhasnjanjstoragenjtimenjofnj35njdays?
a. ACD c. AS-1
b. CPDA-1 d.n j n j CPD
nj 13.n j ThenjRBCnjmembranenjisnjrelativelynjpermeablenjtonjallnjofnjthenjfollowingnjexcept:
a. Chloride. c. Bicarbonate.
b. Sodium. d.n j Water.
nj 14.njWhatnjpercentagenjofnjplateletsnjisnjsequesterednjinnjthenjspleennjasnjfunctionalnjreservenjafternjbeingnjreleasednjfr
omnjthenjbonenjmarrow?
a. 30% c. 10%
b. 50% d.n j n j 25%
nj 15.n j Whatnjisnjthenjmajornjbiochemicalnjconsiderationnjinnjplateletnjstorage?
a. Glucosenjmetabolism c. Productionnjofnjcarbonnjdioxide
b. Oxygennjsupply d.n j RegulationnjofnjpH
nj 16.njWhatnjwouldnjthenjhemoglobin-
oxygennjdissociationnjcurvenjdepictnjinnjanjpatientnjexhibitingnjclinicalnjsignsnjofnjalkalosis?
a. Normal c. Shiftnjtonjthenjright
b. Shiftnjtonjthenjleft d.n j Nonenjofnjthenjabove
nj 17.n j Namenjthenjmainnjlipidnjcomponentsnjofnjanjrednjbloodnjcellnjmembrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d.n j GlycophorinnjA
nj 18.n j ThenjABOnjbloodnjgroupsnjwerenjdiscoverednjinnj1901njbynjwhom?
a. CharlesnjDrew c. LoutitnjandnjMollison
b. KarlnjLandsteiner d.n j EdwardnjLindeman
nj 19.njAnjstandingnjordernjofnjplateletsnjwasnjshippednjtonjyournjfacilitynjbynjyournjsupplier.njItnjwasnjinadvertentlynjleftnj
innjthenjcornernjofnjthenjdepartmentnjuntilnjdiscoverednj36njhoursnjlater.njWhatnjwouldnjthenjappropriatenjactionnjbenj
fornjthenjbloodnjbanker?
a. Ifnjthenjtemperaturenjinnjthenjboxnjwasnj22nj+/-
nj2°CnjandnjthenjplateletnjswirlnjseemednjOK,njitnjwouldnjbenjOKnjtonjacceptnjthenjunitnjintonjinven
tory.
b. Thenjplateletsnjhavenjfallennjoutsidenjthenjsupplier’snjqualitynjassurance.njThenjunitnjshouldnj
benjdiscardednjbecausenjthenjpHnjhasnjprobablynjdroppednjtoonjlownjandnjplateletnjactivationnj
hasnjbeennjcompromised.
c. Ifnjthenjtemperaturenjwasnj1°Cnjtonj6°CnjandnjthenjplateletnjswirlnjseemednjOK,njitnjwouldnjbenjOKnjto
Thisnjstudynjsourcenjwasnjdownloadednjbynj100000826342158njfromnjCourseHero.comnjonnj09-15-
2021nj17:54:15njGMTnj-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
acceptnjthenjunitnjintonjinventory.
d. IfnjthenjplateletsnjappearednjOKnjandnjpassednjthenjplateletnjswirlnjtestnjafternjbeingnjplacednj
onnjthenjagitator,njtheynjcouldnjbenjacceptednjintonjthenjinventory.
nj 20.n j Whichnjmetabolicnjpathwaynjpermitsnjthenjaccumulationnjofnj2,3njdiphosphoglyceratenj(2,3-DPG)?
a. Glycolysis c. Pentosenjphosphatenjshunt
b. Luebering-Rapoportnjshunt d.n j Methemoglobinnjreductase
n j 21.n j Allnjofnjthenjfollowingnjarenjconsistentnjwithnjanj"shiftnjtonjthenjright"njofnjthenjhemoglobin-
oxygennjdissociationnjcurve
except:
a. Increasednj2,3-DPG.
b. 50%njO2n j saturationnjtonjtissues.
c. Decreasednj2,3-DPG.
d. DecreasednjhemoglobinnjaffinitynjfornjO2.
nj 22.n j Whatnjisnjthenjnormalnjplateletnjcountnjrangenjpernjcubicnjmillimeter?
a. 100njtonj350 c. 50,000njtonj200,000
b. 150,000njtonj350,000 d.n j 350,000njtonj500,000
nj 23.n j Whatnjcryoprotectivenjagentnjisnjaddednjtonjrednjbloodnjcellsnjuponnjfreezing?
