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NBME CBSE Real Exam 2026–2027 – 200 Verified Questions & Correct Answers | USMLE Step 1 Latest Updates

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This document is a complete and verified question bank for the NBME CBSE Real Exam 2026–2027, containing 200 actual exam questions with accurate, detailed answers. Designed for medical students preparing for USMLE Step 1, it provides an authentic and high-yield resource that reflects the latest exam updates, format, and clinical relevance. The test bank covers all essential preclinical subjects tested on Step 1, including Anatomy, Physiology, Biochemistry, Pathology, Microbiology, Pharmacology, Behavioral Science, Genetics, Immunology, and Biostatistics/Epidemiology. Each question comes with a verified correct answer and detailed explanation, enabling students to understand the reasoning behind each solution, identify knowledge gaps, and strengthen clinical reasoning skills. This resource emphasizes critical thinking, problem-solving, and application of foundational medical knowledge, preparing students for both the NBME CBSE and USMLE Step 1 exams. It is ideal for self-assessment, mock exams, revision, and high-yield review, helping students improve speed, accuracy, and confidence under exam conditions. NBME CBSE 2026–2027 test bank USMLE Step 1 practice questions medical exam verified answers CBSE real exam questions high-yield USMLE Step 1 prep medical student self-assessment preclinical exam practice NBME CBSE mock test questions verified correct answers CBSE USMLE Step 1 latest updates

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Institution
NBME CBSE
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NBME CBSE

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Uploaded on
January 24, 2026
Number of pages
60
Written in
2025/2026
Type
Exam (elaborations)
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Questions & answers

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NBME CBSE REAL EXAM 200
QUESTIONS AND ANSWERS LATEST
2026-2027 (USMLE STEP 1)MEDICAL
EXAMINATION LATEST UPDATES QUESTIONS
AND CORRECT ANSWERS



70yo M dies in a motor vehicle collision. Was undergoing evaluation
for occult blood in the stool. Photo of transverse colon shown. Dx? -
ANSWER- Tubular adenoma


38yo M with 1-week hx of watery, itchy eyes and a runny nose. Physical
shows inflamed nasal mucosa. No congestion in lower lung.
Pharmacotherapy? - ANSWER- Loratadine



16yo girl with 3-day hx of fever, nonproductive cough, and fatigue. T
38.3, P 88/min, BP 102-70. PE shows pale conjunctivae. CXR shows
bilateral interstitial infiltrates. Blood spontaenously agglutinates while
awaiting transport to the laboratory. Antibody isotypes causing
agglutination? - ANSWER- IgM

24yo M with small tender blisters on his penis 3 days after unprotected
sex. Photograph shown. Causal agent? - ANSWER- HSV-2

, NBME CBSE REAL EXAM 200 QUESTIONS AND
ANSWERS LATEST 2026-2027 (usmle step
1)MEDICAL
EXAMINATION LATEST UPDATES JUNE 2023 A GRADE.


42yo F with 3-year hx of an intermittent facial rash, including the
forehead, eyelids, nose, and cheeks. Rash seems to be getting worse
since she moved from New York to Florida last year. Spicy foods
precipitate a flushing reaction that seems to exacerbate the rash. PE
shows erythema over the nose and cheeks, with scattered telangiectasias
and a few papules. Dx? - ANSWER- Rosacea
53yo M returned from Africa, has fever, headache, and abdominal
discomfort. Received appropriate vaccinations prior to the trip. T
39.4C.
A wright-stained peripheral smear shown. Dx? - ANSWER- Malaria


68yo F with T2DM and hypertension that has been poorly controlled
despite hydrochlorothiazide treatment. BP 150/96, Labs show serum
glucose concentration of 130 and proteinuria. In addition to current x,



which is most appropriate pharmacotherapy? - ANSWER- Lisinopril

66yo M with stage IV colon cancer with 3-day hx of severe diarrhea
after receiving chemotherapy with fluorouracil, leucovorin, and
Irinotecan. prescribed opioid antidiarrheal agent with no CNS effects.
Which med? - ANSWER- Loperamide

,35yo M in ED with 2-hour hx of sever fatigue and dizziness. Had
profuse, watery diarrhea for 8 hours despite a lack of oral intake.
RecentlyNBME
returnedCBSE
from aREAL EXAM
medical relief 200
trip QUESTIONS ANDin
to a remove village
ANSWERS
Honduras. T 36.7 C,LATEST
P 122/min,2026-2027
BP 90/50.(usmle step 1)MEDICAL
PE shows dry skin and
decreasedEXAMINATION
capillary refill. Stool for occult
LATEST blood is JUNE
UPDATES negative;
2023stool
A is
gray and turbid. Gram stain shows gram-negative, comma-shaped
bacteria; no erythrocytes of leukocytes. MOA of toxin? - ANSWER-
Activation

of adenylyl cyclase


59yo F with gradual onset of lack of muscle control in her left arm and
leg. Sx 1 mo ago after dx with metastatic breast cancer. PE shows
ataxia
of left upper and lower extremities. Muscle strength, DTR, sensation,
proprioception
cerebellum normal. Metastatic tumor in which location? -
ANSWER- GRADE.

, NBME CBSE REAL EXAM 200 QUESTIONS AND
ANSWERS LATEST 2026-2027 (usmle step 1)MEDICAL
EXAMINATION LATEST UPDATES JUNE 2023 A GRADE.


Newborn delivered at 38 weeks' gestation weighs 1800 g. PE shows
petechial rash, microcephaly, and hepatosplenomegaly. Serologic test for
CMV: IgG + in mother, + in newborn; IGM - in mother, + in newborn.
Explanation? - ANSWER- Congenital cytomegalovirus infection
Female newborn is delivered at 38 weeks' gestation. Apgar 8 and 8 at 1/5
min. PE shows a bulging, fluod0filled mass approximately 5 cm in
diameter in the midline over the lumbosacral region. No spontaneous
movements of the lower extremities. Abnormality most likely
occurred because of abnormal development during which periods of
postconception (in days)? - ANSWER- 15 to 40



64yo M in ED 3 hours after SOB with exertion and extreme fatigue. Has
ischemic heart disease. P 125/min, BP 105/60. ECG shows atrial
fibrillation. Intravenous ibutilide is administered. Ten minutes later,
ECG shows normal sinus rhythm. Risk for which drug effect in the
next 6 hours? - ANSWER- torsades de pointes


65yo F with 20-year hx of osteoarthritis of the hands now has pain
radiating down the distal anterior thigh, knee, medial leg, and food.
Bony outgrowth of vertebrae compressing one of the spinal nerves
is suspected. Nerve root in which intervertebral foramina is
effected? - ANSWER- L3 to L4

38yo M with 3-year hx of T2DM. Taking an oral antihyperglycemic
agent, he has tried diet and exercise. BMI 32. PE normal. Hb A1c is
10%. Physician recommends initiation of insulin injections. Responds, "I
know that insulin would help control my blood sugar. But a lot of
people in my family have diabetes, and insulin made them really sick at
times.
Patient is at which stage of change? - ANSWER- contemplation

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