BHS 316 Exam 3 Questions and
Answers 100% PASS
Central Tolerance - CORRECT ANSWER-The 1st level of protection against
autoimmunity comes from the selection process in the development of both B and
T lymphocytes
Negative Selection - CORRECT ANSWER-Fate of immature B-cells in the bone
marrow
Dendritic cells + Medullary thymic epithelial cells (MTEC) - CORRECT
ANSWER-Mediates negative selection of T-cells of thymus, immature T-cells that
bind self-peptide are deleted
Autoreactive B-cells - CORRECT ANSWER-Will not receive T-cell help and
usually die by anergy or neglect due to competition
MHC Alleles - CORRECT ANSWER-Often associated with specific autoimmune
diseases; specific alleles may present certain self peptides better or may not work
well during negative selection in the thymus
T-regulatory cells - CORRECT ANSWER-1. Important for preventing
autoimmunity. Part of peripheral tolerance.
, 2. Important for controlling tolerance to food antigens, environmental antigens,
and limiting inflammatory responses These cells turn off other T-cells by either
secreting anti-inflammatory cytokines like IL-10 or TGF-Or by direct cell-cell
contact by several mechanisms that turns off APCs or T-cells.
3. T- regulatory cells act in an antigen specific manner generally.
Peripheral Tolerance - CORRECT ANSWER-2nd level of protection against
autoimmunity.
1. Deletion
2. Anergy
3. Ignorance
Immunologically privileged tissues - CORRECT ANSWER-1. Immune ignorance-
lack of negative selection due to low tissue specific protein expression outside of
privileged tissue.
2. Tissue normally secretes anti-inflammatory or suppressive cytokines like TGFb
3. Tissue has physical barriers that don't allow lymphocytes to readily enter unless
there is damage. Example: blood-brain barrier.
COPYRIGHT ©️ 2025 ALL RIGHTS RESERVED
Answers 100% PASS
Central Tolerance - CORRECT ANSWER-The 1st level of protection against
autoimmunity comes from the selection process in the development of both B and
T lymphocytes
Negative Selection - CORRECT ANSWER-Fate of immature B-cells in the bone
marrow
Dendritic cells + Medullary thymic epithelial cells (MTEC) - CORRECT
ANSWER-Mediates negative selection of T-cells of thymus, immature T-cells that
bind self-peptide are deleted
Autoreactive B-cells - CORRECT ANSWER-Will not receive T-cell help and
usually die by anergy or neglect due to competition
MHC Alleles - CORRECT ANSWER-Often associated with specific autoimmune
diseases; specific alleles may present certain self peptides better or may not work
well during negative selection in the thymus
T-regulatory cells - CORRECT ANSWER-1. Important for preventing
autoimmunity. Part of peripheral tolerance.
, 2. Important for controlling tolerance to food antigens, environmental antigens,
and limiting inflammatory responses These cells turn off other T-cells by either
secreting anti-inflammatory cytokines like IL-10 or TGF-Or by direct cell-cell
contact by several mechanisms that turns off APCs or T-cells.
3. T- regulatory cells act in an antigen specific manner generally.
Peripheral Tolerance - CORRECT ANSWER-2nd level of protection against
autoimmunity.
1. Deletion
2. Anergy
3. Ignorance
Immunologically privileged tissues - CORRECT ANSWER-1. Immune ignorance-
lack of negative selection due to low tissue specific protein expression outside of
privileged tissue.
2. Tissue normally secretes anti-inflammatory or suppressive cytokines like TGFb
3. Tissue has physical barriers that don't allow lymphocytes to readily enter unless
there is damage. Example: blood-brain barrier.
COPYRIGHT ©️ 2025 ALL RIGHTS RESERVED
