NSG 6005 midterm study guide Questions and
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Terms in this set (202)
-Part of the cell that is exposed to the outside
environment
Receptors -Causes specific action in the cell when activated
-Lock and key mechanism
May interact with a cell or may not
ligand molecules that bind to a receptor
-a molecule that, by binding to a receptor site,
stimulates a response
Agonist
-Any chemical that reacts with the extracellular
receptor to cause a physiologic change in the cell
-Reacts with the receptor, but does not cause the
physiologic change in the cell
Antagonist -Reversal agent for drug overdoses
-Used to induce a biological response by blocking
one pathway ("beta blockers")
-Chemicals that cause degradation of other
chemicals, but are not affected by the reaction
enzymes
-Main ones to know are the cytochrome P450
enzymes
Inducers -rapid drug breakdown with rapid half-life
, -enzyme activity slows down the breakdown with
Inhibitor
longer half-life
Absorption
Distribution
ADME
Metabolism
Excretion
*Route of administration Major factor how much drug
is getting into the body
Absorption -Gastric contents- Ph levels, food dependent
inactivated
-Diseases- gastric bypass, liver disease
-IV is the most efficient directly into the bloodstream
100% bio
Route of Administration -PO a little bit of a lost due to medication not
probably being absorbed through the digestive
-Topical very low viability
*Body fat lipid-binding drugs
*Hydration status will med be diluted or concentrated
Distribution
within the blood
*Cardiovascular health
*the combination of chemical reactions through which
an organism builds up or breaks down materials
-Genetics (Normal/Rapid/Poor)
-Diseases liver
Metabolism
*Other drugs - how would each impact the
metabolism rate of a drug?
-Enzyme inducer rapid metabolism
-Inhibitor slows down the rate of metabolism
-Process by which metabolic wastes are eliminated
Excretion from the body via urine through the kidneys
-Diseases & Other drugs can alter excretion
*Amount of time for the drug concentration to reach
Half-life half the initial level
-Usually measured in hours
Answers
Save
Terms in this set (202)
-Part of the cell that is exposed to the outside
environment
Receptors -Causes specific action in the cell when activated
-Lock and key mechanism
May interact with a cell or may not
ligand molecules that bind to a receptor
-a molecule that, by binding to a receptor site,
stimulates a response
Agonist
-Any chemical that reacts with the extracellular
receptor to cause a physiologic change in the cell
-Reacts with the receptor, but does not cause the
physiologic change in the cell
Antagonist -Reversal agent for drug overdoses
-Used to induce a biological response by blocking
one pathway ("beta blockers")
-Chemicals that cause degradation of other
chemicals, but are not affected by the reaction
enzymes
-Main ones to know are the cytochrome P450
enzymes
Inducers -rapid drug breakdown with rapid half-life
, -enzyme activity slows down the breakdown with
Inhibitor
longer half-life
Absorption
Distribution
ADME
Metabolism
Excretion
*Route of administration Major factor how much drug
is getting into the body
Absorption -Gastric contents- Ph levels, food dependent
inactivated
-Diseases- gastric bypass, liver disease
-IV is the most efficient directly into the bloodstream
100% bio
Route of Administration -PO a little bit of a lost due to medication not
probably being absorbed through the digestive
-Topical very low viability
*Body fat lipid-binding drugs
*Hydration status will med be diluted or concentrated
Distribution
within the blood
*Cardiovascular health
*the combination of chemical reactions through which
an organism builds up or breaks down materials
-Genetics (Normal/Rapid/Poor)
-Diseases liver
Metabolism
*Other drugs - how would each impact the
metabolism rate of a drug?
-Enzyme inducer rapid metabolism
-Inhibitor slows down the rate of metabolism
-Process by which metabolic wastes are eliminated
Excretion from the body via urine through the kidneys
-Diseases & Other drugs can alter excretion
*Amount of time for the drug concentration to reach
Half-life half the initial level
-Usually measured in hours
