D027 Practice Test Questions with Correct Answers Latest Update 2025/2026
1. A 26-year-old female presents to urgent care with complaints of extreme fatigue, muscle
aches, abdominal pain, numbness and tingling in her extremities, and bloating. She explains that
she has been experiencing gastrointestinal upset after meals and has not had a bowel
movement for the past four days. She reports using over-the-counter, anti-diarrheal products
last week to combat diarrhea. She denies having any chronic diseases. The assessment
findings include a blood pressure of 108/71 mm Hg, pulse of 82 beats per minute, and
respirations of 20 breaths per minute. The abdomen is distended and firm. Bowel sounds are
present in all four quadrants. The patient has a steady gait, though verbally complains of feeling
weak and off balance upon ambulation. Following antibody testing, Celiac disease is
suspected.Which follow-up tissue test, the gold standard for this suspected diagnosis, should
be ordered?
aa. Endoscopy - Answers Colonoscopy with rectal biopsy
1. A 44-year-old woman has recently been diagnosed with advanced metastatic non-small-cell
lung cancer. Genetic testing is ordered to determine if the patient's tumor has any genomic
alterations and to guide treatment decisions. A few weeks later, the patient's test results come
back positive for a genetic mutation. The APN starts osimertinib (Tagrisso).Based on this
information, what types of genetic mutation does this patient have? Choose 2 answers.
a. ALK mutation
b. EGFR mutation
c. BRCA mutation
d. MET amplification mutation - Answers ALK mutation and EGFR mutation
1. A 20-year-old male meets with an advanced professional nurse (APN) to discuss symptoms
that have been slowly progressing over the past several years. He is mainly concerned because
he has been falling frequently. Since childhood, his gait has consisted of walking on his toes.
During middle school, he was able to participate in sports but was unable to participate in high
school sports due to difficulty with running and jumping. Lately, he has noticed it takes longer
and is more difficult to change positions from sitting to standing than it used to in the past. He
has also been waking up with muscle and joint stiffness. The APRN notes that his family history
is not significant for any chronic or genetic diseases.Which condition is likely to be the cause of
these symptoms?
a. Becker muscular dystrophy
b. Myotonic dystrophy
c. Facioscapulohumeral muscular dystrophy (FSHD)
, d. Limb-girdle muscular dystrophy - Answers Becker muscular dystrophy
1. A patient with systemic lupus erythematosus (SLE) is diagnosed with idiopathic
thrombocytopenic purpura (ITP).Which statement should the provider give the patient regarding
the pathophysiology of SLE and its relation to thrombocytopenia?
a. SLE disrupts immune homeostasis and promotes development of self-reactive antibodies.
b. SLE causes a cross-reaction of antibodies with normal platelet antigens.
c. SLE causes a defect in the number and function of regulatory B cells.
d. SLE increases megakaryocyte maturation. - Answers SLE disrupts immune homeostasis and
promotes development of self-reactive antibodies.
1. A female patient presents to an office to establish care. Her previous primary care provider
told her to follow up regarding an elevated ferritin level. She has no previous medical history and
is currently asymptomatic. She is concerned about the elevated ferritin and would like to know if
she should be worried.What should the provider do next for this patient?
a. Order a liver function test
b. Order a renal ultrasound
c. Refer her for a bone marrow biopsy
d. Order a thyroid panel - Answers Order a liver function test
1. A 75-year-old female presents to the emergency department with an irregular heart rate of
130.What can be ascertained about this patient's findings given the limited information?
a. She has a normal sinus rhythm and needs her heart rate controlled with metoprolol
(Lopressor).
b. She is diagnosed with atrial fibrillation and needs her heart rate controlled with metoprolol
(Lopressor).
c. She is diagnosed with ventricular tachycardia and needs her heart rhythm controlled with
metoprolol (Lopressor).
d. She is diagnosed with torsades de pointes and needs her heart rate controlled with
magnesium. - Answers She is diagnosed with atrial fibrillation and needs her heart rate
controlled with metoprolol (Lopressor).
