GMS 6474 final exam QUESTIONS WITH
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ANSWERS
what does the SR store - CORRECT ANSWERS ✔✔proteins
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and calcium
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what is the role of the transverse tubules in the muscle
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
fiber - CORRECT ANSWERS ✔✔allow inside of muscle to
|\ |\ |\ |\ |\ |\ |\ |\ |\
communicate with the outside of the muscle |\ |\ |\ |\ |\ |\
how is a sarcomere measured - CORRECT ANSWERS
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✔✔from z-disc to z-disc |\ |\ |\
what is contained in the I band of the sarcomere & what
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color is the band - CORRECT ANSWERS ✔✔thin filaments
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titin |\
z-disc
light (isotropic)
|\
what is contained in the A band of the sarcomere & what
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
color is the band - CORRECT ANSWERS ✔✔thick filaments
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thin filaments
|\ |\
dark (scatters light)
|\ |\
,what is contained in the H zone & what color is the band -
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CORRECT ANSWERS ✔✔thick filaments
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light |\
no barbs or myosin
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middle zone of the sarcomere |\ |\ |\ |\
what is contained in the M line - CORRECT ANSWERS
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✔✔in the middle of the sarcomere, middle of H zone
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thick filaments |\ |\
myomesin
what does titin do in the sarcomere - CORRECT ANSWERS
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✔✔structural protein |\
how many zones can you see when the sarcomere is
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relaxed - CORRECT ANSWERS ✔✔all zones can be seen in
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
relaxed state |\
how many zones can be seen when the sarcomere is
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contracted - CORRECT ANSWERS ✔✔sarcomere shortens |\ |\ |\ |\ |\ |\
I band shortens
|\ |\ |\
H zone disappears
|\ |\ |\
thick and thin filaments overlap DONT shorten
|\ |\ |\ |\ |\ |\
,what is the contractile unit of skeletal muscle - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔the sarcomere |\ |\
what is the main component of the thick filaments -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔myosin |\ |\
have heavy and light chains
|\ |\ |\ |\ |\
motor heads that move it along the thin filament
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what is the largest protein in the body - CORRECT
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ANSWERS ✔✔titin |\
what are the main components of the thin filaments -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔actin (where myosin binds)
|\ |\ |\ |\ |\
troponin (moves tropomyosin when Ca2+ is present)
|\ |\ |\ |\ |\ |\
tropomyosin (covers actin active site) |\ |\ |\ |\
nebulin (sets thin filament length)
|\ |\ |\ |\ |\
CapZ (anchors actin to Z-line on z-disc side)
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Tropomodulin (on end of actin, in middle of sarcomere) |\ |\ |\ |\ |\ |\ |\ |\
alpha-actinin (anchors actin to z-line) |\ |\ |\ |\
what does desmin do in the sarcomere - CORRECT
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ANSWERS ✔✔interacts with alpha-actinin to anchor z-disc
|\ |\ |\ |\ |\ |\
to sarcolemma
|\ |\
, what does dystrophin do in the sarcomere - CORRECT
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ANSWERS ✔✔connects sarcomere to sarcolemma |\ |\ |\ |\ |\
stabilizes the sarcolemma to prevent damage during
|\ |\ |\ |\ |\ |\ |\
contractions
1st step of cross-bridge cycle - CORRECT ANSWERS
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✔✔BINDING |\
activated myosin binds to actin |\ |\ |\ |\ |\
ADP and Pi are still bound to myosin
|\ |\ |\ |\ |\ |\ |\
2nd step of cross bridge cycle - CORRECT ANSWERS
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✔✔POWER STROKE |\ |\
myosin head swivels |\ |\
movement of actin filament |\ |\ |\
ADP and Pi released from myosin
|\ |\ |\ |\ |\
