WILKES NSG 552 PSYCHOPHARMACOLOGY
EXAM 2 2026 COMPREHENSIVE EXAM
◉ Dopamine Pathways. Answer: - mesolimbic (positive sx)
- mesocortical (negative sx)
- nigrostriatal (EPS)
- tuberoinfundibular (prolactin)
◉ Metabolic Syndrome. Answer: cluster of conditions that incerase
risk for T2DM and cardiovascular disease (obesity, HTN, high
triglycerides, low HDL, insulin resistance)
-increased risk for metabolic syndrome found with some
antipsychotic medications, primarily SGA
◉ High Potency vs Low Potency. Answer: High potency: higher risk
for EPS/hyperprolactinemia. Effective at lower doses. Haldol,
risperdal, prolixin, olanzapine
Low potency: more sedating with more anticholinergic symptoms.
Thorazine, seroquel, clozaril, geodon
◉ Neuroleptic malignant syndrome (NMS). Answer: - Life
threatening
,- occur with use of dopamine receptor antagonists or when
dopaminergic medidcation are suddenly withdrawn
- sx usually begin within 2 wks of starting a new med or changing
dose.
- Characterized by fever, AMS, muscle rigidity, autonomic dysfuncton
- Dantrolene sodium is FDA approved to treat. Muscle relaxant that
reduces hyperthermia/muscle stiffness
◉ QTC interval. Answer: -measurement of the left ventricle's
repolarization efficiency on ECG.
- usually 350-450 (men), 360-460 (women)
-associated with life-threatening cardiac arrhythmias
-antipsychotic and antidepressant drugs can prolong QT intervals,
some more than others
◉ The study of the use of psychotropic medications in the treatment
of psychiatric disorders:. Answer: Psychopharmacology
◉ The study of what the body does to drugs:. Answer:
Pharmacokinetics
◉ The study of what drugs do to the body:. Answer:
Pharmacodynamics
, ◉ Involves the absorption, distribution, metabolism and excretion of
meds:. Answer: Pharmacokinetics
◉ Increase serum levels of other drugs that are substrates of that
enzyme:. Answer: CYP450 inhibtor
◉ Decrease serum levels of other drugs that are substrates of that
enzyme:. Answer: CYP inducer
◉ Part of the brain that regulates powerful emotions such as fear,
rage, sexual desires:. Answer: amygdala
◉ The relay station for sensory information:. Answer: thalamus
◉ Essential for maintaining homeostasis, controls basic needs such
as sleep-wake cycles:. Answer: hypothalamus
◉ This lobe is involved in executive functioning, high order planning,
speech adn motiviation:. Answer: frontal lobe
◉ Derived from Trytophan and made in the Ralphe Nuclei:. Answer:
serotonin
EXAM 2 2026 COMPREHENSIVE EXAM
◉ Dopamine Pathways. Answer: - mesolimbic (positive sx)
- mesocortical (negative sx)
- nigrostriatal (EPS)
- tuberoinfundibular (prolactin)
◉ Metabolic Syndrome. Answer: cluster of conditions that incerase
risk for T2DM and cardiovascular disease (obesity, HTN, high
triglycerides, low HDL, insulin resistance)
-increased risk for metabolic syndrome found with some
antipsychotic medications, primarily SGA
◉ High Potency vs Low Potency. Answer: High potency: higher risk
for EPS/hyperprolactinemia. Effective at lower doses. Haldol,
risperdal, prolixin, olanzapine
Low potency: more sedating with more anticholinergic symptoms.
Thorazine, seroquel, clozaril, geodon
◉ Neuroleptic malignant syndrome (NMS). Answer: - Life
threatening
,- occur with use of dopamine receptor antagonists or when
dopaminergic medidcation are suddenly withdrawn
- sx usually begin within 2 wks of starting a new med or changing
dose.
- Characterized by fever, AMS, muscle rigidity, autonomic dysfuncton
- Dantrolene sodium is FDA approved to treat. Muscle relaxant that
reduces hyperthermia/muscle stiffness
◉ QTC interval. Answer: -measurement of the left ventricle's
repolarization efficiency on ECG.
- usually 350-450 (men), 360-460 (women)
-associated with life-threatening cardiac arrhythmias
-antipsychotic and antidepressant drugs can prolong QT intervals,
some more than others
◉ The study of the use of psychotropic medications in the treatment
of psychiatric disorders:. Answer: Psychopharmacology
◉ The study of what the body does to drugs:. Answer:
Pharmacokinetics
◉ The study of what drugs do to the body:. Answer:
Pharmacodynamics
, ◉ Involves the absorption, distribution, metabolism and excretion of
meds:. Answer: Pharmacokinetics
◉ Increase serum levels of other drugs that are substrates of that
enzyme:. Answer: CYP450 inhibtor
◉ Decrease serum levels of other drugs that are substrates of that
enzyme:. Answer: CYP inducer
◉ Part of the brain that regulates powerful emotions such as fear,
rage, sexual desires:. Answer: amygdala
◉ The relay station for sensory information:. Answer: thalamus
◉ Essential for maintaining homeostasis, controls basic needs such
as sleep-wake cycles:. Answer: hypothalamus
◉ This lobe is involved in executive functioning, high order planning,
speech adn motiviation:. Answer: frontal lobe
◉ Derived from Trytophan and made in the Ralphe Nuclei:. Answer:
serotonin