a. Dextrose c. Glycerol
b. Adsol d.n j Allnjofnjthenjabove
nj 24.n j Ifnjplateletsnjarenjtonjbenjstorednjfornj5njdaysnjonnjanjrotator,njwhatnjisnjthenjoptimalnjstoragenjtemperature?
a. 1°Cnjtonj6°C c. 35°Cnjtonj37°C
b. 20°Cnjtonj24°C d.n j 1°Cnjtonj10°C
nj 25.n j Whatnjrolenjdonjplateletsnjplaynjinnjhemostasis?
a. Maintenancenjofnjvascularnjintegrity
b. Initialnjarrestnjofnjbleedingnjbynjplateletnjplugnjformation
c. Stabilizationnjofnjthenjhemostaticnjplug
d. Allnjofnjthenjabove
nj 26.n j Whichnjofnjthenjfollowingnjbestnjdescribesnj"integral"njmembranenjproteins?
a. Residenjatnjthenjcytoplasmicnjsurfacenjofnjmembrane
b. Spannjthenjentirenjmembranenjsurface
c. Formnjthenjrednjbloodnjcellnjcytoskeleton
d. Nonenjofnjthenjabove
nj 27.n j Hownjisnjstroma-freenjhemoglobinnjsolutionnjprepared?
a. Outdatednjrednjbloodnjcellsnjarenjconcentrated,njandnjstromanjisnjremoved.
b. Outdatednjrednjbloodnjcellsnjarenjdilutednjwithnjsaline,njandnjstromanjisnjremoved.
c. Outdatednjrednjbloodnjcellsnjarenjlysed,njandnjstromanjisnjremoved.
d. Nonenjofnjthenjabove
nj 28.n j WhatnjisnjthenjnormalnjlifenjspannjofnjannjRBC?
a. 100njdays c. 120njhours
b. 120njdays d.n j 2njdays
nj 29.n j RegardingnjlossnjofnjRBCnjmembranenjdeformability,njallnjofnjthenjfollowingnjarenjtruenjexcept:
a. IncreasenjinnjATPnjlevel.
b. DecreasenjinnjATPnjlevel.
Thisnjstudynjsourcenjwasnjdownloadednjbynj100000826342158njfromnjCourseHero.comnjonnj09-15-
2021nj17:54:15njGMTnj-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
Chapternj1njRBCsnjandnjPlateletnjPreservation:njHistoricalnjPerspectivesnjandnjCurrentnjTrends
MultiplenjChoice
Identifynjthenjchoicenjthatnjbestnjcompletesnjthenjstatementnjornjanswersnjthenjquestion.
1. Whichnjmetabolicnjpathwaynjisnjresponsiblenjfornjgeneratingnj90%njofnjthenjATPnjfornjthenjRBC?
a. Pentosenjphosphatenjshunt c. Glycolysis
b. Luebering-Rapoportnjshunt d.n j Methemoglobinnjreductase
2. Anjunitnjofnjbloodnjwasnjreturnednjtonjthenjbloodnjbanknjbeforenjitnjwasnjspiked.njApparentlynjthenjpatient’snjIVnjfaile
d.njThenjunitnjofnjbloodnjwasnjoutsidenjthenjbloodnjbanknjfornj35njminutes.njWhichnjofnjthenjstatementsnjbelownjisnj
mostnjaccurate?
a. Thenjunitnjofnjbloodnjshouldnjbenjdiscardednjimmediately.
b. Thenjunitnjofnjbloodnjcannjbenjreturnednjtonjinventory.
c. Thenjunitnjofnjbloodnjmustnjbenjtransfusednjwithinnj4njhoursnjornjbenjdiscardednjatnjthenjendnjofnjthatnjtime.
d. Thenjunitnjofnjbloodnjmustnjbenjtransfusednjwithnj24njhours.
3. Whatnjisnjthenjaveragenjdiameternjofnjanjplatelet?
a. 5njtonj10njµm c. 1njtonj2njµm
b. 2njtonj4njµm d.n j n j 4njtonj6njµm
4. Innjthenjnormalnjhemoglobin-
oxygennjdissociationnjcurve,njwhatnjpercentagenjofnjoxygennjisnjreleasednjtonjthenjtissuesnjwhennjPO2n j average
snj40njmmnjHg?
a. 75% c. 100%
b. 25% d.n j 50%
5. Whatnjfactorsnjarenjknownnjtonjinfluencenjplateletnjmetabolismnjandnjfunction?
a. Storagenjtemperature c. Plateletnjcount
b. InitialnjpH d.n j Allnjofnjthenjabove
6. Whichnjofnjthenjfollowingnjrednjbloodnjcellnjmorphologiesnjmaynjbenjpresentnjonnjthenjperipheralnjbloodnjsmearnjasnj
anjresultnjofnjlossnjofnjRBCnjmembrane?
