ALAT - The Guide Questions and Answers

ALAT - The Guide

The Guide defines a laboratory animals as any ________________ animal produced for
or used in research, testing, or teaching - answer vertebrate

the main objective of the Guide is to provide information to institutions in maintaining
________________ research programs, and to enhance animal _____________, the
quality of research, and the _______________ of science - answer high-quality, well-
being, advancement

which one of the three Rs is described here
- methods that avoid using animals
- examples: using tissue or cell culture, computer modeling, or using invertebrates
instead of vertebrates - answer replacement

which one of the three Rs is described here:
- modifications to procedures on animals that enhance animal well-being and reduce or
eliminate pain and distress
- example: using more effective or longer lasting analgesics - answerrefinement

which of the three Rs is described here:
- the use of fewer numbers of animals, without compromising scientifically valid results -
answerreduction

____________________ standards specify a method for achieving an outcome, and do
not leave room for modification for alternative methods - answerengineering

______________ standards describe a guideline that provides for flexibility in achieving
a desired outcome - answerperformance

the use and application of professional judgment over time, which has shown to have
positive impact on animal care and use - answerpractice standards

statements of management direction or collective wisdom that are internal to an
institution or entity - answerpolicies

usually more broadly defined and used
generalizations on topics endorsed by many entities - answerPrinciples

often called SOPs
detailed, defined processes that are used to standardize the method for performing
specific institutional practices - answerprocedures

, who is a part of the intended audience for the guide?
a) producers of laboratory animals
b) administrators
c) veterinarians
d) the public
e) all of the above - answere

what is NOT used to relieve the pain or distress of an animal undergoing a procedure?
a) sedation
b) anesthesia
c) paralyzing agent
d) analgesia - answerc

which action is an example of replacement?
a) using tissue cultures for in vitro studies
b) providing better housing for the animals
c) using longer lasting analgesics
d) conducting a small pilot study to see if a larger study is appropriate - answera

for which animals does the Guide provide specific details and requirements for use in
research?
a) wildlife in natural settings
b) agricultural animals used for agricultural research
c) agricultural animals produced for food production
d) invertebrates used for research
e) none of the above
d) all of the above - answere

The _____________________ has the ultimate responsibility for the entire animal care
and use program at an institution
- has authority to allocate resources to the program so it will run effectively -
answerInstitutional Official

The ___________________ is responsible for the health and well-being of all the
laboratory animals used at the institution - answerAttending Veterinarian

responsible for the oversight of the animal care and use program as well as for its
assessment - answerthe IACUC

whose responsibility is it to ensure that all personnel working with live animals have
been properly and appropriately trained? - answerIACUC

The ____________'s publication Occupational Health and Safety in the Care and Use
of Research Animals contains information, guidelines and references for a
comprehensive and effective OHSP - answerNational Research Council's