,
, Lung Biology and
Pathophysiology
The lungs are the organ for gas exchange between the body and the external environment.
Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma,
chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in
airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx
of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas
exchange. In addition to lung structural cells, immune cells including alveolar macrophages and
lymphocytes play critical roles in the maintenance of lung function. This book contributes to the
understanding homeostasis of lung cells in the physiological and pathological conditions critical to
the development of novel therapeutics.
KEY FEATURES
• Highlights the role the lungs play as an interface between the body and the environment.
• Describes the underlying mechanism of lung diseases.
• Emphasizes the ways nutrition contributes to lung health and the ways pollution adversely
affects lung function.
• Includes contributions from leading researchers.
Yutong Zhao is Professor of Physiology and Cell Biology at The Ohio State University. He received
his clinical medical degree from Dalian Medical University in China and PhD degree from Gifu
University School of Medicine in Japan. He was trained in biochemistry, molecular biology, and
active lipid signaling during his PhD student period. He joined a pulmonary postdoctoral training
program at Johns Hopkins University School of Medicine and received his first National Institutes
of Health R01 funding at the University of Chicago as a Research Assistant Professor. Dr. Zhao is
an expert in research fields of lung biology, bioactive lysophospholipid, and protein ubiquitination.
His research focuses on investigating the pathogenesis of lung diseases including acute respiratory
distress syndrome, pulmonary fibrosis, pulmonary arterial hypertension, asthma, lung cancer, and
COPD. The goal of Dr. Zhao’s laboratory research is to develop new therapeutic targets for treating
lung diseases. Dr. Zhao is active in academic professional services as a reviewer, associate editor,
and member of editorial boards of scientific journals and grant review study sections.
ALGr a wa n y
, Methods in Signal Transduction
Series Editors
Joseph Eichberg, Jr. and Michael X. Zhu
The overall theme of this series continues to be the presentation of the wealth of up to date research
methods applied to the many facets of signal transduction. Each volume is assembled by one or
more editors who are pre-eminent in their specialty. In turn, the guiding principle for editors is to
recruit chapter authors who will describe procedures and protocols with which they are intimately
familiar in a reader-friendly format. The intent is to assure that each volume will be of maximum
practical value to a broad audience, including students and researchers just entering an area, as well
as seasoned investigators.
Lipid-Mediated Signaling Transduction, Second Edition
Eric Murphy, Thad Rosenberger, and Mikhail Golovko
Calcium Entry Channels in Non-Excitable Cells
Juliusz Ashot Kozak and James W. Putney, Jr.
Autophagy and Signaling
Esther Wong
Signal Transduction and Smooth Muscle
Mohamed Trebak and Scott Earley
Polycystic Kidney Disease
Jinghua Hu and Yong Yu
New Techniques for Studying Biomembranes
Qiu-Xing Jiang
Ion and Molecule Transport in Lysosomes
Bruno Gasnier and Michael X. Zhu
Neuron Signaling in Metabolic Regulation
Qingchu Tong
Non-Classical Ion Channels in the Nervous System
Tian-Le Xu and Long-Ju Wu
Immune Cells, Infammation, and Cardiovascular Diseases
Shyam S. Bansal
Opsin-Free Optogenetics: Technology and Applications
Yubin Zhou and Kai Zhang
Lung Biology and Pathophysiology
Yutong Zhao
For more information about this series, please visit: www.crcpress.com/Methods-in-Signal-Transduction-
Series/book-series/CRCMETSIGTRA?page=&order=pubdate&size=12&view=list&status=publis
hed,forthcoming
, Lung Biology and
Pathophysiology
The lungs are the organ for gas exchange between the body and the external environment.
Dysfunction of upper airway epithelium and smooth muscle cells leads to pathogenesis of asthma,
chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other conditions, resulting in
airway inflammation and narrowing. Injury to alveolar epithelium and endothelium causes influx
of neutrophil and protein-rich fluid from circulation, resulting in edema and disruption of gas
exchange. In addition to lung structural cells, immune cells including alveolar macrophages and
lymphocytes play critical roles in the maintenance of lung function. This book contributes to the
understanding homeostasis of lung cells in the physiological and pathological conditions critical to
the development of novel therapeutics.
KEY FEATURES
• Highlights the role the lungs play as an interface between the body and the environment.
• Describes the underlying mechanism of lung diseases.
• Emphasizes the ways nutrition contributes to lung health and the ways pollution adversely
affects lung function.
• Includes contributions from leading researchers.
Yutong Zhao is Professor of Physiology and Cell Biology at The Ohio State University. He received
his clinical medical degree from Dalian Medical University in China and PhD degree from Gifu
University School of Medicine in Japan. He was trained in biochemistry, molecular biology, and
active lipid signaling during his PhD student period. He joined a pulmonary postdoctoral training
program at Johns Hopkins University School of Medicine and received his first National Institutes
of Health R01 funding at the University of Chicago as a Research Assistant Professor. Dr. Zhao is
an expert in research fields of lung biology, bioactive lysophospholipid, and protein ubiquitination.
His research focuses on investigating the pathogenesis of lung diseases including acute respiratory
distress syndrome, pulmonary fibrosis, pulmonary arterial hypertension, asthma, lung cancer, and
COPD. The goal of Dr. Zhao’s laboratory research is to develop new therapeutic targets for treating
lung diseases. Dr. Zhao is active in academic professional services as a reviewer, associate editor,
and member of editorial boards of scientific journals and grant review study sections.
ALGr a wa n y
, Methods in Signal Transduction
Series Editors
Joseph Eichberg, Jr. and Michael X. Zhu
The overall theme of this series continues to be the presentation of the wealth of up to date research
methods applied to the many facets of signal transduction. Each volume is assembled by one or
more editors who are pre-eminent in their specialty. In turn, the guiding principle for editors is to
recruit chapter authors who will describe procedures and protocols with which they are intimately
familiar in a reader-friendly format. The intent is to assure that each volume will be of maximum
practical value to a broad audience, including students and researchers just entering an area, as well
as seasoned investigators.
Lipid-Mediated Signaling Transduction, Second Edition
Eric Murphy, Thad Rosenberger, and Mikhail Golovko
Calcium Entry Channels in Non-Excitable Cells
Juliusz Ashot Kozak and James W. Putney, Jr.
Autophagy and Signaling
Esther Wong
Signal Transduction and Smooth Muscle
Mohamed Trebak and Scott Earley
Polycystic Kidney Disease
Jinghua Hu and Yong Yu
New Techniques for Studying Biomembranes
Qiu-Xing Jiang
Ion and Molecule Transport in Lysosomes
Bruno Gasnier and Michael X. Zhu
Neuron Signaling in Metabolic Regulation
Qingchu Tong
Non-Classical Ion Channels in the Nervous System
Tian-Le Xu and Long-Ju Wu
Immune Cells, Infammation, and Cardiovascular Diseases
Shyam S. Bansal
Opsin-Free Optogenetics: Technology and Applications
Yubin Zhou and Kai Zhang
Lung Biology and Pathophysiology
Yutong Zhao
For more information about this series, please visit: www.crcpress.com/Methods-in-Signal-Transduction-
Series/book-series/CRCMETSIGTRA?page=&order=pubdate&size=12&view=list&status=publis
hed,forthcoming
