Written by students who passed Immediately available after payment Read online or as PDF Wrong document? Swap it for free 4.6 TrustPilot
logo-home
Previously searched by you
Previously searched by you
logo
  • Universiteit Utrecht (UU)
  • Oncologie (FABA304)
To add items to your wishlist, you must be logged in
Summary

H3 book summary - lauren pecorino

Rating
-
Sold
-
Pages
2
Uploaded on
15-01-2026
Written in
2025/2026

H4 summary of the book as a word document

Institution
Universiteit Utrecht (UU)
Course
Oncologie (FABA304)

Content preview

Hoorcollege Genoominstabiliteit
Aniek Janssen UMC
Instabiliteit = continuous changes to the genome
 terwijl normaal wil je dat het DNA stabiel is en niet verandert

Chromosomale instability
- Anauploidy = abnormale hoeveelheid chromosomen
- Op chromosomal niveau
- Extra chromosoom erbij
- Chromosoom minder

Nucleotide instability

Anauploidy = abnormale hoeveelheid chromosomen
 extra oncogenen
 verlies tumor suppressor genen

Functie eiwit veranderd

Aneuploidy is caused by chromosome missegregations
Misalignment chromosome  ongelijke verdeling chromosome

Aanwezige metabolieten in de cel kunnen carcinogen zijn
- Formaldehyde

Roet bevat carcinogenen  betere bescherming

Chromium zat in verf

DNA schades aan 1 kant van de streng:
1: Mismatch repair
- Na DNA replicatie, wanneer een verkeerde base is
geincopereerd  kan niet baseparen
EXO1 = knipt DNA  base gaat weg

2: Base exision repair
- Subtielere verandering; gemethyleerde base

3: Nucleotide exision repair
Thymine dimeer = Covalente binding tussen de T basen

Detecteren van dsDNA breuk: NHEJ, HR
NHEJ  kan leiden tot korte inserties of deleties
- Snel
- Niet nauwkeurig



Hoorcollege deel 2
Report Copyright Violation

Written for

Institution
Universiteit Utrecht (UU)
Study
Farmacie
Course
Oncologie (FABA304)

Document information

Uploaded on
January 15, 2026
Number of pages
2
Written in
2025/2026
Type
SUMMARY

Subjects

  • subtest
  • dt1
  • oncology
  • h3
$8.81
Get access to the full document:
Wrong document? Swap it for free Within 14 days of purchase and before downloading, you can choose a different document. You can simply spend the amount again.
Written by students who passed
Immediately available after payment
Read online or as PDF
Get to know the seller
Seller avatar
mklyeung246

Also available in package deal

Thumbnail
Package deal
deeltoets 1 oncologie - boek samenvatting lauren pecorino
-
10 2026
$ 36.49 More info

Get to know the seller

Seller avatar
mklyeung246
View profile
Follow You need to be logged in order to follow users or courses
Sold
2
Member since
5 year
Number of followers
2
Documents
11
Last sold
2 year ago

0.0

0 reviews

5
0
4
0
3
0
2
0
1
0

Why students choose Stuvia

Created by fellow students, verified by reviews

Quality you can trust: written by students who passed their tests and reviewed by others who've used these notes.

Didn't get what you expected? Choose another document

No worries! You can instantly pick a different document that better fits what you're looking for.

Pay as you like, start learning right away

No subscription, no commitments. Pay the way you're used to via credit card and download your PDF document instantly.

Student with book image

“Bought, downloaded, and aced it. It really can be that simple.”

Alisha Student

Working on your references?

Create accurate citations in APA, MLA and Harvard with our free citation generator.

Learn more Create citation
Working on your references?

Frequently asked questions