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Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
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10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules zl zl 20
Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
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MULTIPLE CHOICE zl
1. The principal function of the immune system is:
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a. Defense against cancer zl zl
b. Repair of injured tissues zl zl zl
c. Defense against microbial infections zl zl zl
d. Prevention of inflammatory diseases zl zl zl
e. Protection against environmental toxins zl zl zl
ANS: C z l
The immune system has evolved in the setting of selective pressures imposed by microbial inf
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ections. Although immune responses to cancer may occur, the concept that “immunosurveilla
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nce” against cancer is a principal function of the immune system is controversial. Repair of in
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jured tissues may be a secondary consequence of the immune responses and inflammation. Al
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though the immune system has regulatory features that are needed to prevent excessive infla
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mmation, prevention of inflammatory diseases is not a primary function. The immune system
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can protect against microbial toxins, but it generally does not offer protection against toxins of
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nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successful va
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ccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C z l
In 1798, Edward Jenner reported the first intentional successful vaccination, which was again
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st smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpo
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x was reported to be eradicated worldwide by a vaccination program. Effective vaccines agai
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nst tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are wid
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ely used. There is no effective vaccine against Mycobacterium tuberculosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens zl zl zl zl zl zl
b. Self-nonself discrimination zl
c. Recognition of microbial structures by both cell-associated and soluble receptors zl zl zl zl zl zl zl zl zl
d. Protection against viral infections zl zl zl
e. Responses that have the same kinetics and magnitude on repeated exposure to the sa zl zl zl zl zl zl zl zl zl zl zl zl zl
me microbe zl
ANS: A z l
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes
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, which are the central cellular components of the adaptive immune system. Both the innate an
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d the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same microb
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e, the adaptive immune response becomes more rapid and of greater magnitude; this is the ma
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nifestation of memory. zl zl
4. Antibodies and T lymphocytes are the respective mediators of which two types of im zl zl zl zl zl zl zl zl zl zl zl zl zl
munity?
a. Innate and adaptive zl zl
b. Passive and active zl zl
c. Specific and nonspecific zl zl
d. Humoral and cell-mediated zl zl
e. Adult and neonatal zl zl
ANS: D z l
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes pr
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oduce antibodies, which are the recognition and effector molecules of humoral immune respon
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ses to extracellular pathogens. T cells recognize and promote eradication of intracellular patho
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gens in cell- zl zl
mediated immunity. Passive and active immunity both can be mediated by either B or T lympho
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cytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocytes par
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ticipate in adult adaptive immunity but are still developing in the neonatal period.
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5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes zl zl zl zl zl zl
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes zl zl zl zl
c. Memory T cells and effector T cells zl zl zl zl zl zl
d. Helper cells and antigen-presenting cells zl zl zl zl
e. Cytotoxic T lymphocytes and target cells zl zl zl zl zl
ANS: A z l
T cells can be classified into effector subsets that perform different effector functions. Most eff
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ector T cells are either helper T lymphocytes, which enhance the responses of other immune c
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ells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which direct
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ly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. zl zl zl zl zl zl zl zl zl zl zl zl zl zl
6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells zl zl
b. Dendritic cells zl
c. Cytolytic T lymphocytes zl zl
d. B lymphocytes zl
e. Helper T lymphocytes zl zl
ANS: D z l
Humoral immune responses are antibody- zl zl zl zl
mediated immune responses, and all antibodies are made by B lymphocytes and no other ce
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ll type.
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Cellular and Molecular Immunology
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Abul Abbas, Andrew Lichtman, and Shiv Pillai
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10th Edition
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,Table of Contents
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Chapter 01 Properties and Overview of Immune Responses
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Chapter 02 Cells and Tissues of the Immune System
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Chapter 03 Leukocyte Circulation and Migration Into Tissues
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Chapter 04 Innate Immunity
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Chapter 05 Antibodies and Antigens
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Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
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Histocompatibility Complex Molecules zl zl 20
Chapter 07 Immune Receptors and Signal Transduction
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Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
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Chapter 09 Activation of T Lymphocytes
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Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
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Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
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Chapter 12 B Cell Activation and Antibody Production
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Chapter 13 Effector Mechanisms of Humoral Immunity
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Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
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Chapter 15 Immunologic Tolerance and Autoimmunity
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Chapter 16 Immunity to Microbes
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Chapter 17 Transplantation Immunology
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Chapter 18 Tumor Immunology
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Chapter 19 Hypersensitivity Disorders
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Chapter 20 Allergy
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Chapter 21 Primary and Acquired Immunodeficiencies
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,Chapter 01: Properties and Overview of Immune Responses
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Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
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MULTIPLE CHOICE zl
1. The principal function of the immune system is:
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a. Defense against cancer zl zl
b. Repair of injured tissues zl zl zl
c. Defense against microbial infections zl zl zl
d. Prevention of inflammatory diseases zl zl zl
e. Protection against environmental toxins zl zl zl
ANS: C z l
The immune system has evolved in the setting of selective pressures imposed by microbial inf
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ections. Although immune responses to cancer may occur, the concept that “immunosurveilla
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nce” against cancer is a principal function of the immune system is controversial. Repair of in
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jured tissues may be a secondary consequence of the immune responses and inflammation. Al
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though the immune system has regulatory features that are needed to prevent excessive infla
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mmation, prevention of inflammatory diseases is not a primary function. The immune system
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can protect against microbial toxins, but it generally does not offer protection against toxins of
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nonbiologic origin.