a. Spherocytes c. Burrnjcells
b. Targetnjcells d.n j Schistocytes
7. Whatnjdoesnjthenjtermnjautologousnjtransfusionnjrefernjto?
a. Anjparentnjdonatingnjbloodnjfornjhisnjornjhernjchild
b. Annjindividualnjdonatingnjbloodnjfornjanjfriend
c. Annjindividualnjdonatingnjbloodnjfornjanjrelative
d. Annjindividualnjdonatingnjbloodnjfornjhisnjornjhernjownnjtransfusion
8. Whatnjisnjthenjprimarynjfunctionnjofnjhemoglobin?
a. Ironnjmetabolism c. Oxygennjtransport
b. Porphyrinnjsynthesis d.n j Signalnjtransduction
9. Allnjofnjthenjfollowingnjareasnjofnjrednjbloodnjcellnjbiologynjarenjcrucialnjfornjnormalnjerythrocytenjsurvivalnjexcept:
a. Cellularnjmetabolism. c. SitenjofnjthenjABOnjantigennjattachment.
b. RBCnjmembrane. d.n j Hemoglobinnjstructure.
Thisnjstudynjsourcenjwasnjdownloadednjbynj100000826342158njfromnjCourseHero.comnjonnj09-15-
2021nj17:54:15njGMTnj-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
nj 10.n j WhatnjisnjthenjcorrectnjbiochemicalnjcompositionnjofnjthenjRBCnjmembrane?
a. 52%njprotein,nj40%njlipid,nj8%njcarbohydrate
b. 40%njprotein,nj8%njlipid,nj52%njcarbohydrate
c. 8%njprotein,nj52%njlipid,nj40%njcarbohydrate
d. 8%njlipid,nj40%njcarbohydrate,nj52%njprotein
nj 11.n j Allnjofnjthenjfollowingnjbiochemicalnjchangesnjarenjassociatednjwithnjlossnjofnjrednjbloodnjcellnjviabilitynjuponnjstora
ge
except:
a. DecreasednjpH. c. IncreasednjATPnjlevel.
b. Lossnjofnjrednjbloodnjcellnjfunction. d.n j Decreasednjglucosenjconsumption.
nj 12.n j Whichnjrednjbloodnjcellnjpreservativenjhasnjanjstoragenjtimenjofnj35njdays?
a. ACD c. AS-1
b. CPDA-1 d.n j n j CPD
nj 13.n j ThenjRBCnjmembranenjisnjrelativelynjpermeablenjtonjallnjofnjthenjfollowingnjexcept:
a. Chloride. c. Bicarbonate.
b. Sodium. d.n j Water.
nj 14.njWhatnjpercentagenjofnjplateletsnjisnjsequesterednjinnjthenjspleennjasnjfunctionalnjreservenjafternjbeingnjreleasednjfr
omnjthenjbonenjmarrow?
a. 30% c. 10%
b. 50% d.n j n j 25%
nj 15.n j Whatnjisnjthenjmajornjbiochemicalnjconsiderationnjinnjplateletnjstorage?
a. Glucosenjmetabolism c. Productionnjofnjcarbonnjdioxide
b. Oxygennjsupply d.n j RegulationnjofnjpH
nj 16.njWhatnjwouldnjthenjhemoglobin-
oxygennjdissociationnjcurvenjdepictnjinnjanjpatientnjexhibitingnjclinicalnjsignsnjofnjalkalosis?
a. Normal c. Shiftnjtonjthenjright
b. Shiftnjtonjthenjleft d.n j Nonenjofnjthenjabove
nj 17.n j Namenjthenjmainnjlipidnjcomponentsnjofnjanjrednjbloodnjcellnjmembrane.
a. Phospholipid c. Glycolipid
b. Sphingomyelin d.n j GlycophorinnjA
nj 18.n j ThenjABOnjbloodnjgroupsnjwerenjdiscoverednjinnj1901njbynjwhom?
a. CharlesnjDrew c. LoutitnjandnjMollison
b. KarlnjLandsteiner d.n j EdwardnjLindeman
nj 19.njAnjstandingnjordernjofnjplateletsnjwasnjshippednjtonjyournjfacilitynjbynjyournjsupplier.njItnjwasnjinadvertentlynjleftnj
innjthenjcornernjofnjthenjdepartmentnjuntilnjdiscoverednj36njhoursnjlater.njWhatnjwouldnjthenjappropriatenjactionnjbenj
fornjthenjbloodnjbanker?
