Pathopharmacological Foundations
2025/2026 Exam Questions and Answers
| 100% Solved
What are some physical changes from Alzheimer's dementia? - 🧠
ANSWER ✔✔- Brain shrinks dramatically; nerve cell death and tissue loss
- Cardinal signs: plaques (abnormal clusters of protein fragments) and
tangles (twisted strands of another protein)
How is Alzheimer's treated? - 🧠 ANSWER ✔✔- There is no cure, but there
are pharmacological and non-pharmacological treatments
- Cholinesterase inhibitors
,- Memantine (namenda)
What are cholinesterase inhibitors prescribed for? - 🧠 ANSWER ✔✔- To
treat symptoms related to memory, thinking, language, judgment, and other
processes
- Helps delay or slow the worsening of symptoms
What does cholinesterase inhibitors do? - 🧠 ANSWER ✔✔- Prevent the
breakdown of acetylcholine, a chemical messenger that is important for
learning and memory
- Supports communication among nerve cells by keeping the acetylcholine
high
What are some commonly prescribed cholinesterase inhibitors? - 🧠
ANSWER ✔✔- Donepezil (aricept)
- Galantamine (razadyne)
- Rivastigmine (exeleon)
Which cholinesterase inhibitor can be used for all stages of Alzheimer's? -
🧠 ANSWER ✔✔- Donepezil (aricept)
,Which cholinesterase inhibitor can be used for mild-to-moderate stages of
Alzheimer's? - 🧠 ANSWER ✔✔- Galantamine (razadyne)
- Rivastigmine (exeleon)
Which cholinesterase inhibitor can be used for mild-to-moderate
Alzheimer's and Parkinson's? - 🧠 ANSWER ✔✔- Rivastigmine (exeleon)
What medication combination is used to treat moderate-to-severe
Alzheimer's? - 🧠 ANSWER ✔✔- Memantine (namenda) and donepezil
(aricept)
What is memantine (namenda) used for? - 🧠 ANSWER ✔✔- Prescribed to
improve memory, attention, reason, language, and the ability to perform
simple tasks
- Can be used alone or with other Alzheimer's disease treatments
How does memantine (namenda) work? - 🧠 ANSWER ✔✔- Regulates the
activity of glutamate, a chemical involved in information processing,
storage, and retrieval
- Improves mental functioning and ability to perform daily activities for some
people
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, What is the difference in MOA between cholinesterase inhibitors and
memantine (namenda)? - 🧠 ANSWER ✔✔- Cholinesterase inhibitors
prevent the breakdown of acetylcholine, whereas memantine (namenda)
regulates the activity of glutamate
What is ataxia? - 🧠 ANSWER ✔✔- Also known as cerebellum attacks
- Degenerative disease of the nervous system
- Many symptoms mimic those of being drunk (i.e. slurred speech,
stumbling, falling, and incoordination)
What causes the symptoms of ataxia? - 🧠 ANSWER ✔✔- The damage
caused to the cerebellum, the part of the brain that is responsible for
coordinating movements
- Can also be caused by damage to part of the spinal cord and nerves
What is the treatment for ataxia? - 🧠 ANSWER ✔✔- No treatment
- In some cases, treating the underlying causes (i.e. stopping medications
that cause ataxia)
- In other cases, it is a result from chicken pox or other viral infections
(likely to resolve on its own)