IMMUNOLOGY KUBY - EXAM 2
QUESTIONS AND ANSWERS
If a B cell has a non-productive rearrangement at the first K light chain allele, what will
happen next? - Correct Answers -Rearrangement will begin at the second K light chain
allele
At which stage during T cell development does cell commitment to the T cell lineage
occur? - Correct Answers -DN
Which of the following is the correct order of T cell development? - Correct Answers -
HSC-CLP-DN-SP-Mature T cell
Deficiency in RAG-1 and/or RAG-2 can affect the proper development of which of the
following cell types, resulting in decreased numbers of circulating cells of those types? -
Correct Answers -Both A and B
B cell development has a checkpoint to determine VhDJh rearrangement has produced
a successful combination that can interact with a surrogate light chain. At what point of
B cell development does this checkpoint occur? - Correct Answers -Between pro-B and
pre-B
In people infected with human cytomegalovirus, class I MHC and B2-microglobulin are
produced, but very little mature class I MHC complexed with viral antigen is found at the
cell surface. Inhibition of which of the following molecules by human cytomegalovirus
may explain this phenomenon? - Correct Answers -TAP
The pre-BCR is made up of: - Correct Answers -A completed functional heavy chain
and a surrogate light chain
The spacer sequence of a recombination signal sequence (RSS) is composed of how
many base pairs - Correct Answers -12 or 23
Which of the following TCR gene regions possesses a "D" segment? - Correct Answers
-Both A and C
Transition from a pro-B cell to a pre-B cell requires interaction of the cell with: - Correct
Answers -IL-7
QUESTIONS AND ANSWERS
If a B cell has a non-productive rearrangement at the first K light chain allele, what will
happen next? - Correct Answers -Rearrangement will begin at the second K light chain
allele
At which stage during T cell development does cell commitment to the T cell lineage
occur? - Correct Answers -DN
Which of the following is the correct order of T cell development? - Correct Answers -
HSC-CLP-DN-SP-Mature T cell
Deficiency in RAG-1 and/or RAG-2 can affect the proper development of which of the
following cell types, resulting in decreased numbers of circulating cells of those types? -
Correct Answers -Both A and B
B cell development has a checkpoint to determine VhDJh rearrangement has produced
a successful combination that can interact with a surrogate light chain. At what point of
B cell development does this checkpoint occur? - Correct Answers -Between pro-B and
pre-B
In people infected with human cytomegalovirus, class I MHC and B2-microglobulin are
produced, but very little mature class I MHC complexed with viral antigen is found at the
cell surface. Inhibition of which of the following molecules by human cytomegalovirus
may explain this phenomenon? - Correct Answers -TAP
The pre-BCR is made up of: - Correct Answers -A completed functional heavy chain
and a surrogate light chain
The spacer sequence of a recombination signal sequence (RSS) is composed of how
many base pairs - Correct Answers -12 or 23
Which of the following TCR gene regions possesses a "D" segment? - Correct Answers
-Both A and C
Transition from a pro-B cell to a pre-B cell requires interaction of the cell with: - Correct
Answers -IL-7
