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NCLEX Prep – 200+ Practice Questions – GI, Pain, Renal, CNS, and Musculoskeletal Systems – Verified Expert Review

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This comprehensive 2025/2026 NCLEX preparation resource features over 200 expert-verified multiple-choice questions with detailed rationales covering five major nursing system domains: gastrointestinal (GI), pain and analgesia, renal/urological, central nervous system (CNS), and musculoskeletal disorders. Designed to strengthen clinical judgment and pharmacological knowledge, the document includes questions on common and critical conditions such as GERD, H. pylori, IBS, urinary tract infections, spasticity, epilepsy, schizophrenia, diuretic therapy, antidepressants, anxiolytics, and antipsychotics. The material also covers medication effects, side effects, interactions (e.g., NSAIDs, benzodiazepines, laxatives, muscle relaxants, CNS stimulants), patient safety considerations (such as fall risks and renal dosing), and nursing responsibilities including patient education, prioritization, and assessment. It provides test-style questions simulating NCLEX-RN and NCLEX-PN formats with rationales that promote deeper understanding of clinical scenarios. Relevant for: RN and LPN students preparing for the NCLEX-RN/PN exams Nursing students in pharmacology, med-surg, psych, or pathophysiology courses Internationally educated nurses seeking U.S. licensure Nurse educators needing verified practice question banks for clinical teaching Keywords: NCLEX 2025, GI pharmacology, urinary tract infection, diuretics, CNS drugs, schizophrenia, depression meds, antipsychotics, pain management, muscle relaxants, tizanidine, baclofen, stool softeners, serotonin antagonists, antidiarrheals, benzodiazepines, renal failure, electrolyte imbalance, drug interactions, drug safety, nursing exam practice

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GI, Pain, Renal, Musculoskeletal, and
CNS PrepU 2025 Expert Verified | Ace
the Test



What adverse effect could be related to a fall experienced by an older client

prescribed amitriptyline? - 🧠ANSWER ✔✔Orthostatic Hypotension




Explanation: Orthostatic hypotension, a common cause for falls, is an

adverse effect related to tricyclic antidepressants like amitriptyline. Urinary

retention (not frequency) is an adverse effect of amitriptyline but is not

related to the falls. Visual disturbances are not a common adverse effect.

A group of nursing students are reviewing information about CNS

stimulants. The students demonstrate understanding of the information

,when they identify which drug as being used to treat obesity? - 🧠ANSWER

✔✔Phentermine




Explanation: This drug is a CNS stimulant used to treat obesity. This CNS

stimulant is used to treat attention-deficit hyperactivity disorder. Modafinil is

a CNS stimulant used to treat narcolepsy. Methylphenidate is a CNS

stimulant used to treat attention-deficit hyperactivity disorder.

A nurse is planning teaching with a client who has had an anti-anxiety

medication prescribed. A priority action for would be to: - 🧠ANSWER ✔✔try

to identify and avoid factors that cause nervousness or insomnia.




Explanation: The nurse should try to help the client identify and avoid

factors that cause nervousness or insomnia, such as caffeine-containing

beverages and stimulant drugs. This may prevent or decrease the severity

of nervousness or insomnia so sedative-type drugs are not needed. The

nurse would not tell the client to take their anti-anxiety medications just

prior to going to bed or within 30 minutes of going to bed. The nurse would

not teach the client to avoid factors that make the nurse go to sleep.

,The nurse is working in post-op and the client has just come out of surgery.

The nurse notes that the clients respiratory rate is 4 breaths per minute.

The nurse has a standing order to give doxapram 0.5 mg/kg IV for

respiratory depression. What should the nurse do next? - 🧠ANSWER

✔✔Draw up the medication, have it checked by a second provider, have

suction close by, and give the medication.




Explanation: Doxapram is given for postanesthesia respiratory depression.

All medications should be double-checked by a second provider prior to

administration. Clients often vomit after being given doxapram so suction

should be close by. Narcan is not recommended because the client would

be in severe pain if the narcotic was counteracted by the Narcan.

Continually shaking and talking loudly to the client may stimulate the client

for that moment, but will not help continual respiratory depression.

A child was diagnosed with attention-deficit hyperactivity disorder and

methylphenidate was prescribed for treatment to be taken once a day in a

sustained release form. On future visits what is a priority nursing

assessment for this child? - 🧠ANSWER ✔✔Weight and Height




3
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, Explanation: The nurse needs to carefully track this child's weight and

height because the drug can cause weight loss, anorexia, and nausea that

could result in slowed or absent growth. There would be no need to monitor

breath sounds, respiratory rate, urine output, and kidney function. Although

arrhythmias may occur as an adverse effect necessitating an ECG, there is

no need to perform echocardiograms.

The home health nurse is gathering a client's medication prior to going to

see the physician. The nurse cannot find the bottle for the methylphenidate,

Daytrana. What would be the reason for this - 🧠ANSWER ✔✔This is a

transdermal patch medication




Explanation: Daytrana is a transdermal patch, which delivers the

medication slowly through the skin. Nurses do not normally misplace

medications. Medications are kept in specific places with many safeguards

in place for proper administration. Daytrana is not given IM or IV.

A nurse is reviewing information about anxiolytics. Which anxiolytics would

the nurse identify as the safest to use in older adult clients? - 🧠ANSWER

✔✔Buspirone

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