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NURS 721- pharmacology 2 Exam 1- local anesthetics Study Guide Review A+ 1. *all LAs are weak ____*: bases 2. LA MOA: reversibly block voltage gated sodium channels. 3. LAs bind to voltage gated sodium channels best when they are in which position?: inactivated (open) 4. which portion of the LA molecule binds to the receptor?: the charged (ioni