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2. Which of the following infectious diseases was prevented by the first successful va
zl zl zl zl zl zl zl zl zl zl zl zl
ccination?
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C z l
In 1798, Edward Jenner reported the first intentional successful vaccination, which was again
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st smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980, smallpo
zl zl zl zl zl zl zl zl zl zl zl zl zl zl zl zl
x was reported to be eradicated worldwide by a vaccination program. Effective vaccines agai
zl zl zl zl zl zl zl zl zl zl zl zl zl
nst tetanus toxin, rubella virus, and poliovirus were developed in the 20th century and are wid
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ely used. There is no effective vaccine against Mycobacterium tuberculosis.
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3. Which of the following is a unique property of the adaptive immune system?
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a. Highly diverse repertoire of specificities for antigens zl zl zl zl zl zl
b. Self-nonself discrimination zl
c. Recognition of microbial structures by both cell-associated and soluble receptors zl zl zl zl zl zl zl zl zl
d. Protection against viral infections zl zl zl
e. Responses that have the same kinetics and magnitude on repeated exposure to the sa zl zl zl zl zl zl zl zl zl zl zl zl zl
me microbe zl
ANS: A z l
, Highly diverse repertoires of specificities for antigens are found only in T and B lymphocytes
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, which are the central cellular components of the adaptive immune system. Both the innate an
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d the adaptive immune systems use cell-
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associated and soluble receptors to recognize microbes, display some degree of self-
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nonself discrimination, and protect against viruses. On repeated exposure to the same microb
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e, the adaptive immune response becomes more rapid and of greater magnitude; this is the ma
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nifestation of memory. zl zl
4. Antibodies and T lymphocytes are the respective mediators of which two types of im zl zl zl zl zl zl zl zl zl zl zl zl zl
munity?
a. Innate and adaptive zl zl
b. Passive and active zl zl
c. Specific and nonspecific zl zl
d. Humoral and cell-mediated zl zl
e. Adult and neonatal zl zl
ANS: D z l
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocytes pr
zl zl zl zl zl zl zl zl zl zl zl zl zl
oduce antibodies, which are the recognition and effector molecules of humoral immune respon
zl zl zl zl zl zl zl zl zl zl zl zl
ses to extracellular pathogens. T cells recognize and promote eradication of intracellular patho
zl zl zl zl zl zl zl zl zl zl zl zl
gens in cell- zl zl
mediated immunity. Passive and active immunity both can be mediated by either B or T lympho
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cytes. Specific immunity is another term for adaptive immunity. Both B and T lymphocytes par
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ticipate in adult adaptive immunity but are still developing in the neonatal period.
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5. The two major functional classes of effector T lymphocytes are:
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a. Helper T lymphocytes and cytotoxic T lymphocytes zl zl zl zl zl zl
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes zl zl zl zl
c. Memory T cells and effector T cells zl zl zl zl zl zl
d. Helper cells and antigen-presenting cells zl zl zl zl
e. Cytotoxic T lymphocytes and target cells zl zl zl zl zl
ANS: A z l
T cells can be classified into effector subsets that perform different effector functions. Most eff
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ector T cells are either helper T lymphocytes, which enhance the responses of other immune c
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ells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes, which direct
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ly kill infected cells. Natural killer cells are not T lymphocytes.
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Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. zl zl zl zl zl zl zl zl zl zl zl zl zl zl
6. Which of the following cell types is required for all adaptive humoral immune responses?
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a. Natural killer cells zl zl
b. Dendritic cells zl
c. Cytolytic T lymphocytes zl zl
d. B lymphocytes zl
e. Helper T lymphocytes zl zl
ANS: D z l
Humoral immune responses are antibody- zl zl zl zl
mediated immune responses, and all antibodies are made by B lymphocytes and no other ce
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ll type.
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