AANP Practice Questions – Latest 2025/2026
Exam Prep & Study Guide
A 65-year-old woman presents for a follow-up examination after a new patient visit. She
has not seen a healthcare provider for several years. She is a smoker and her
hypertension is now adequately controlled with medication. Her mother died at age 40
from a heart attack. The fasting lipid profile shows cholesterol = 240 mg/dL, HDL = 30,
and LDL = 200. In addition to starting Therapeutic Lifestyle Changes, the nurse
practitioner should start the patient on:
1.bile acid sequestrant.
2. a statin drug.
3. a cholesterol absorption inhibitor.
4. low-dose aspirin. - correct answerA statin drug
The most commonly prescribed medication for mild systemic lupus erythematosus
(SLE) is:
1. azathioprine (AZA).
2. belimumab (Benlysta).
3. ibuprofen (Advil).
4. cyclophosphamide (Cytoxan). - correct answeribuprofen (advil)
The most common sign of cervical cancer is:
1. postcoital bleeding.
2. strong odor from vaginal discharge.
3. itching in the vaginal area.
4. molluscum contagiosum. - correct answerpostcoital bleeding
The nurse practitioner prescribes amitriptyline (Elavil) for a patient with neuropathic pain
secondary to diabetes mellitus. On follow-up, the patient complains of urine retention
and dry mouth. The practitioner would:
1. discontinue amitriptyline and begin ibuprofen (Motrin).
2. refer to physical therapy.
3. start methocarbamol (Robaxin).
4. discontinue amitriptyline and begin gabapentin (Neurontin). - correct
answerdiscontinue amitriptyline and begin gabapentin (neurontin)
,A 17-year-old male with rheumatoid arthritis is being treated with an NSAID and
omeprazole (Prilosec). The patient complains of headache, abdominal pain, and gas.
These symptoms are most likely:
1. associated with the omeprazole.
2. related to the underlying condition.
3. the result of the NSAID.
4. caused by viral gastroenteritis. - correct answerassociated with the omeprazole
The medication of choice for the initial treatment of juvenile rheumatoid arthritis is:
1. acetaminophen.
2. prednisone.
3. aspirin.
4. ibuprofen. - correct answeribuprofen
A 12-year-old with sickle cell anemia has recently experienced a sickle cell crisis and
presents for a follow-up examination after a recent hospitalization. It is most important to
continue monitoring growth, development, and:
1. white blood cell levels.
2. fecal occult blood test.
3. hemoglobin levels.
4. urine dipsticks. - correct answerhemoglobin levels
A 90-year-old female is brought to the clinic by her neighbor. She states that everything
is fine, but the nurse practitioner notes that she has poor hygiene and bruises on her
trunk. The neighbor is concerned that the patient often has no money to buy food,
despite income from social security and a coal miner's pension. The nurse practitioner
suspects abuse. Which of the following is the nurse practitioner obligated to do next?
1. Report the case to the proper authorities.
2. Tell the neighbor to check on the woman daily and report back.
3. Document the data and report the information to risk management.
4. Call the patient's family and inquire about the concerns. - correct answerreport the
case to proper authorities
In most cases, the first manifestation of Alzheimer's disease is:
1. impaired judgment.
2. decrease in short-term memory.
3. disorientation in time and place.
4. decrease in long-term memory. - correct answerdecrease in short-term memory
The optimal treatment for latent tuberculosis is:
1. rifampin (Rifadin) for 5 months.
, 2. isoniazid (Nydrazid) for 9 months.
3. pyrazinamide for 6 months.
4. ethambutol for 6 months. - correct answerosioniazid (nydrazid) for 9 months
Unilateral spontaneous serous or serosanguineous discharge from a single duct of a
breast is most often caused by:
1. intraductal papilloma.
2. mucinous breast lesions.
3. Paget's disease.
4. ductal carcinoma in situ. - correct answerintraductal papilloma
A young child with asthma presents for follow-up evaluation. After numerous changes in
medications and doses, the parents report that the child continues to have difficulty with
coughing, especially during the night. Which of the following conditions would be the
most likely cause of the continued asthma symptoms?
1. Vocal cord dysfunction
2. Cystic fibrosis
3. Gastroesophageal reflux
4. Allergic rhinitis - correct answergastroesophageal reflux
A pregnant woman with known HIV infection can reduce the risk of perinatal
transmission through zidovudine (Retrovir) therapy. Based on current research, optimal
therapy is to start daily dosing:
1. post amniocentesis.
2. after 14 weeks of gestation.
3. if premature rupture of membranes occurs.
4. if maternal viral loads are greater than 10,000. - correct answerafter 14 weeks
gestation
T-wave inversion with a normal ST segment on a 12-lead EKG may represent:
1. acute coronary ischemia.
2. right ventricular hypertrophy.
3. atrial hypertrophy.
4. hyperkalemia. - correct answeracute coronary ischemia
The 16-year-old mother of a 2-month-old presents the infant, reporting that the child is
very irritable and does not feed well. During physical examination, the child's head
drops back and the child exhibits sudden flexing of the extremities. As the flexing stops,
the child cries uncontrollably. Funduscopic examination reveals retinal hemorrhages.
Which of the following diagnostic tests should be ordered?