1. A 75-year-old male presents with a history of transient ischemic attack, acute myocardial
infarction, angina, and atrial fibrillation. The patient's echocardiogram shows low cardiac output
and loss of contractility.Which condition from this patient's medical history is contributing to the
1. A 26-year-old female presents to urgent care with complaints of extreme fatigue, muscle
aches, abdominal pain, numbness and tingling in her extremities, and bloating. She explains that
she has been experiencing gastrointestinal upset after meals and has not had a bowel
movement for the past four days. She reports using over-the-counter, anti-diarrheal products
last week to combat diarrhea. She denies having any chronic diseases. The assessment
findings include a blood pressure of 108/71 mm Hg, pulse of 82 beats per minute, and
respirations of 20 breaths per minute. The abdomen is distended and firm. Bowel sounds are
present in all four quadrants. The patient has a steady gait, though verbally complains of feeling
weak and off balance upon ambulation. Following antibody testing, Celiac disease is
suspected.Which follow-up tissue test, the gold standard for this suspected diagnosis, should
be ordered?
aa. Endoscopy - Answers Colonoscopy with rectal biopsy
1. A 44-year-old woman has recently been diagnosed with advanced metastatic non-small-cell
lung cancer. Genetic testing is ordered to determine if the patient's tumor has any genomic
alterations and to guide treatment decisions. A few weeks later, the patient's test results come
back positive for a genetic mutation. The APN starts osimertinib (Tagrisso).Based on this
information, what types of genetic mutation does this patient have? Choose 2 answers.
a. ALK mutation
b. EGFR mutation
c. BRCA mutation
d. MET amplification mutation - Answers ALK mutation and EGFR mutation
1. A 20-year-old male meets with an advanced professional nurse (APN) to discuss symptoms
that have been slowly progressing over the past several years. He is mainly concerned because
he has been falling frequently. Since childhood, his gait has consisted of walking on his toes.
During middle school, he was able to participate in sports but was unable to participate in high
school sports due to difficulty with running and jumping. Lately, he has noticed it takes longer
and is more difficult to change positions from sitting to standing than it used to in the past. He
has also been waking up with muscle and joint stiffness. The APRN notes that his family history
is not significant for any chronic or genetic diseases.Which condition is likely to be the cause of
these symptoms?
a. Becker muscular dystrophy
b. Myotonic dystrophy
c. Facioscapulohumeral muscular dystrophy (FSHD)
, d. Limb-girdle muscular dystrophy - Answers Becker muscular dystrophy
1. A patient with systemic lupus erythematosus (SLE) is diagnosed with idiopathic
thrombocytopenic purpura (ITP).Which statement should the provider give the patient regarding
the pathophysiology of SLE and its relation to thrombocytopenia?
a. SLE disrupts immune homeostasis and promotes development of self-reactive antibodies.
b. SLE causes a cross-reaction of antibodies with normal platelet antigens.
c. SLE causes a defect in the number and function of regulatory B cells.
d. SLE increases megakaryocyte maturation. - Answers SLE disrupts immune homeostasis and
promotes development of self-reactive antibodies.
1. A female patient presents to an office to establish care. Her previous primary care provider
told her to follow up regarding an elevated ferritin level. She has no previous medical history and
is currently asymptomatic. She is concerned about the elevated ferritin and would like to know if
she should be worried.What should the provider do next for this patient?
a. Order a liver function test
b. Order a renal ultrasound
c. Refer her for a bone marrow biopsy
d. Order a thyroid panel - Answers Order a liver function test
1. A 75-year-old female presents to the emergency department with an irregular heart rate of
130.What can be ascertained about this patient's findings given the limited information?
a. She has a normal sinus rhythm and needs her heart rate controlled with metoprolol
(Lopressor).
b. She is diagnosed with atrial fibrillation and needs her heart rate controlled with metoprolol
(Lopressor).
c. She is diagnosed with ventricular tachycardia and needs her heart rhythm controlled with
metoprolol (Lopressor).
d. She is diagnosed with torsades de pointes and needs her heart rate controlled with
magnesium. - Answers She is diagnosed with atrial fibrillation and needs her heart rate
controlled with metoprolol (Lopressor).
1. A 75-year-old male presents with a history of transient ischemic attack, acute myocardial
infarction, angina, and atrial fibrillation. The patient's echocardiogram shows low cardiac output
and loss of contractility.Which condition from this patient's medical history is contributing to the
