1|Page
NR 565 Advanced Pharmacology – Week 1
Quiz (Actual Exam Style, 2026 Edition)
Comprehensive 100 Questions with Verified
Answers and Detailed Rationales | Instant
Pdf Download
Introduction
Welcome to the NR 565 Advanced Pharmacology Week 1 Quiz,
designed to simulate the actual exam experience for graduate-level
nursing students. This quiz includes 100 of the most tested, high-yield
questions, divided into two batches of 50 questions each, covering
pharmacokinetics, pharmacodynamics, cardiovascular, endocrine,
respiratory, and emergency pharmacology.
Each question includes:
Bolded correct answers for clarity
Verified rationales to reinforce understanding
Focus on clinical application and critical thinking for advanced
nursing practice
This quiz is an essential study and review tool, helping students master
core concepts, drug mechanisms, therapeutic uses, and adverse
effects, while preparing for high-stakes assessments in pharmacology.
Question 1
Which term describes the movement of a drug from its site of
administration into the bloodstream?
A) Distribution
B) Absorption
C) Metabolism
D) Excretion
Correct Answer: B
Rationale: Absorption is the process by which a drug enters systemic
circulation, determining the onset of action.
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Question 2
Which route of administration typically results in the fastest drug
absorption?
A) Oral
B) Subcutaneous
C) Intravenous (IV)
D) Topical
Correct Answer: C
Rationale: IV administration delivers the drug directly into circulation,
bypassing absorption barriers.
Question 3
A drug with a high first-pass effect:
A) Has enhanced oral bioavailability
B) Is rapidly excreted by the kidneys
C) Undergoes extensive metabolism in the liver before reaching
systemic circulation
D) Accumulates in fat tissue
Correct Answer: C
Rationale: First-pass metabolism in the liver reduces the amount of
active drug entering systemic circulation after oral administration.
Question 4
Which organ is primarily responsible for drug metabolism?
A) Kidney
B) Liver
C) Lung
D) Spleen
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Correct Answer: B
Rationale: The liver metabolizes drugs via phase I (oxidation, reduction,
hydrolysis) and phase II (conjugation) reactions.
Question 5
Which term describes the movement of a drug from the bloodstream to
tissues?
A) Absorption
B) Metabolism
C) Distribution
D) Excretion
Correct Answer: C
Rationale: Distribution is the process by which a drug is transported
from the circulation to various body tissues.
Question 6
Which factor affects drug distribution?
A) Blood flow to tissues
B) Protein binding
C) Lipid solubility
D) All of the above
Correct Answer: D
Rationale: Distribution depends on tissue perfusion, plasma protein
binding, and the drug’s ability to cross cell membranes.
Question 7
A drug with high protein binding will:
A) Have a larger volume of distribution
B) Have a slower onset and longer duration
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C) Be excreted faster
D) Be more water-soluble
Correct Answer: B
Rationale: Protein-bound drugs are inactive while bound, slowing onset
but prolonging duration.
Question 8
Which organ is primarily responsible for drug excretion?
A) Liver
B) Kidneys
C) Lungs
D) Pancreas
Correct Answer: B
Rationale: The kidneys excrete drugs and metabolites via urine, using
filtration, secretion, and reabsorption.
Question 9
A patient has renal impairment. Which pharmacokinetic process is most
affected?
A) Absorption
B) Distribution
C) Metabolism
D) Excretion
Correct Answer: D
Rationale: Renal impairment reduces drug elimination, increasing the
risk of toxicity.
Question 10
NR 565 Advanced Pharmacology – Week 1
Quiz (Actual Exam Style, 2026 Edition)
Comprehensive 100 Questions with Verified
Answers and Detailed Rationales | Instant
Pdf Download
Introduction
Welcome to the NR 565 Advanced Pharmacology Week 1 Quiz,
designed to simulate the actual exam experience for graduate-level
nursing students. This quiz includes 100 of the most tested, high-yield
questions, divided into two batches of 50 questions each, covering
pharmacokinetics, pharmacodynamics, cardiovascular, endocrine,
respiratory, and emergency pharmacology.
Each question includes:
Bolded correct answers for clarity
Verified rationales to reinforce understanding
Focus on clinical application and critical thinking for advanced
nursing practice
This quiz is an essential study and review tool, helping students master
core concepts, drug mechanisms, therapeutic uses, and adverse
effects, while preparing for high-stakes assessments in pharmacology.
Question 1
Which term describes the movement of a drug from its site of
administration into the bloodstream?
A) Distribution
B) Absorption
C) Metabolism
D) Excretion
Correct Answer: B
Rationale: Absorption is the process by which a drug enters systemic
circulation, determining the onset of action.
,2|Page
Question 2
Which route of administration typically results in the fastest drug
absorption?
A) Oral
B) Subcutaneous
C) Intravenous (IV)
D) Topical
Correct Answer: C
Rationale: IV administration delivers the drug directly into circulation,
bypassing absorption barriers.
Question 3
A drug with a high first-pass effect:
A) Has enhanced oral bioavailability
B) Is rapidly excreted by the kidneys
C) Undergoes extensive metabolism in the liver before reaching
systemic circulation
D) Accumulates in fat tissue
Correct Answer: C
Rationale: First-pass metabolism in the liver reduces the amount of
active drug entering systemic circulation after oral administration.
Question 4
Which organ is primarily responsible for drug metabolism?
A) Kidney
B) Liver
C) Lung
D) Spleen
,3|Page
Correct Answer: B
Rationale: The liver metabolizes drugs via phase I (oxidation, reduction,
hydrolysis) and phase II (conjugation) reactions.
Question 5
Which term describes the movement of a drug from the bloodstream to
tissues?
A) Absorption
B) Metabolism
C) Distribution
D) Excretion
Correct Answer: C
Rationale: Distribution is the process by which a drug is transported
from the circulation to various body tissues.
Question 6
Which factor affects drug distribution?
A) Blood flow to tissues
B) Protein binding
C) Lipid solubility
D) All of the above
Correct Answer: D
Rationale: Distribution depends on tissue perfusion, plasma protein
binding, and the drug’s ability to cross cell membranes.
Question 7
A drug with high protein binding will:
A) Have a larger volume of distribution
B) Have a slower onset and longer duration
, 4|Page
C) Be excreted faster
D) Be more water-soluble
Correct Answer: B
Rationale: Protein-bound drugs are inactive while bound, slowing onset
but prolonging duration.
Question 8
Which organ is primarily responsible for drug excretion?
A) Liver
B) Kidneys
C) Lungs
D) Pancreas
Correct Answer: B
Rationale: The kidneys excrete drugs and metabolites via urine, using
filtration, secretion, and reabsorption.
Question 9
A patient has renal impairment. Which pharmacokinetic process is most
affected?
A) Absorption
B) Distribution
C) Metabolism
D) Excretion
Correct Answer: D
Rationale: Renal impairment reduces drug elimination, increasing the
risk of toxicity.
Question 10