(Pi is released first, before ADP is released)
|\ |\ |\ |\ |\ |\ |\
3rd step of cross bridge cycle - CORRECT ANSWERS
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✔✔DISSOSCIATION
ATP binds to myosin
|\ |\ |\ |\
Actin and myosin dissociate (cross bridge detaches)
|\ |\ |\ |\ |\ |\
|\ |\ |\ |\ |\ |\
ANSWERS
what does the SR store - CORRECT ANSWERS ✔✔proteins
|\ |\ |\ |\ |\ |\ |\ |\ |\
and calcium
|\
what is the role of the transverse tubules in the muscle
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
fiber - CORRECT ANSWERS ✔✔allow inside of muscle to
|\ |\ |\ |\ |\ |\ |\ |\ |\
communicate with the outside of the muscle |\ |\ |\ |\ |\ |\
how is a sarcomere measured - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\
✔✔from z-disc to z-disc |\ |\ |\
what is contained in the I band of the sarcomere & what
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
color is the band - CORRECT ANSWERS ✔✔thin filaments
|\ |\ |\ |\ |\ |\ |\ |\ |\
titin |\
z-disc
light (isotropic)
|\
what is contained in the A band of the sarcomere & what
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
color is the band - CORRECT ANSWERS ✔✔thick filaments
|\ |\ |\ |\ |\ |\ |\ |\ |\
thin filaments
|\ |\
dark (scatters light)
|\ |\
,what is contained in the H zone & what color is the band -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔thick filaments
|\ |\ |\ |\ |\
light |\
no barbs or myosin
|\ |\ |\ |\
middle zone of the sarcomere |\ |\ |\ |\
what is contained in the M line - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔in the middle of the sarcomere, middle of H zone
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
thick filaments |\ |\
myomesin
what does titin do in the sarcomere - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔structural protein |\
how many zones can you see when the sarcomere is
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
relaxed - CORRECT ANSWERS ✔✔all zones can be seen in
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
relaxed state |\
how many zones can be seen when the sarcomere is
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
contracted - CORRECT ANSWERS ✔✔sarcomere shortens |\ |\ |\ |\ |\ |\
I band shortens
|\ |\ |\
H zone disappears
|\ |\ |\
thick and thin filaments overlap DONT shorten
|\ |\ |\ |\ |\ |\
,what is the contractile unit of skeletal muscle - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔the sarcomere |\ |\
what is the main component of the thick filaments -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔myosin |\ |\
have heavy and light chains
|\ |\ |\ |\ |\
motor heads that move it along the thin filament
|\ |\ |\ |\ |\ |\ |\ |\
what is the largest protein in the body - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔titin |\
what are the main components of the thin filaments -
|\ |\ |\ |\ |\ |\ |\ |\ |\ |\
CORRECT ANSWERS ✔✔actin (where myosin binds)
|\ |\ |\ |\ |\
troponin (moves tropomyosin when Ca2+ is present)
|\ |\ |\ |\ |\ |\
tropomyosin (covers actin active site) |\ |\ |\ |\
nebulin (sets thin filament length)
|\ |\ |\ |\ |\
CapZ (anchors actin to Z-line on z-disc side)
|\ |\ |\ |\ |\ |\ |\
Tropomodulin (on end of actin, in middle of sarcomere) |\ |\ |\ |\ |\ |\ |\ |\
alpha-actinin (anchors actin to z-line) |\ |\ |\ |\
what does desmin do in the sarcomere - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔interacts with alpha-actinin to anchor z-disc
|\ |\ |\ |\ |\ |\
to sarcolemma
|\ |\
, what does dystrophin do in the sarcomere - CORRECT
|\ |\ |\ |\ |\ |\ |\ |\ |\
ANSWERS ✔✔connects sarcomere to sarcolemma |\ |\ |\ |\ |\
stabilizes the sarcolemma to prevent damage during
|\ |\ |\ |\ |\ |\ |\
contractions
1st step of cross-bridge cycle - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\
✔✔BINDING |\
activated myosin binds to actin |\ |\ |\ |\ |\
ADP and Pi are still bound to myosin
|\ |\ |\ |\ |\ |\ |\
2nd step of cross bridge cycle - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔POWER STROKE |\ |\
myosin head swivels |\ |\
movement of actin filament |\ |\ |\
ADP and Pi released from myosin
|\ |\ |\ |\ |\
(Pi is released first, before ADP is released)
|\ |\ |\ |\ |\ |\ |\
3rd step of cross bridge cycle - CORRECT ANSWERS
|\ |\ |\ |\ |\ |\ |\ |\ |\
✔✔DISSOSCIATION
ATP binds to myosin
|\ |\ |\ |\
Actin and myosin dissociate (cross bridge detaches)
|\ |\ |\ |\ |\ |\
