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Glucose regulation: The regulation of glucose concentrations in the blood,
blood sugar concentration, is a homeostatic process that's essential for
maintaining cellular respiration and health in general. Two basic processes
regulate the level of glucose in your blood. One removes glucose from your
blood, lowering your blood sugar levels. The other releases glucose into
your blood, increasing your blood sugar levels. When two processes
operate together efficiently, they ensure that your blood sugar levels remain
within a relatively narrow range around a set point of about 90 mg/dL of
glucose. - 🧠 ANSWER ✔✔Insulin signaling is essential to the process that
removes glucose from your blood. Pancreatic b cells release insulin as
,glucose levels start to rise. Insulin then stimulates cells to insert glucose
transporters, GLUT4 transporters, into their cell membranes. The operation
of these transporters pulls glucose from the blood into the cells and stores
much of it in the form of glycogen, lowering blood sugar levels in the
process. When glucose levels are too low, pancreatic a cells release
glucagon. This hormone stimulates cells, especially liver cells, to covert the
glycogen back into glucose and release to release that glucose into the
circulatory system, increasing blood sugar levels. For the test, you should
be able to do the following
• Explain the difference between Type 1 and Type 2 diabetes
• Predict when insulin and glucagon will be released
• Predict the effects that insulin and glucagon will have on blood sugar
levels
• Explain how and why diabetes, either Type 1 or Type 2, disrupts the
homeostatic regulation of blood sugar levels
• Explain how high blood sugar levels my impact your health using
hemoglobin A1C as an example - 🧠 ANSWER ✔✔1. Explain the difference
between Type 1 and Type 2 diabetes:
,- Type 1 diabetes is an autoimmune condition where the body doesn't
produce insulin, while Type 2 diabetes is characterized by insulin
resistance, where the body's cells don't respond effectively to insulin.
2. Predict when insulin and glucagon will be released:
- Insulin is released when blood glucose levels rise, typically after a meal,
whereas glucagon is released when glucose levels are low, usually
between meals or during fasting.
3. Predict the effects that insulin and glucagon will have on blood sugar
levels:
- Insulin lowers blood sugar levels by facilitating the uptake of glucose into
cells, while glucagon raises blood sugar levels by promoting the conversion
of glycogen into glucose and releasing it into the bloodstream.
4. Explain how and why diabetes, either Type 1 or Type 2, disrupts the
homeostatic regulation of blood sugar levels:
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, - In Type 1 diabetes, the absence of insulin leads to uncontrolled high
blood sugar, while in Type 2 diabetes, insulin resistance impairs the normal
regulation of glucose levels, resulting in elevated blood sugar.
5. Explain how high blood sugar levels may impact your health using
hemoglobin A1C as an example:
- Prolonged high blood sugar levels, as reflected by elevated hemoglobin
A1C levels, can lead to complications such as cardiovascular disease,
kidney damage, and nerve damage, highlighting the importance of
maintaining glucose homeostasis for overall health.
Regulation of blood gasses, oxygen and carbon dioxide: The regulation of
blood gasses is essential for maintaining sufficient oxygen levels in the
blood to support cellular respiration. Gas exchange between atmospheric
air and the blood occurs in the alveoli of the lungs. Oxygen diffuses down
its concentration gradient from the alveoli into the blood by first dissolving
in the fluid coating the inside of the alveoli. It then diffuses across the
alveolar walls, the capillary walls and finally binds to hemoglobin in red
blood cells. It then circulates through the body and once again diffuses
down its concentration in respiring tissues (tissues that are consuming