1. Skull X-rays
Exam Prep & Study Guide
A 65-year-old woman presents for a follow-up examination after a new patient visit. She
has not seen a healthcare provider for several years. She is a smoker and her
hypertension is now adequately controlled with medication. Her mother died at age 40
from a heart attack. The fasting lipid profile shows cholesterol = 240 mg/dL, HDL = 30,
and LDL = 200. In addition to starting Therapeutic Lifestyle Changes, the nurse
practitioner should start the patient on:
1.bile acid sequestrant.
2. a statin drug.
3. a cholesterol absorption inhibitor.
4. low-dose aspirin. - correct answerA statin drug
The most commonly prescribed medication for mild systemic lupus erythematosus
(SLE) is:
1. azathioprine (AZA).
2. belimumab (Benlysta).
3. ibuprofen (Advil).
4. cyclophosphamide (Cytoxan). - correct answeribuprofen (advil)
The most common sign of cervical cancer is:
1. postcoital bleeding.
2. strong odor from vaginal discharge.
3. itching in the vaginal area.
4. molluscum contagiosum. - correct answerpostcoital bleeding
The nurse practitioner prescribes amitriptyline (Elavil) for a patient with neuropathic pain
secondary to diabetes mellitus. On follow-up, the patient complains of urine retention
and dry mouth. The practitioner would:
1. discontinue amitriptyline and begin ibuprofen (Motrin).
2. refer to physical therapy.
3. start methocarbamol (Robaxin).
4. discontinue amitriptyline and begin gabapentin (Neurontin). - correct
answerdiscontinue amitriptyline and begin gabapentin (neurontin)
,A 17-year-old male with rheumatoid arthritis is being treated with an NSAID and
omeprazole (Prilosec). The patient complains of headache, abdominal pain, and gas.
These symptoms are most likely:
1. associated with the omeprazole.
2. related to the underlying condition.
3. the result of the NSAID.
4. caused by viral gastroenteritis. - correct answerassociated with the omeprazole
The medication of choice for the initial treatment of juvenile rheumatoid arthritis is:
1. acetaminophen.
2. prednisone.
3. aspirin.
4. ibuprofen. - correct answeribuprofen
A 12-year-old with sickle cell anemia has recently experienced a sickle cell crisis and
presents for a follow-up examination after a recent hospitalization. It is most important to
continue monitoring growth, development, and:
1. white blood cell levels.
2. fecal occult blood test.
3. hemoglobin levels.
4. urine dipsticks. - correct answerhemoglobin levels
A 90-year-old female is brought to the clinic by her neighbor. She states that everything
is fine, but the nurse practitioner notes that she has poor hygiene and bruises on her
trunk. The neighbor is concerned that the patient often has no money to buy food,
despite income from social security and a coal miner's pension. The nurse practitioner
suspects abuse. Which of the following is the nurse practitioner obligated to do next?
1. Report the case to the proper authorities.
2. Tell the neighbor to check on the woman daily and report back.
3. Document the data and report the information to risk management.
4. Call the patient's family and inquire about the concerns. - correct answerreport the
case to proper authorities
In most cases, the first manifestation of Alzheimer's disease is:
1. impaired judgment.
2. decrease in short-term memory.
3. disorientation in time and place.
4. decrease in long-term memory. - correct answerdecrease in short-term memory
The optimal treatment for latent tuberculosis is:
1. rifampin (Rifadin) for 5 months.
, 2. isoniazid (Nydrazid) for 9 months.
3. pyrazinamide for 6 months.
4. ethambutol for 6 months. - correct answerosioniazid (nydrazid) for 9 months
Unilateral spontaneous serous or serosanguineous discharge from a single duct of a
breast is most often caused by:
1. intraductal papilloma.
2. mucinous breast lesions.
3. Paget's disease.
4. ductal carcinoma in situ. - correct answerintraductal papilloma
A young child with asthma presents for follow-up evaluation. After numerous changes in
medications and doses, the parents report that the child continues to have difficulty with
coughing, especially during the night. Which of the following conditions would be the
most likely cause of the continued asthma symptoms?
1. Vocal cord dysfunction
2. Cystic fibrosis
3. Gastroesophageal reflux
4. Allergic rhinitis - correct answergastroesophageal reflux
A pregnant woman with known HIV infection can reduce the risk of perinatal
transmission through zidovudine (Retrovir) therapy. Based on current research, optimal
therapy is to start daily dosing:
1. post amniocentesis.
2. after 14 weeks of gestation.
3. if premature rupture of membranes occurs.
4. if maternal viral loads are greater than 10,000. - correct answerafter 14 weeks
gestation
T-wave inversion with a normal ST segment on a 12-lead EKG may represent:
1. acute coronary ischemia.
2. right ventricular hypertrophy.
3. atrial hypertrophy.
4. hyperkalemia. - correct answeracute coronary ischemia
The 16-year-old mother of a 2-month-old presents the infant, reporting that the child is
very irritable and does not feed well. During physical examination, the child's head
drops back and the child exhibits sudden flexing of the extremities. As the flexing stops,
the child cries uncontrollably. Funduscopic examination reveals retinal hemorrhages.
Which of the following diagnostic tests should be ordered?
1. Skull X-rays
