CHARPTER 11 DRUG THERAPY IN
GERIATRIC PATIENTS 2025//2026
WITH QUESTIONS AND ANSWERS
100% VERIFIED
Factors that underlie drug-drug interactions and adverse drug interactions among geriatric patients -
correct answer <<<✨✨✨1. altered pharmacokinetics
2. multiple and severe illnesses
3. multi-drug therapy
4.poor adherence
Physiologic changes that affect pharmacokinetics in elderly: Absorption - correct answer
<<<✨✨✨1). -rate of absorption is decreased due to delayed gastric emptying and reduced
splanchnic blood flow
2). -percentage of absorption does not change with age
3). -gastric acidity is reduced and may alter absorption of certain drugs
Physiologic changes that affect pharmacokinetics in elderly: Distribution - correct answer
<<<✨✨✨1). -Increased body fat: provides a storage depot for lipid soluble drugs which decreases
drug plasma levels causing reduction in response
2). -Decreased percent lean body mass: water soluble drugs become distributed in a smaller volume
than young adults and drug concentration is increased causing more intense effects
3). -Decreased total body water
3). -Reduced concentration of serum albumin: protein binding of drug decreases increasing the levels of
free drug to rise which can cause increase intensity of drug effects
Physiologic changes that affect pharmacokinetics in elderly: Metabolism - correct answer <<<✨✨✨-
rates of drug metabolism decline with age due to reduced hepatic blood flow,reduced live mass, and
decreased activity of some hepatic enzymes
-reduced liver function may prolong drug effects
Physiologic changes that affect pharmacokinetics in elderly: Excretion - correct answer <<<✨✨✨-
decreased renal function results in decreased renal blood flow, glomerular filtration rate, active tubular
secretion, and number of nephrons
GERIATRIC PATIENTS 2025//2026
WITH QUESTIONS AND ANSWERS
100% VERIFIED
Factors that underlie drug-drug interactions and adverse drug interactions among geriatric patients -
correct answer <<<✨✨✨1. altered pharmacokinetics
2. multiple and severe illnesses
3. multi-drug therapy
4.poor adherence
Physiologic changes that affect pharmacokinetics in elderly: Absorption - correct answer
<<<✨✨✨1). -rate of absorption is decreased due to delayed gastric emptying and reduced
splanchnic blood flow
2). -percentage of absorption does not change with age
3). -gastric acidity is reduced and may alter absorption of certain drugs
Physiologic changes that affect pharmacokinetics in elderly: Distribution - correct answer
<<<✨✨✨1). -Increased body fat: provides a storage depot for lipid soluble drugs which decreases
drug plasma levels causing reduction in response
2). -Decreased percent lean body mass: water soluble drugs become distributed in a smaller volume
than young adults and drug concentration is increased causing more intense effects
3). -Decreased total body water
3). -Reduced concentration of serum albumin: protein binding of drug decreases increasing the levels of
free drug to rise which can cause increase intensity of drug effects
Physiologic changes that affect pharmacokinetics in elderly: Metabolism - correct answer <<<✨✨✨-
rates of drug metabolism decline with age due to reduced hepatic blood flow,reduced live mass, and
decreased activity of some hepatic enzymes
-reduced liver function may prolong drug effects
Physiologic changes that affect pharmacokinetics in elderly: Excretion - correct answer <<<✨✨✨-
decreased renal function results in decreased renal blood flow, glomerular filtration rate, active tubular
secretion, and number of nephrons
