1 | Page
CPIA Exam Study Questions and
Answers Latest 2026
USDA-APHIS Animal Care Resource Policy #12
"Considerations of Alternatives to Painful/Distressful
Procedures" states that when a database search is the
primary means of considerations to alternatives of
painful and distressful procedures, that a narrative
should include all of the following except:
A. The name of the databases searched
B. The date the search was performed
C. The specific field of study
D. The search strategy (including scientifically relevant
terminology) used Ans: C. The specific field of study
Which of the following should be considered a significant
change to an animal use proposal?
A. change in departmental affiliation of the principal
investigator
B. change in start date of study
C. change in anesthetic agent
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D. change in fluid administration Ans: C. change in
anesthetic agent
Which of the following entities are required to release
information per the Freedom of Information Act?
A. OLAW
B. AAALAC
C. IACUC
D. HSUS Ans: A. OLAW
Training and instruction of personnel must include
guidance in which of the following areas?
A. Effective writing of animal use proposals
B. Proper use of personal protective equipment
C. Appropriate communication with animal activist
groups
D. Research or testing methods that limit the use of
animals Ans: D. Research or testing methods that limit
the use of animals
Which of the following procedures may correctly be
applied to Designated Member Review?
A. The IACUC Chair appoints one member to do the
Designated Member Review.
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B. The designated member reviewer is authorized to
approve, require modifications, or disapprove the
proposal.
C. All members receive information about the proposal
and send their votes to the designated member reviewer
for tallying.
D. Designated member review may be utilized to review
proposals when there is insufficient time to notify the
full membership of the proposal details. Ans: A. The
IACUC Chair appoints one member to do the Designated
Member Review.
In which of the following circumstances may animal work
begin before receipt of IACUC approval?
A. It is a continuing study awaiting three year renewal
and for which the renewal protocol has been submitted
to the IACUC.
B. It is a small pilot study on non-AWAR species.
C. It is a teaching activity that uses students' personally
owned dogs and cats.
D. There are no circumstances in which animal work may
begin before IACUC approval. Ans: D. There are no
circumstances in which animal work may begin before
IACUC approval.
Which of the statements below about the responsibility
and authority of the Institutional Official (IO) is false?
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A. The IO must have authority to commit institutional
resources in support of the animal care and use program.
B. The IO must be the institution's Chief Executive Officer
or some appointed by him with authority to fund
resources.
C. The IO may reinstate an animal activity that was
previously suspended by the IACUC.
D. The IO may suspend an animal activity that was
previously approved by the IACUC. Ans: C. The IO may
reinstate an animal activity that was previously
suspended by the IACUC.
With regard to conducting official IACUC business, the
definition of a quorum is:
A. More than fifty percent (a majority) of voting
members.
B. Fifty percent of voting and non-voting members
combined.
C. More than fifty percent (a majority) of voting and non-
voting members combined.
D. Fifty percent of the voting members. Ans: A. More
than fifty percent (a majority) of voting members
The proper sequence for a designated member review by
the IACUC is:
© 2025 All rights reserved
CPIA Exam Study Questions and
Answers Latest 2026
USDA-APHIS Animal Care Resource Policy #12
"Considerations of Alternatives to Painful/Distressful
Procedures" states that when a database search is the
primary means of considerations to alternatives of
painful and distressful procedures, that a narrative
should include all of the following except:
A. The name of the databases searched
B. The date the search was performed
C. The specific field of study
D. The search strategy (including scientifically relevant
terminology) used Ans: C. The specific field of study
Which of the following should be considered a significant
change to an animal use proposal?
A. change in departmental affiliation of the principal
investigator
B. change in start date of study
C. change in anesthetic agent
© 2025 All rights reserved
, 2 | Page
D. change in fluid administration Ans: C. change in
anesthetic agent
Which of the following entities are required to release
information per the Freedom of Information Act?
A. OLAW
B. AAALAC
C. IACUC
D. HSUS Ans: A. OLAW
Training and instruction of personnel must include
guidance in which of the following areas?
A. Effective writing of animal use proposals
B. Proper use of personal protective equipment
C. Appropriate communication with animal activist
groups
D. Research or testing methods that limit the use of
animals Ans: D. Research or testing methods that limit
the use of animals
Which of the following procedures may correctly be
applied to Designated Member Review?
A. The IACUC Chair appoints one member to do the
Designated Member Review.
© 2025 All rights reserved
, 3 | Page
B. The designated member reviewer is authorized to
approve, require modifications, or disapprove the
proposal.
C. All members receive information about the proposal
and send their votes to the designated member reviewer
for tallying.
D. Designated member review may be utilized to review
proposals when there is insufficient time to notify the
full membership of the proposal details. Ans: A. The
IACUC Chair appoints one member to do the Designated
Member Review.
In which of the following circumstances may animal work
begin before receipt of IACUC approval?
A. It is a continuing study awaiting three year renewal
and for which the renewal protocol has been submitted
to the IACUC.
B. It is a small pilot study on non-AWAR species.
C. It is a teaching activity that uses students' personally
owned dogs and cats.
D. There are no circumstances in which animal work may
begin before IACUC approval. Ans: D. There are no
circumstances in which animal work may begin before
IACUC approval.
Which of the statements below about the responsibility
and authority of the Institutional Official (IO) is false?
© 2025 All rights reserved
, 4 | Page
A. The IO must have authority to commit institutional
resources in support of the animal care and use program.
B. The IO must be the institution's Chief Executive Officer
or some appointed by him with authority to fund
resources.
C. The IO may reinstate an animal activity that was
previously suspended by the IACUC.
D. The IO may suspend an animal activity that was
previously approved by the IACUC. Ans: C. The IO may
reinstate an animal activity that was previously
suspended by the IACUC.
With regard to conducting official IACUC business, the
definition of a quorum is:
A. More than fifty percent (a majority) of voting
members.
B. Fifty percent of voting and non-voting members
combined.
C. More than fifty percent (a majority) of voting and non-
voting members combined.
D. Fifty percent of the voting members. Ans: A. More
than fifty percent (a majority) of voting members
The proper sequence for a designated member review by
the IACUC is:
© 2025 All rights reserved
