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Asthma symptoms - 🧠 ANSWER ✔✔- *Intermittent* occurrence of cough,
chest tightness, breathlessness, and wheezing.
- Patients undergo asymptomatic periods between attacks
- Correlate with common precipitants: allergens, exercise, *URI*, stress,
NSAIDs, environmental irritants (pet dander, smoke inhalation).
Diagnosing asthma - 🧠 ANSWER ✔✔- FEV1/FVC <75%
- >10% increase in FEV1 after bronchodilator
- Histamine/methacholine challenge test decreased FEV1 >20%
Asthma meds - 🧠 ANSWER ✔✔- *SABAs* (albuterol)
, - *LABAs + corticosteroids* (Symbicort, Advair)
- *Anticholinergics* (Ipratropium/Atrovent)
- *Mast cell stabilizers* (Cromolyn)
- *Leukotriene modifiers* (Singulair)
- *Methylxanthines* (Theophylline)
- *Anti-IgE antibodies* (Xolair)
MOA or corticosteroids - 🧠 ANSWER ✔✔Inhibit cytokine-induced
production of pro-inflammatory proteins.
MOA of leukotrienes - 🧠 ANSWER ✔✔Block the activation of CysLT and
the subsequent inflammatory cascade that cause symptoms associated
with asthma & allergic rhinitis.
MOA of anti-IgE antibodies - 🧠 ANSWER ✔✔Inhibits IgE from binding to
mast cells and basophils, which causes less mediates to be released in
allergic response.
MOA of SABA/LABAs - 🧠 ANSWER ✔✔Bronchodilation
DOC for nocturnal asthma symptoms - 🧠 ANSWER ✔✔Theophylline
(Methylxanthine class)