a. Ifnjthenjtemperaturenjinnjthenjboxnjwasnj22nj+/-
nj2°CnjandnjthenjplateletnjswirlnjseemednjOK,njitnjwouldnjbenjOKnjtonjacceptnjthenjunitnjintonjinven
tory.
b. Thenjplateletsnjhavenjfallennjoutsidenjthenjsupplier’snjqualitynjassurance.njThenjunitnjshouldnj
benjdiscardednjbecausenjthenjpHnjhasnjprobablynjdroppednjtoonjlownjandnjplateletnjactivationnj
hasnjbeennjcompromised.
c. Ifnjthenjtemperaturenjwasnj1°Cnjtonj6°CnjandnjthenjplateletnjswirlnjseemednjOK,njitnjwouldnjbenjOKnjto
Thisnjstudynjsourcenjwasnjdownloadednjbynj100000826342158njfromnjCourseHero.comnjonnj09-15-
2021nj17:54:15njGMTnj-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
acceptnjthenjunitnjintonjinventory.
d. IfnjthenjplateletsnjappearednjOKnjandnjpassednjthenjplateletnjswirlnjtestnjafternjbeingnjplacednj
onnjthenjagitator,njtheynjcouldnjbenjacceptednjintonjthenjinventory.
nj 20.n j Whichnjmetabolicnjpathwaynjpermitsnjthenjaccumulationnjofnj2,3njdiphosphoglyceratenj(2,3-DPG)?
a. Glycolysis c. Pentosenjphosphatenjshunt
b. Luebering-Rapoportnjshunt d.n j Methemoglobinnjreductase
n j 21.n j Allnjofnjthenjfollowingnjarenjconsistentnjwithnjanj"shiftnjtonjthenjright"njofnjthenjhemoglobin-
oxygennjdissociationnjcurve
except:
a. Increasednj2,3-DPG.
b. 50%njO2n j saturationnjtonjtissues.
c. Decreasednj2,3-DPG.
d. DecreasednjhemoglobinnjaffinitynjfornjO2.
nj 22.n j Whatnjisnjthenjnormalnjplateletnjcountnjrangenjpernjcubicnjmillimeter?
a. 100njtonj350 c. 50,000njtonj200,000
b. 150,000njtonj350,000 d.n j 350,000njtonj500,000
nj 23.n j Whatnjcryoprotectivenjagentnjisnjaddednjtonjrednjbloodnjcellsnjuponnjfreezing?
a. Dextrose c. Glycerol
b. Adsol d.n j Allnjofnjthenjabove
nj 24.n j Ifnjplateletsnjarenjtonjbenjstorednjfornj5njdaysnjonnjanjrotator,njwhatnjisnjthenjoptimalnjstoragenjtemperature?
a. 1°Cnjtonj6°C c. 35°Cnjtonj37°C
b. 20°Cnjtonj24°C d.n j 1°Cnjtonj10°C
nj 25.n j Whatnjrolenjdonjplateletsnjplaynjinnjhemostasis?
a. Maintenancenjofnjvascularnjintegrity
b. Initialnjarrestnjofnjbleedingnjbynjplateletnjplugnjformation
c. Stabilizationnjofnjthenjhemostaticnjplug
d. Allnjofnjthenjabove
nj 26.n j Whichnjofnjthenjfollowingnjbestnjdescribesnj"integral"njmembranenjproteins?
a. Residenjatnjthenjcytoplasmicnjsurfacenjofnjmembrane
b. Spannjthenjentirenjmembranenjsurface
c. Formnjthenjrednjbloodnjcellnjcytoskeleton
d. Nonenjofnjthenjabove
nj 27.n j Hownjisnjstroma-freenjhemoglobinnjsolutionnjprepared?
a. Outdatednjrednjbloodnjcellsnjarenjconcentrated,njandnjstromanjisnjremoved.
b. Outdatednjrednjbloodnjcellsnjarenjdilutednjwithnjsaline,njandnjstromanjisnjremoved.
c. Outdatednjrednjbloodnjcellsnjarenjlysed,njandnjstromanjisnjremoved.
d. Nonenjofnjthenjabove
nj 28.n j WhatnjisnjthenjnormalnjlifenjspannjofnjannjRBC?
a. 100njdays c. 120njhours
b. 120njdays d.n j 2njdays
nj 29.n j RegardingnjlossnjofnjRBCnjmembranenjdeformability,njallnjofnjthenjfollowingnjarenjtruenjexcept:
a. IncreasenjinnjATPnjlevel.
b. DecreasenjinnjATPnjlevel.
Thisnjstudynjsourcenjwasnjdownloadednjbynj100000826342158njfromnjCourseHero.comnjonnj09-15-
2021nj17:54:15njGMTnj-05:00
https://www.coursehero.com/file/25537437/ch01rtf/
